Aberration Dmel\C(1)A

General Information
Symbol	Dmel\C(1)A	Species	D. melanogaster
Name	Compound (1) of Armentrout	FlyBase ID	FBab0000079
Feature type	homo_compound_chromosome

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order	\| 1A - 6F2 \| 6F2 - 1A \| 20 - 7A1 \| 7A1 - 20 . \|
Progenitor	C(1)TR94
Mutagen	spontaneous
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles	y¹
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Ring shaped in mitotic metaphase.
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	An apparently completely stable, compound-ring-X chromosome; cannot produce single-X chromosome derivative by heterochromatic exchange.
Stocks ( 20 )
Bloomington	1954 C(1)A, y¹/Y/FM0 56 ac^Hw-49c/C(1)A, y¹ 9565 w¹¹⁸ ben¹/C(1)A, y¹ 24167 C(1)A, y¹/y¹ w^* Nrg^l10 5968 Df(1)w-rJ2, ec¹/Dp(1;2;Y)w⁺/C(1)A, y¹ 4621 y¹ w¹ ec¹ s¹ f¹/C(1)A, y¹ 1879 Df(1)GE202/C(1)A, y¹; Dp(1;2)sn⁺72d/Dp(?;2)bw^D, bw^D 2928 T(1;Y)N12, y¹ w¹ f¹: y⁺ B^S/C(1)A, y¹ 2950 T(1;Y)W19, y¹ w¹ f¹: y⁺ B^S/C(1)A, y¹ 3060 T(1;Y)V24, y¹ w¹ f¹: y⁺ B^S/C(1)A, y¹ 3158 T(1;Y)F12, y¹ w¹ f¹: y⁺ B^S/C(1)A, y¹
Kyoto	107825 y¹ w¹ ec¹ s¹ f¹/C(1)A, y¹
	More stocks available...
Notes on Origin
Discoverer	Armentrout, 1964.
	C(1)TR94 progenitor marked with y cv v sd . y sn g Apparently arose by a process describable as reversed crossing over in region 6F2 - 7A1. Current versions of this chromosome have apparently opened, since they are no longer ring-shaped in metaphase. Shown to have separated at 13E by Traverse and Pardue (1988, Proc. Nat. Acad. Sci. USA 85: 8116-20) such that the new order is 13E - 7A1 \| 7A1 - 20.1 - 6F2 \| 6F2 - 1 \| 20 - 13E \| 13E - 20.1 - 6F2 \| 6F2 - 1 \| 20 - 7A1 \| 7A1 - 13E which are interconvertable by exchange between regions 20 and 13. The newly terminal ends at 13E have acquired moderately repeated sequences (He-T DNA) ordinarily encountered at telomeres and in the chromocenter (Traverse and Pardue). Transmission of C(1)A is reduced owing to the fact that half of meiotic exchanges lead to the production of dicentric chromosomes.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The C(1)A chromosome has spontaneously opened in polytene region 13E to produce two new telomeres. Each of the new telomeres has acquired HeT-A DNA sequences. (Traverse and Pardue, 1988) Should be the best of all compound-X chromosomes for stock purposes. Probably originally heterozygous for cv¹, sn¹, v¹, g¹, and sd¹.
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	C(1)A (Tang and Presgraves, 2009)
Name Synonym	Compound (1) of Armentrout
Secondary FlyBase IDs

References ( 7 )
Research paper	Tang and Presgraves, 2009, Science 323(5915): 779--782 Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities. [FBrf0206719] Abad et al., 2000, Mol. Gen. Genet. 264(4): 371--377 Pericentromeric regions containing 1.688 satellite DNA sequences show anti-kinetochore antibody staining in prometaphase chromosomes of Drosophila melanogaster. [FBrf0132093] Agudo et al., 2000, Chromosoma 109(3): 190--196 A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation. [FBrf0128883] Traverse and Pardue, 1988, Proc. Natl. Acad. Sci. U.S.A. 85: 8116--8120 A spontaneously opened ring chromosome of Drosophila melanogaster has acquired He-T DNA sequences at both new telomeres. [FBrf0048950]
Review	Tyler-Smith and Floridia, 2000, Cell 102(1): 5--8 Many paths to the top of the mountain: diverse evolutionary solutions to centromere structure. [FBrf0130123]
Abstract	Letizia et al., 2001, Europ. Dros. Res. Conf. 17: A18 Looking at centromere inactivation. [FBrf0137894]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]