A Postdoc position (3 years) is available in the research group of Annette Schenck at the Department of Human Genetics at the Nijmegen Centre of Molecular Life Science (NCMLS) - Donders Institute for Brain, Cognition and Behaviour - Radboud University Nijmegen Medical Centre in Nijmegen, the Netherlands.
The Department of Human Genetics in Nijmegen is a world-leading place for research into genetic forms of brain disorders, where clinical research, disease gene identification and functional studies work hand in hand. Using disease genes as an entry point and Drosophila as a primary research tool, the group of Annette Schenck dissects gene function, molecular networks and mechanisms that underlie brain development and cognition and aims to translate this knowledge back to humans.
The project, funded through the European Union’s large-scale FP7 network GenCoDys (Genetic and Epigenetic Networks in Cognitive Dysfunction), aims to systematically elucidate the function of genes implicated human Mental Retardation Disorders. More than 300 genes are conserved in fly and can be characterised for their role in non-associative learning using RNAi and an innovative high-throughput semi-automated system to measure jump-reflex habituation (in collaboration with Dr. Z. Asztalos/Aktogen Ltd, Cambridge, consortium member). The lab, department and FP7 consortium offer great opportunities to follow up on the most interesting phenotypes and genes, e.g. by structural nervous system analyses, by dissection of associated signalling pathways or identification of transcriptional targets, and by the identification of genetic or chemical modifiers that alleviate learning or other defects. The goal of our large scale research is to identify novel molecular networks that provide conceptual advance in our understanding of brain development in health and disease. We also aim to significantly contribute to the development of novel diagnostic and therapeutic strategies for the large and still growing group of MR disorders.
GenCoDys partners of the Drosophila work package are A. Schenck (WP leader); K. Keleman/B.J. Dickson (Vienna); P. Tomancak (Dresden); Z. Asztalos/Aktogen Ltd (Cambridge); Network coordinator: H. van Bokhoven (Nijmegen).
• A PhD in a domain of Molecular Life Sciences
• Strong background in Drosophila genetics, and ideally in neurobiology, good knowledge in molecular and cell biology
• high affinity for fundamental research related to human disease
• Highly motivated, with excellent interpersonal and communication skills and with the strong wish to work interdisciplinary.
Enthusiastic, creative and interactive researchers that meet these demands are encouraged to apply or contact us for further information.
Selected Publications: (1) Anitei, M. et al. Nat Cell Biol, 2010, 12(4):330-40; (2) Zweier, C. et al. Am J Human Genetics, 2009; (3) Schenck, A. et al. Cell, 2008, 133: 486-497; (4) Qurashi, A. et al. Neural Development, 2007, 2: 18; (5) Kim et al. Nature, 2006, 442:814-7; (6) Schenck, A. et al. Dev Biol, 2004, 274 : 260-70; (7) Schenck, A. et al. Neuron, 2003, 38: 887-98.
Nijmegen: Nijmegen, located about 100 km from Amsterdam near the German border, is the Netherlands' oldest city. It offers historic sites and museums, borders beautiful forest countryside and polder landscapes and hosts one of the Netherland’s most successful universities with a particular emphasis on biomedical research and Neuroscience.
Send your application including a letter of motivation, CV and two letters of recommendation to Dr. Annette Schenck, E-mail: firstname.lastname@example.org. Only complete application documents will be considered. Please indicate “Flybase ad #010137" in the subject line of the e-mail.
Closing date is October, 1st 2010.