A Database of Drosophila Genes & Genomes

 

Aberration Dmel\Df(3L)ri-XT1

General Information
SymbolDmel\Df(3L)ri-XT1SpeciesD. melanogaster
NameFlyBase IDFBab0000008
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << knrl << fng << bk2
Sequence coordinates
Deleted segment77E2--78A4
Duplicated segment
Computed Breakpoints include 77E2;[>78A4]
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Correia et al., 2003)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Cook, 2002.5.15)
Breakpoints
77E2-77E4;78A2-78A4
(Cook, 2002.5.15)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of kni (FBrf0045941) Left limit of break 2 from inclusion of fng (FBrf0076041)
 
The 77E1-4 quadruplet is attenuated, but a distal portion is still present. The 78A5,6 doublet is present, but the 78A1,2 doublet is absent.
(Cook, 2002.5.15)
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
knrl
(Oro et al., 1989, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994, Ruden and Jaeckle, 1995, Chen et al., 1998, Boube et al., 2001)
fng
(Irvine and Wieschaus, 1994, Correia et al., 2003)
kni
(Tearle and Nusslein-Volhard, 1987, Oro et al., 1989, Tremml and Bienz, 1989, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994, Ruden and Jaeckle, 1995, Chen et al., 1998, Boube et al., 2001)
Syx1A
(BDGP Project Members, 1994-1999)
Fer1HCH
(BDGP Project Members, 1994-1999)
Pka-R1
(Yoshida et al., 2004)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
siz
(Chen et al., 2003)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
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hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Deletion of abdominal segments, severe head defect and absence of SNS. SNS defect can be rescued by expression of either the knitRa or knrlkni.PR construct. Phenotypic rescue with the knrl transgene is dose dependent, three copies provides an almost normal head as strong as that observed with two copies of kni transgene.
(Gonzalez-Gaitan et al., 1994)
Homozygous embryos display abdominal segmentation defect. One copy of Res1r1 lacks the rescued abdominal segments.
(Ruden and Jaeckle, 1995)
Mutant abdominal phenotype of Df(3L)ri-XT1 embryos can be rescued by P{kniSH} but only weak rescue of head defects.
(Rothe et al., 1992)
Mutant embryos have defects in the visceral branch of the tracheal system. Only five tracheal metameres develop, and the tracheal cells do not migrate. When partially rescued with knitRa, segmentation is restored, but dorsal and ventral branches have breaks in the dorsal trunk. Embryos usually lack the visceral branches and if present they are very rudimentary.
(Boube et al., 2001)
The Df(3L)ri-XT1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,wvar}2Lt insertion).
(Mason et al., 2004)
Tracheal metameres in remaining 5 abdominal segments of homozygotes show much more disrupted phenotype than kni8. Rudimentary tracheal metameres invaginate but lack primary branching and interconnections. When combined with knitRa, dorsal trunk formation is similar to wild type, though dorsal outgrowth fails and lateral trunk fusion is only partial. Visceral and ganglionic tracheal branches fail to reach the gut and nervous system. Lack of tracheal branch formation is caused by failure of cell migration.
(Chen et al., 1998)
hide Position Effect Variegation Data
  
hide Stocks ( 2 )
Kyoto
108476
Df(3L)ri-XT1, ru1 st1 e1 ca1/TM3, Ser1
Bloomington
5878
Df(3L)ri-XT1, ru1 st1 e1 ca1/TM3, P{Ubx-lacZ.w+}TM3, Sb1
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
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      hide Synonyms & Secondary IDs ( 9 )
      Reported As
      Symbol Synonym
      Df(3L)ri-XT1
      (Yoshida et al., 2004)
      Df(3L)riXT1
      (Fusse and Hoch, 2002, Boube et al., 2001, Fuss et al., 2001, Boube et al., 2000, Chen et al., 1998, Rothe et al., 1994, Ruden and Jaeckle, 1995, Rothe et al., 1992, Gonzalez-Gaitan et al., 1994)
      Df(3L)rixTi
      (Tremml and Bienz, 1989)
      Df(3L)riXT1
      (Ribeiro et al., 2002, Boube et al., 2000, Irvine and Wieschaus, 1994, Thomas and van Meyel, 2007)
      Df(3L)ri-XT1
       
      Df(3L)XT1
      (Tearle and Nusslein-Volhard, 1987)
      DfriXT1
      (Correia et al., 2003)
      fngDf
      (Thomas and van Meyel, 2007)
      XT1
      (Oro et al., 1989)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 23 )
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        hide Recent research papers ( 1 )
        Thomas and van Meyel, 2007, Development 134(3): 591--600
        The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. [FBrf0192828]
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