Aberration Dmel\Df(3L)ri-XT1

General Information
Symbol	Dmel\Df(3L)ri-XT1	Species	D. melanogaster
Name		FlyBase ID	FBab0000008
Feature type	chromosomal_deletion
Also Known As	Df(3L)ri^XT1, Df(3L)riXT1

Computed Breakpoints include	77E2;[>78A4]
Deleted segment	77E2--78A4
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Correia et al., 2003)
Class of aberration (relative to progenitor)	chromosomal_deletion (Cook, 2002.5.15)
Breakpoints	77E2-77E4;78A2-78A4 (Cook, 2002.5.15)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << knrl << fng << bk2
Genetic mapping information
Comments
Comments on Cytology
	The 77E1-4 quadruplet is attenuated, but a distal portion is still present. The 78A5,6 doublet is present, but the 78A1,2 doublet is absent. (Cook, 2002.5.15) Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of kni (FBrf0045941) Left limit of break 2 from inclusion of fng (FBrf0076041)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Fer1HCH (BDGP Project Members, 1994-1999) fng (Correia et al., 2003, Irvine and Wieschaus, 1994) kni (Chen et al., 1998, Boube et al., 2001, Tearle and Nusslein-Volhard, 1987, Oro et al., 1989, Tremml and Bienz, 1989, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994, Ruden and Jaeckle, 1995) knrl (Chen et al., 1998, Boube et al., 2001, Oro et al., 1989, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994, Ruden and Jaeckle, 1995) l(3)D67 (Slack et al., 2006) l(3)G34 (Slack et al., 2006) Pka-R1 (Yoshida et al., 2004) Syx1A (BDGP Project Members, 1994-1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	siz (Chen et al., 2003)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Homozygous lethal. Lethal in combination with fng⁸⁰ and fng¹³ semi-viable in combination with fng^M69 (at 18^oC), fng⁵² and fng², with 5.0%, 3.3%, and 2.3% of animals surviving to adulthood. (Correia et al., 2003) In Df(3L)ri-XT1 mutant embryos, the developing small intestine and the rectum epithelia in the hindgut and the esophagus epithelium in the foregut start to lose integrity in mutants leading to a disconnection is seen of the hindgut and the midgut. Larger nuclei and larger cells are seen in the hindgut epithelial cells of mutant embryos. (Fuss et al., 2001)
NOT in combination with other aberrations	The Df(3L)ri-XT1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Mutant embryos have defects in the visceral branch of the tracheal system. Only five tracheal metameres develop, and the tracheal cells do not migrate. When partially rescued with kni^tRa, segmentation is restored, but dorsal and ventral branches have breaks in the dorsal trunk. Embryos usually lack the visceral branches and if present they are very rudimentary. (Boube et al., 2001) Tracheal metameres in remaining 5 abdominal segments of homozygotes show much more disrupted phenotype than kni⁸. Rudimentary tracheal metameres invaginate but lack primary branching and interconnections. When combined with kni^tRa, dorsal trunk formation is similar to wild type, though dorsal outgrowth fails and lateral trunk fusion is only partial. Visceral and ganglionic tracheal branches fail to reach the gut and nervous system. Lack of tracheal branch formation is caused by failure of cell migration. (Chen et al., 1998) Homozygous embryos display abdominal segmentation defect. One copy of Res^1r1 lacks the rescued abdominal segments. (Ruden and Jaeckle, 1995) Deletion of abdominal segments, severe head defect and absence of SNS. SNS defect can be rescued by expression of either the kni^tRa or knrl^kni.PR construct. Phenotypic rescue with the knrl transgene is dose dependent, three copies provides an almost normal head as strong as that observed with two copies of kni transgene. (Gonzalez-Gaitan et al., 1994) Mutant abdominal phenotype of Df(3L)ri-XT1 embryos can be rescued by P{kniSH} but only weak rescue of head defects. (Rothe et al., 1992)
Stocks ( 2 )
Bloomington	5878 Df(3L)ri-XT1, ru¹ st¹ e¹ ca¹/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹
Kyoto	108476 Df(3L)ri-XT1, ru¹ st¹ e¹ ca¹/TM3, Ser¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(3L)ri^-XT1 (Yoshida et al., 2004) Df(3L)ri^XT1 (Fusse and Hoch, 2002, Boube et al., 2001, Fuss et al., 2001, Boube et al., 2000, Chen et al., 1998, Rothe et al., 1994, Ruden and Jaeckle, 1995, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994) Df(3L)ri^xTi (Tremml and Bienz, 1989) Df(3L)riXT1 (Ribeiro et al., 2002, Boube et al., 2000, Irvine and Wieschaus, 1994, Thomas and van Meyel, 2007, Schittenhelm et al., 2009) Df(3L)ri-XT1 (Nakayama et al., 2011, Araujo et al., 2007, Munoz-Soriano et al., 2012) Df(3l)ri-XT1 (Slack et al., 2006) Df(3L)XT1 (Tearle and Nusslein-Volhard, 1987) DfriXT1 (Correia et al., 2003) fng^Df (Thomas and van Meyel, 2007) XT1 (Oro et al., 1989)
Name Synonym
Secondary FlyBase IDs

References ( 28 )

Generate a list of	All references relating to this aberration ( 28 )

List References by type	Research paper ( 22 ) Review ( 1 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Stock list ( 1 )
Recent research papers ( 2 )
	Munoz-Soriano et al., 2012, J. Mol. Neurosci. 48(1): 136--143 Septin 4, the Drosophila Ortholog of Human CDCrel-1, Accumulates in parkin Mutant Brains and is Functionally Related to the Nedd4 E3 Ubiquitin Ligase. [FBrf0219099] Nakayama et al., 2011, PLoS ONE 6(8): e22984 Drosophila carrying pex3 or pex16 mutations are models of zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. [FBrf0214614] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...