Aberration Dmel\Df(1)260-1

General Information
Symbol	Dmel\Df(1)260-1	Species	D. melanogaster
Name		FlyBase ID	FBab0000224
Feature type	chromosomal_deletion

Computed Breakpoints include	1A1;1B4
Deleted segment	1A1--1B4
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous
Class of aberration (relative to progenitor)	chromosomal_deletion (Garcia-Bellido and Robbins, 1983, Pauli et al., 1995, White et al., 1983, Duffy et al., 1996, Kimura et al., 1985, Sutton, 1943)
Breakpoints	1A1;1B3-1B4 (Sutton, 1943) 1A1;1B4-1B6 (Pauli et al., 1995, Duffy et al., 1996) 1A1;1B4-1B7 (White et al., 1983) [];1B4--6 (Sherald and Voelker, 1985, Ray and Rodrigues, 1994) XLt;1B4-1B6 (Kimura et al., 1985) XLt;1B6-1B7 (Garcia-Bellido and Robbins, 1983)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << pch << Exp6 << bk2 << svr
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Gonzalez et al., 1989, Ruiz-Gomez and Ghysen, 1993)
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0005951) Left limit of break 2 from inclusion of Cyp4g1 (FBrf0054051) Right limit of break 2 from polytene analysis (FBrf0005951)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ac (del Prado and Garcia-Bellido, 1984, Duffy and Gergen, 1991, Sutton, 1943, Ray and Rodrigues, 1994, Giebel et al., 1997) ase (Ray and Rodrigues, 1994) cin (Padilla and Nash, 1977) Cyp4g1 (Duffy and Gergen, 1991, Giebel et al., 1997) l(1)sc (Duffy and Gergen, 1991, Ray and Rodrigues, 1994, Giebel et al., 1997) pch (Kimura et al., 1985) sc (del Prado and Garcia-Bellido, 1984, Duffy and Gergen, 1991, Lai and Mackay, 1993, Sutton, 1943, Ray and Rodrigues, 1994, Giebel et al., 1997) y (Ingham et al., 1985, Sutton, 1943, Ray and Rodrigues, 1994)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	elav (White et al., 1983) fs(1)N (Perez-Chiesa et al., 1983) l(1)1Bl (White et al., 1983) prage (Tadros et al., 2003) rey (Sturtevant, 1948) skpA (Khush et al., 2002) su(b) (Sherald and Voelker, 1985) svr (Sutton, 1943) vnd (White et al., 1983)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fewer cells enlarge in the embryonic ventral neuroectoderm before delamination of the SI neuroblasts compared to wild-type embryos; 33% in the medial, 4% in the intermediate and 11% in the lateral region (wild-type numbers are 63%, 20% and 64% respectively). Prior to the delamination of the SII neuroblasts, when in the wild-type neurectoderm the cells of the intermediate regions enlarge, there is almost no increase in cell size in corresponding regions in Df(1)260-1 embryos. (Stollewerk, 2000)
NOT in combination with other aberrations	Df(1)260-1 clones in the wing margin produce bristles with an abnormal morphology. Thoracic Df(1)260-1 clones are devoid of bristles. Coexpression of sens^Scer\UAS.cNa and da^Scer\UAS.cGa, under the control of Scer\GAL4^Eq1, results in the formation of bristles in these clones. (Jafar-Nejad et al., 2006) The bristle phenotype seen female D.simulans/D.melanogaster hybrids is significantly exacerbated by the Df(1)260-1 deletion, which removes the achaete-scute complex. (Skaer and Simpson, 2000) The ventral cord of hemizygous embryos is strongly fragmented and all external sensory organs of the trunk are missing. Neural hypoplasia of the CNS and PNS are strongly reduced by Scer\GAL4^da.G32-mediated expression of l(1)sc^Scer\UAS.cHa. (Giebel et al., 1997) Df(1)260-1 clones produce normal numbers of olfactory sensilla on the surface of the third antennal segment, although some of these sensilla are smaller than normal and are morphologically abnormal. (Reddy et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Embryos lack all es organs but ch organs develop normally (FBrf0046281). P{hsp(sE)-poxn} expression can lead to the formation of external structures typical of es organs. (Vervoort et al., 1995) Hemizygous clones in the labellum lack all taste bristles; the taste pegs as well as the pseudotracheal structures are absent. (Ray and Rodrigues, 1994) In heterozygous females the deletion acts as a dominant suppressor of h and emc. All es and most of the nd neurons are removed, ch neurons are not affected. (del Prado and Garcia-Bellido, 1984) homozygous lethal (Garcia-Bellido and Robbins, 1983) Lethal in homozygous and hemizygous condition. (Sutton, 1943) male lethal somatic cell viable Germ-line clones lethal (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). Eliminates all external sense organs in embryo (Dambly-Chaudiere and Ghysen, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 222-28).
Stocks ( 2 )
Bloomington	722 Df(1)260-1, y¹/FM4
Kyoto	106044 Df(1)260-1, y¹/FM4
Notes on Origin
Discoverer	Demerec and Hoover, 1936. (Sutton, 1943)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(1)0-sc,LVM Df(1)260-1 (Jafar-Nejad et al., 2006) Df(1)260.1 (Nelson and Laughon, 1994, Leyns et al., 1996, Dambly-Chaudiere and Leyns, 1992, Ingham et al., 1985, Vervoort et al., 1995, Kramatschek and Campos-Ortega, 1994, Ghysen and O'Kane, 1989) Df(1)^260-1 (Sugaya et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 49 )

Generate a list of	All references relating to this aberration ( 49 )

List References by type	Research paper ( 45 ) Review ( 2 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
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Recent reviews (0)
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