Aberration Dmel\C(4)RM

General Information
Symbol	Dmel\C(4)RM	Species	D. melanogaster
Name		FlyBase ID	FBab0000159
Feature type	homo_compound_chromosome

Computed Breakpoints include
Sequence coordinates
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles	ci¹ (Ruden et al., 1997) ey^R (Ruden et al., 1997) sv^spa-pol (Ahmad and Golic, 1998)
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Two right arms of chromosome 4 attached proximally to a single centromere.
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Produces haplo-4 and triplo-4 progeny in crosses to normal diplo-4 flies. Tetra-4 flies carrying two copies of C(4)RM exhibit but slightly reduced viability (Grell, 1972, D. I. S. 48: 69). Segregates quasi-regularly from C(1)RM in C(1)RM/0; C(4)RM/0 females (Grell, 1963, Genetics 48: 1217-29).
Stocks ( 6 )
Bloomington	1785 C(4)RM, ci¹ ey^R/0 3698 y¹ v¹; C(4)RM, sv^spa-pol 1611 y¹ pn¹; C(4)RM, ci¹ ey^R/0 4406 y¹; ry⁵⁰⁶; C(4)RM, ci¹ ey^R/0 1612 C(1)RM, y¹ v¹ bb¹/0; C(4)RM, ci¹ ey^R/0 & C(1;Y)1, v¹ f¹ B¹/0; C(4)RM, ci¹ ey^R/0
Kyoto	106720 C(4)RM, ci¹ ey^R/0
Notes on Origin
Discoverer	E. B. Lewis.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Exists with different markers; presumably these are different syntheses. Exists with various marker combinations.
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	C(4)EN (Tomkiel et al., 2001, Moore et al., 1994, Hartl et al., 2008) C(4)RM (Haynes et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 16 )
Research paper	Hartl et al., 2008, PLoS Genet. 4(10): e1000228 Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis. [FBrf0206059] Haynes et al., 2007, Genetics 175(3): 1539--1542 A distinct type of heterochromatin within Drosophila melanogaster chromosome 4. [FBrf0200164] Tomkiel et al., 2001, Genetics 157(1): 273--281 The teflon gene is required for maintenance of autosomal homolog pairing at meiosis I in male Drosophila melanogaster. [FBrf0132334] Cox et al., 2000, Genetics 155(4): 1725--1740 A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog. [FBrf0129777] Sousa-Neves, 2000, D. I. S. 83: 8--10 The synthesis of a double fourth chromosome marked with y⁺. [FBrf0135565] Basu et al., 1999, J. Cell Biol. 146(1): 13--28 Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. [FBrf0109303] Ahmad and Golic, 1998, Genetics 148(2): 775--792 The transmission of fragmented chromosomes in Drosophila melanogaster. [FBrf0101865] Halder et al., 1998, Development 125(12): 2181--2191 Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. [FBrf0103272] Starr et al., 1998, J. Cell Biol. 142(3): 763--774 ZW10 helps recruit dynactin and dynein to the kinetochore. [FBrf0104517] Ruden et al., 1997, Dev. Biol. 191(2): 284--296 A Drosophila kinesin-like protein (Klp38B) functions during meiosis, mitosis, and segmentation. [FBrf0099905] Locke and Tartof, 1994, Molec. gen. Genet. 243(2): 234--243 Molecular analysis of cubitus interruptus (ci) mutations suggests an explanation for the unusual ci position effects. [FBrf0073755] Moore et al., 1994, Genetics 136(3): 953--964 Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males. [FBrf0073960] Hall and Kankel, 1976, Genetics 83: 517--535 Genetics of acetylcholinesterase in Drosophila melanogaster. [FBrf0028767] Grell, 1972, D. I. S. 48: 69 Viability of tetra-4 flies. [FBrf0023684] Grell, 1963, Genetics 48(9): 1217--1229 Distributive pairing of compound chromosomes in females of Drosophila melanogaster. [FBrf0015566]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]