A Database of Drosophila Genes & Genomes

 

Aberration Dmel\C(1)A

General Information
SymbolDmel\C(1)ASpeciesD. melanogaster
NameCompound (1) of ArmentroutFlyBase IDFBab0000079
Feature typehomo_compound_chromosomeCreated / Updated2006-08-22/2006-08-22
Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
| 1A - 6F2 | 6F2 - 1A | 20 - 7A1 | 7A1 - 20 . |
 
Progenitor
C(1)TR94
 
Mutagen
spontaneous
 
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
y1
 
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Ring shaped in mitotic metaphase.
 
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
An apparently completely stable, compound-ring-X chromosome; cannot produce single-X chromosome derivative by heterochromatic exchange.
 
hide Position Effect Variegation Data
  
hide Stocks ( 40 )
Bloomington
1954
C(1)A, y1/Y & FM0
56
acHw-49c/C(1)A, y1
9565
w118 ben1/C(1)A, y1
24167
C(1)A, y1/y1 w* Nrgl10
1864
T(1;Y)R4, y1 w1 f1: y+/C(1)A, y1
1839
T(1;Y)R44, y1 w1 f1: BS/C(1)A, y1
1880
T(1;Y)R34, y1 w1 f1: y+/C(1)A, y1
3224
T(1;Y)E15, y1 w1: y+ BS/C(1)A, y1
4621
y1 w1 ec1 s1 f1/C(1)A, y1
1449
Ts(1Lt;Y)E5, y1 w1 f1: y+ & C(1)A, y1/0
Kyoto
106601
C(1)A, y1/Y & FM0
107825
y1 w1 ec1 s1 f1/C(1)A, y1
hide Notes on Origin
Discoverer
Armentrout, 1964.
 
C(1)TR94 progenitor marked with y cv v sd . y sn g Apparently arose by a process describable as reversed crossing over in region 6F2 - 7A1. Current versions of this chromosome have apparently opened, since they are no longer ring-shaped in metaphase. Shown to have separated at 13E by Traverse and Pardue (1988, Proc. Nat. Acad. Sci. USA 85: 8116-20) such that the new order is 13E - 7A1 | 7A1 - 20.1 - 6F2 | 6F2 - 1 | 20 - 13E | 13E - 20.1 - 6F2 | 6F2 - 1 | 20 - 7A1 | 7A1 - 13E which are interconvertable by exchange between regions 20 and 13. The newly terminal ends at 13E have acquired moderately repeated sequences (He-T DNA) ordinarily encountered at telomeres and in the chromocenter (Traverse and Pardue). Transmission of C(1)A is reduced owing to the fact that half of meiotic exchanges lead to the production of dicentric chromosomes.
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      Should be the best of all compound-X chromosomes for stock purposes. Probably originally heterozygous for cv1, sn1, v1, g1, and sd1.
       
      The C(1)A chromosome has spontaneously opened in polytene region 13E to produce two new telomeres. Each of the new telomeres has acquired HeT-A DNA sequences.
      (Traverse and Pardue, 1988)
      hide Synonyms & Secondary IDs ( 2 )
      Reported As
      Symbol Synonym
      C(1)A
       
      Name Synonym
      Compound (1) of Armentrout
       
      Secondary FlyBase IDs
        hide References ( 6 )
        Research paper
        Abad et al., 2000, Molec. gen. Genet. 264(4): 371--377
        Pericentromeric regions containing 1.688 satellite DNA sequences show anti-kinetochore antibody staining in prometaphase chromosomes of Drosophila melanogaster. [FBrf0132093]
        Agudo et al., 2000, Chromosoma 109(3): 190--196
        A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation. [FBrf0128883]
        Traverse and Pardue, 1988, Proc. Natl. Acad. Sci. USA 85: 8116--8120
        A spontaneously opened ring chromosome of Drosophila melanogaster has acquired He-T DNA sequences at both new telomeres. [FBrf0048950]
        Review
        Tyler-Smith and Floridia, 2000, Cell 102(1): 5--8
        Many paths to the top of the mountain: diverse evolutionary solutions to centromere structure. [FBrf0130123]
        Abstract
        Letizia et al., 2001, Europ. Dros. Res. Conf. 17: A18
        Looking at centromere inactivation. [FBrf0137894]
        Book
        Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
        The Genome of Drosophila melanogaster. [FBrf0066905]