Postdoctoral Position Available: A fundamental question in many fields of biology is how the output of a signaling pathway is regulated. An NIH-funded postdoctoral/research associate position is available in the Wharton lab to study the molecular and cellular basis of BMP ligand and receptor dynamics that ultimately generate a gradient of signaling activity critical for the specification of different cell fates and growth during development. Our previous studies have highlighted the different behaviors of two BMP ligands, Dpp and Gbb, and two type I receptors, Tkv and Sax, in the generation of the pMad gradient required for Drosophila wing patterning and growth. We aim to understand the molecular basis of these differences with regard to signaling output and the spatial regulation of this output.
Priority will be given to highly motivated applicants that have demonstrated expertise in: Drosophila genetics, basic molecular biology and cell biology techniques, and/or biochemistry. Candidate must have a PhD in biology, genetics, biochemistry, or developmental biology with 3-5 years of research experience. Previous experience with Drosophila as a model system is preferred but not required.
Brown University is a stimulating academic environment with many opportunities for interdisciplinary interactions. Providence, RI is an affordable, culturally rich city close to the ocean, with easy access to Boston and NYC. Interested applicants should send their CV, including relevant research experience, and three references to Kristi_Wharton@brown.edu.
Bangi, E. and Wharton, K.A. (2006) Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning. Developmental Biology 295, 178-193.
Bangi, E. and Wharton, K. A. (2006). Dual function of the Drosophila ALK1/ALK2 orthologue, Saxophone, influences the BMP activity gradient critical for wing patterning. Development 133, 3295-3303.
Le, V.Q. and Wharton, K.A. (2012) Hyperactive BMP signaling induced by ALK2R206H requires type II receptor function in a Drosophila model for classic Fibrodysplasia Ossificans Progressiva. Developmental Dynamics 241, 200-214. PMID: 22174087
Akiyama, T., Marques, G. and Wharton, K. A. (2012). A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing. Science Signaling 5, ra28 (3 April 2012).