Aberration Dmel\Df(1)B

General Information
Symbol	Dmel\Df(1)B	Species	D. melanogaster
Name	Deficiency (1) Bar	FlyBase ID	FBab0000327
Feature type	chromosomal_deletion
Also Known As	Df(1)B^263-20, Df(1)Bar^263-20

Computed Breakpoints include	15F1-15F2;16A7
Deleted segment	15F1--16A7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	B¹ Dp(1;1)B (Sutton, 1943)
Mutagen	X ray (Sutton, 1943)
Class of aberration (relative to progenitor)	chromosomal_deletion (Ferrus et al., 1990, Pauli et al., 1995, McKim et al., 1996, Cook et al., 1997, Sutton, 1943)
Breakpoints	15F1-15F2;16A7-16B1 (Ferrus et al., 1990) 15F9-16A1;16A6-16A7 (McKim et al., 1996) 15F9;16A7 (Pauli et al., 1995) 16A2;16A6 (Cook et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	baz << bk1 << l(1)15Fa << B << bk2 << ff
Genetic mapping information
Comments	210kb deletion. (Higashijima et al., 1992)
Comments on Cytology
	Ref: FBrf0056098. (McKim et al., 1996) Band 16A7 of the second repeat of the 16A region may not have been deleted. (Sutton, 1943) Limits of break 1 from polytene analysis (FBrf0051942) Left limit of break 2 from polytene analysis (FBrf0051942) Right limit of break 2 from polytene analysis (FBrf0080317)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	B (Higashijima et al., 1992, Higashijima et al., 1992, Sutton, 1943, McKim et al., 1996) B-H1 (Kojima et al., 2000) B-H2 (Kojima et al., 2000, Higashijima et al., 1992, Higashijima et al., 1992) f (McKim et al., 1996, Dickinson and Thatcher, 1997) l(1)15Fa (McKim et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	baz (McKim et al., 1996) if (McKim et al., 1996) l(1)15Bb (McKim et al., 1996) l(1)15Bc (McKim et al., 1996) l(1)15Da (McKim et al., 1996) l(1)15Db (McKim et al., 1996) l(1)15Dc (McKim et al., 1996) l(1)15Dd (McKim et al., 1996) l(1)15De (McKim et al., 1996) l(1)15Eb (McKim et al., 1996) mei-218 (McKim et al., 1996) mit (Gelbart, 1974) r (McKim et al., 1996) RpS5a (McKim et al., 1996) xmas-1 (McKim et al., 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No defect in the gross morphology of distal legs is seen when Df(1)B clones are induced in flies carrying Dp(1;Y)B^S. (Kojima et al., 2000) Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Df(1)B has no effect on transmission. (Cook et al., 1997)
NOT in combination with other aberrations	Somatic clones homozygous for Df(1)B in the tarsal segments cause fusion of tarsal segments 2-5. This phenotype is not suppressed by ap^Scer\UAS.cOa; Scer\GAL4^Dll-md23. (Pueyo and Couso, 2004) Homozygous embryos have normal gut morphology. (Merabet et al., 2002) In gynandromorphs, in legs totally composed of cells hemizygous for Df(1)B, tarsal segments 2-5 are fused together into a small bulb-like, non-segmental structure having neither claws nor pulvilli, whereas other leg segments are normal. No central folding occurs in Df(1)B leg discs (in contrast to wild type), although more proximal folds are normally formed. Partial fusion of tarsal segments 2-5 is frequently seen when small Df(1)B clones are induced in the leg. Clones in the leg disc along the periphery of the early ring of B-H1 and B-H2 expression prevent central fold formation in the disc. Clones within tarsal segments 4 and 5 are occasionally associated with campaniform sensilla (normally found only at the dorsodistal tip of tarsal segment 3) and ectopic joint material is seen. In mosaic legs (containing Df(1)B clones) which have normal appearance, all mutant clones are outside tarsal segments 3-5, except for a single case in which a Df(1)B bristle was situated at the proximal tip of tarsal segment 3. No central fold formation is seen in the antennal disc in gynandromorphs in which the antennal disc is hemizygous for Df(1)B. Df(1)B antennae frequently lack the arista and basal cylinder. (Kojima et al., 2000) Few microchaetae are generated in mutant clones in the prescutum. PS macrochaetae do not develop in mutant clones (Sato et al., 1999) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Hemizygous embryos were examined with polarised light microscopy and antibody staining and found to have wild type muscle pattern and contraction. (Drysdale et al., 1993) Hemizygotes die at an early larval stage. (Higashijima et al., 1992) The deleted region also contains X1 and T1/T2 units not relevant to eye morphogenesis and X2, an uncharacterized unit. Flies deficient for the Bar region have unpatterned, excess cells in the interommatidial space. The secondary effects of this is extensive distortions in rhadomere structure. The absence of Bar may result in aberrant lens formation. (Higashijima et al., 1992) Eyes are wild type. Lethal in homozygous and hemizygous condition. (Sutton, 1943) Male lethal.
Stocks ( 2 )
Bloomington	723 Df(1)B/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴
Kyoto	106045 Df(1)B/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴
Notes on Origin
Discoverer	M. Demerec, Jan. 1934. Demerec, 1934. (Sutton, 1943)
	Revertant. (Bridges and Brehme, 1944) Revertant
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Lethal and cell-lethal. (Bridges and Brehme, 1944)
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	B (Sanchez et al., 1994) B263-20 (Sutton, 1943) B^263-20 Df(1)B (Crest et al., 2007) Df(1)B263-20 (Higashijima et al., 1992, ) Df(1)B^263-20 (Pueyo and Couso, 2004, Lim and Choi, 2003, Kojima et al., 2000, Gelbart, 1974, Sato et al., 1999, Dickinson and Thatcher, 1997, Ferrus et al., 1990, Ishimaru and Saigo, 1993, Higashijima et al., 1992) Df(1)Bar263 (Galindo et al., 2002) Df(1)Bar^263-20 (Singh et al., 2005, Sakurai et al., 2007)
Name Synonym	Deficiency (1) Bar
Secondary FlyBase IDs
	FBal0000828
References ( 33 )

Generate a list of	All references relating to this aberration ( 33 )

List References by type	Research paper ( 29 ) Supplementary material ( 1 ) FlyBase analysis ( 1 ) Book ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...