A postdoctoral position is available at the NIEHS/NIH to investigate double strand break repair and the formation of new telomeres in Drosophila. Two projects are ongoing. One is the characterization of a protein, MU2, involved in DNA repair. Mutations in the mutator gene, mu2, in Drosophila cause a high frequency of broken chromosomes that have lost a telomere and gained a new telomere do novo. We have used these broken chromosome ends to investigate telomere structure and are now pursuing the nature of the mutator, itself. Recent evidence suggests that mu2 is orthologous to human MDC1, a component of repair foci that form around broken chromosome ends to facilitate DNA repair and proper cell cycle control. We plan to investigate all aspects of mu2 biology, including the nature of repair foci, protein-protein interactions, cell specificity, and evolution. The second project is to investigate the nature of telomeres in Drosophila. These studies may examine chromatin structure at telomeres, especially as it may be regulated by RNAi mechanisms, and the regulation of transposition of LINE-like retrotransposons to chromosome ends,
Candidates should have a broad knowledge of molecular biology with an emphasis on protein biochemistry and/or chromatin structure. Knowledge of Drosophila genetics will also be advantageous. Applicants must have a Ph.D. or MD or equivalent and less than five years of postdoctoral experience.
TO APPLY: Send a cover letter, CV and three letters of recommendation to firstname.lastname@example.org.
Dr. James M. Mason
Laboratory of Molecular Genetics, MD D3-06
National Institute of Environmental Health Sciences
P.O. Box 12233
Research Triangle Park, NC 27709-2233
Phone: (919) 541-4483
Fax: (919) 541-7593
The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.