A Database of Drosophila Genes & Genomes

 

Aberration Dmel\Df(3R)hhE23

General Information
SymbolDmel\Df(3R)hhE23SpeciesD. melanogaster
NameFlyBase IDFBab0000010
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << hh << bk2 << klg
Sequence coordinates
Deleted segment94A--94D1
Duplicated segment
Computed Breakpoints include 94A;94D1
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
γ ray
 
Class of aberration (relative to progenitor)
chromosomal_deletion
 
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Limits of break 1 from polytene analysis (citation unavailable) Left limit of break 2 from inclusion of hh (FBrf0067338) Right limit of break 2 from non-inclusion of klg (FBrf0067338)
 
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
hh
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
sar1
(Spradling et al., 1999)
Dph5
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
lmd
(Ruiz-Gomez et al., 2002)
cnc
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
pnt
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
orb
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
how
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(3)j2B1
(BDGP Project Members, 1994-1999)
l(3)j5C7
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(3)06906
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(3)L3560
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(3)rQ178
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(3)L0580
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
epsin-like
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Heterozygosity for Df(3R)hhE23 results in 0.2% X chromosome nondisjunction and 1.6% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
(Harris et al., 2003)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
The right and left hemispheres of the brain are joined at the midline in the b1 region or separated by an abnormally small space (because of excess cells in this region) in 70% of mutant embryos. The preoral brain commissure shows abnormal defasciculation. The frontal commissure is missing and there is a significant decrease in the area occupied by neuronal nuclei and in the number of glia in the b1 region. In the b2-S3 region of the brain, the longitudinal connectives are disrupted, and the area occupied by the neuronal nuclei and the number of glia are reduced. There is a decrease in the number of apoptotic cells at the dorsal midline of the brain in late stage 13 mutant embryos. The number of brain ganglionic mother cells in stage 11 mutant embryos is decreased compared to wild type.
(Page, 2002)
hide Position Effect Variegation Data
  
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
Joan Hooper.
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      Df(3R)hhE23
       
      hhE23
      (Apidianakis et al., 2001, Heberlein et al., 1993, Basler and Struhl, 1994, )
      Name Synonym
      hedgehogE23
      (Page, 2002)
      Secondary FlyBase IDs
      • FBal0031484
      hide References ( 10 )
      Research paper
      Harris et al., 2003, Genetics 165(2): 637--652
      A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. [FBrf0167662]
      Page, 2002, Development 129(9): 2121--2128
      Inductive patterning of the embryonic brain in Drosophila. [FBrf0146987]
      Ruiz-Gomez et al., 2002, Development 129(1): 133--141
      myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila. [FBrf0141504]
      Apidianakis et al., 2001, Development 128(21): 4361--4370
      Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch. [FBrf0139641]
      Spradling et al., 1999, Genetics 153(1): 135--177
      The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
      Nicholls and Gelbart, 1998, Genetics 149(1): 203--215
      Identification of chromosomal regions involved in decapentaplegic function in Drosophila. [FBrf0102843]
      Basler and Struhl, 1994, Nature 368(6468): 208--214
      Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. [FBrf0068409]
      Heberlein et al., 1993, Cell 75(5): 913--926
      The TGF homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. [FBrf0064498]
      FlyBase analysis
      FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type.
      En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
      Computer file
      BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
      Berkeley Drosophila Genome Project. [FBrf0067338]