|Name||Deficiency (1) Bar||FlyBase ID||FBab0000327|
|Also Known As||Df(1)B263-20, Df(1)Bar263-20|
|Computed Breakpoints include||15F1-15F2;16A7|
|Member of large scale dataset(s)|
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|Nature of the Aberration|
|Class of aberration (relative to progenitor)|
|Formalized genetic data||baz << bk1 << l(1)15Fa << B << bk2 << ff|
|Genetic mapping information|
|Comments on Cytology|
Band 16A7 of the second repeat of the 16A region may not have been deleted.
|Gene Deletion & Duplication Data|
|Genes Deleted / Disrupted|
|Completely deleted / disrupted|
|Genes NOT Deleted / Disrupted|
|Genes NOT Duplicated|
|In combination with other aberrations|
No defect in the gross morphology of distal legs is seen when Df(1)B clones are induced in flies carrying Dp(1;Y)BS.
|NOT in combination with other aberrations|
Somatic clones homozygous for Df(1)B in the tarsal segments cause fusion of tarsal segments 2-5. This phenotype is not suppressed by apScer\UAS.cOa; Scer\GAL4Dll-md23.
Homozygous embryos have normal gut morphology.
In gynandromorphs, in legs totally composed of cells hemizygous for Df(1)B, tarsal segments 2-5 are fused together into a small bulb-like, non-segmental structure having neither claws nor pulvilli, whereas other leg segments are normal. No central folding occurs in Df(1)B leg discs (in contrast to wild type), although more proximal folds are normally formed. Partial fusion of tarsal segments 2-5 is frequently seen when small Df(1)B clones are induced in the leg. Clones in the leg disc along the periphery of the early ring of B-H1 and B-H2 expression prevent central fold formation in the disc. Clones within tarsal segments 4 and 5 are occasionally associated with campaniform sensilla (normally found only at the dorsodistal tip of tarsal segment 3) and ectopic joint material is seen. In mosaic legs (containing Df(1)B clones) which have normal appearance, all mutant clones are outside tarsal segments 3-5, except for a single case in which a Df(1)B bristle was situated at the proximal tip of tarsal segment 3. No central fold formation is seen in the antennal disc in gynandromorphs in which the antennal disc is hemizygous for Df(1)B. Df(1)B antennae frequently lack the arista and basal cylinder.
Few microchaetae are generated in mutant clones in the prescutum. PS macrochaetae do not develop in mutant clones
Midgut development of mutant embryos is wild type.
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
Hemizygous embryos were examined with polarised light microscopy and antibody staining and found to have wild type muscle pattern and contraction.
Hemizygotes die at an early larval stage.
The deleted region also contains X1 and T1/T2 units not relevant to eye morphogenesis and X2, an uncharacterized unit. Flies deficient for the Bar region have unpatterned, excess cells in the interommatidial space. The secondary effects of this is extensive distortions in rhadomere structure. The absence of Bar may result in aberrant lens formation.
Eyes are wild type. Lethal in homozygous and hemizygous condition.
|Stocks ( 2 )|
|Notes on Origin|
M. Demerec, Jan. 1934.
|Balancer / Genotype Variants of the Aberration|
Lethal and cell-lethal.
|Synonyms & Secondary IDs ( 9 )|
Deficiency (1) Bar
|Secondary FlyBase IDs|
|References ( 33 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|