Aberration Dmel\Df(1)C52

General Information
Symbol	Dmel\Df(1)C52	Species	D. melanogaster
Name		FlyBase ID	FBab0000359
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	lz << bk1 << btd << bk2 hits flw
Sequence coordinates
Deleted segment	8E4--9C4
Duplicated segment
Computed Breakpoints include	8E4;9C1-9C4
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Cohen and Jurgens, 1990, Wimmer et al., 1993, Deak et al., 1982, Gordesky-Gold et al., 1995, Pauli et al., 1995, Mason et al., 1981, Duffy et al., 1996, Landecker et al., 1994, Anand and Chandra, 1994, Batterham et al., 1996, Craymer and Roy, 1980)
Breakpoints	8E;9C-9D (Craymer and Roy, 1980, Landecker et al., 1994, Anand and Chandra, 1994, Gordesky-Gold et al., 1995, Pauli et al., 1995, Duffy et al., 1996, Batterham et al., 1996) 8F3;9D6 (Mason et al., 1981) 8E;9D (Deak et al., 1982) 8E4;9C (Cohen and Jurgens, 1990, Wimmer et al., 1993)
Causes alleles	flw^C52 (Deak et al., 1982)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0052647) Left limit of break 2 from polytene analysis (FBrf0034402) Right limit of break 2 from non-inclusion of flw (FBrf0038305)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	btd (Cohen and Jurgens, 1990, Wimmer et al., 1993, Schock et al., 1999) Sp1 (Schock et al., 1999) nej (Florence and McGinnis, 1998) Yp1 (Postlethwait and Shirk, 1981, Minoo and Postlethwait, 1985, Bownes et al., 1991, Butterworth et al., 1992, Giorgi et al., 1993) Yp2 (Bownes et al., 1991, Butterworth et al., 1992, Giorgi et al., 1993) lphA (Gordesky-Gold et al., 1995) mus109 (Baker and Smith, 1979, Mason et al., 1981) fliF (Deak et al., 1982)
Partially deleted / disrupted	flw (Deak et al., 1982)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	lz (Batterham et al., 1996) flw (Craymer and Roy, 1980) ras (Barbash et al., 2000) Hmr (Barbash et al., 2000, Barbash et al., 2003) v (Barbash et al., 2000) sbr (Barbash et al., 2000) sesB (Barbash et al., 2000) mus101 (Mason et al., 1981) mei-41 (Mason et al., 1981) l(1)9Fl (Barbash et al., 2000) l(1)9Fk (Barbash et al., 2000) fliK (Barbash et al., 2000) gl-l (Popkova, 2004.2.27) l(1)9Ec (Barbash et al., 2000)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 50% of run³ heterozygotes. (Duffy et al., 1996) Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation. (Bilder and Scott, 1995) Embryos hemizygous for Df(1)C52 have a stronger lateral pentascolopidial chordotonal organ (lch5) phenotype than btd alleles, developing up no more than two scolopidia per chordotonal organ, and often developing none. (Schock et al., 1999) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygous larvae have a negative photokinetic stimulus indice similar to wild type and transheterozygotes with lphA² have an extremely high indice, they are blind. (Gordesky-Gold et al., 1995) More than six-fold reduction in sex ratio and significant levels of female lethality is observed when in combination with Sxl^f1. Female lethality is also reduced when in combination with da¹ but restored when in combination with emc^ML. (Anand and Chandra, 1994) Mutant wing position of fliF and flw uncovered in deficiency heterozygotes. No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The Keilin\'s organs are absent in mutants. Homozygous mutant clones induced the larval period fail to survive. (Estella et al., 2003)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	952 Df(1)C52, flw^C52/FM6
Kyoto	108931 Df(1)C52, flw^C52/FM6
Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	flw alleles are lethal over Df(1)v-L15 but viable over Df(1)C52, with a flap-wing phenotype. (Deak et al., 1982)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	C52 (Sanchez et al., 1994) df(1)C52 (Butterworth et al., 1991) Df(1)C52 (Crest et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 43 )

Generate a list of	All references relating to this aberration ( 43 )

List References by type	Research paper ( 39 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...