A post-doctoral position, funded for two years by the IFCPAR (Indo-French Center for Advanced Research) is available to study mechanisms of sex-determination in Drosophila (in parallel with studies in Bombyx to be performed in Hyderabad). The project will examine the splicing and expression-level targets of DOA protein kinase identified in recent RNA-Seq studies which require molecular validation and functional (i.e. genetic) investigation. Additional aspects of the project include validation of sex-specifically regulated transposons identified in the screen and their responsiveness to changes in loci affecting sex determination.
For some references see:
Rabinow, L. 2012 Encyclopedia of Cell Signaling, S. Choi, ed. (Springer). "The CLK/LAMMER kinases." p. 431-444.
Rabinow, L. & M.L. Samson. 2010 J. Genetics 89: 271-277. ”The role of the Drosophila LAMMER kinase DOA in somatic sex-determination. ”
Kpebe, A. & L. Rabinow; 2008a Genetics 179: 1973-1987. “Dissection of DOA kinase isoform functions in Drosophila.”
Kpebe, A. & L. Rabinow; 2008b Genesis 46: 132-143. “Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase.”
Du, C., E. McGuffin, B. Dauwalder, L. Rabinow* & W. Mattox: 1998 Molecular Cell 2: 741-750. "Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila.
The laboratory is located on the suburban campus of the University of Paris Sud (South), 26 km. southwest of Paris on the RER-B train line (about 45 minutes from the center of Paris). Health insurance is included with the stipend. Indian citizenship is required. Experience with Drosophila highly preferred and qPCR expertise a plus. Knowledge of French not required but helpful for living in the community. Further information upon request. Applicants should arrange to have three letters of recommendation and a complete CV sent to:
Centre de Neurosciences de Paris Sud
CNRS UMR 8195
Université Paris Sud XI
Bât. 442 bis
Phone: +33 1 69 15 74 65
fax: 77 26