FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term RNA endonuclease activity ID (Ontology) GO:0004521 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.[ ISBN:0198547684 ]
Also Known As "endoribonuclease activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      40
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 RNA endonuclease activity (all annotations which use CV term, excluding "NOT" statements)       5     40
     enables | RNA endonuclease activity       --      40
 NOT | enables | RNA endonuclease activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
nuclease activity
 |__endonuclease activity__________
 |__RNA nuclease activity__________|
catalytic activity, acting on RNA  |
 |__RNA nuclease activity__________|
                                   RNA endonuclease activity  67 rec.
                                    |__Enterobacter ribonuclease activity
                                    |__ribonuclease A activity
                                    |__ribonuclease MRP activity 2 rec.
                                    |__ribonuclease T1 activity
                                    |__ribonuclease T2 activity 1 rec.
                                    |__ribonuclease U2 activity
                                    |__RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
                                    |   |__ribonuclease F activity
                                    |   |__ribonuclease V activity
                                    |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism 22 rec.
                                    |   |__3'-tRNA processing endoribonuclease activity 1 rec.
                                    |   |__endoribonuclease activity, cleaving miRNA-paired mRNA 1 rec.
                                    |   |__endoribonuclease activity, cleaving siRNA-paired mRNA 1 rec.
                                    |   |__phosphodiesterase decapping endonuclease activity
                                    |   |__ribonuclease [poly-(U)-specific] activity
                                    |   |__ribonuclease E activity
                                    |   |__ribonuclease III activity 4 rec.
                                    |   |__ribonuclease IV activity
                                    |   |__ribonuclease IX activity
                                    |   |__ribonuclease M5 activity
                                    |   |__ribonuclease P activity 5 rec.
                                    |   |__ribonuclease P4 activity
                                    |   |__RNA lariat debranching enzyme activity 1 rec.
                                    |   |__RNA-(apurinic or apyrimidinic site) endonuclease activity
                                    |   |__RNA-DNA hybrid ribonuclease activity 6 rec.
                                    |__rRNA endonuclease activity
                                    |__tRNA-intron lyase activity 3 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a endonuclease activity
RNA nuclease activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "endonuclease G activity" RELATED
    "endoribonuclease activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced"
Reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs"
Reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA"
Reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA"
Reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol"
Reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA"
Reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA"
Reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA"
Reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand"
Reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA"
Reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"
Reactome:R-HSA-9708327 "ANG cleaves tRNA to yield tRNA halves"
Reactome:R-HSA-9708812 "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)"
Reactome:R-HSA-9948427 "ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide"