A postdoctoral position is available to study virus-host interactions of arboviruses using Drosophila as a model insect with a particular focus on intrinsic innate immune mechanisms. We have performed genome-wide RNAi screens in Drosophila cells with four diverse viruses and identified a large number of genes and pathways involved in innate immune restriction. The successful candidate will conduct detailed mechanistic studies on innate immune factors to determine the mechanism-of-action in vivo in adult flies and complement these studies using mosquito and human cell lines. Candidates with expertise in Drosophila genetics of innate immunity is highly desirable. Novel training opportunities are provided in functional genomics, viral pathogenesis, viral immunity and virus-host interactions in a highly interactive environment. Project goals seek to dissect the biology of innate recognition of arboviruses that ultimately determine viral pathogenesis outcomes.
Candidates must have a Ph.D. in Drosophila genetics, molecular biology, cell biology, immunology, virology or related field and a solid publication record in peer-reviewed journals. Candidates eligible for NIH training grant positions are preferred.
To apply, please submit CV, statement of research interests and experience, and contact information for three references (including Ph.D. advisor and/or current supervisor) to: Dr. Sara Cherry (firstname.lastname@example.org).
Sara Cherry PhD
Department of Microbiology
Penn Genome Frontiers Institute
University of Pennsylvania School of Medicine
304K Lynch Laboratories
433 South University Avenue
Philadelphia, PA 19104-6018