Aberration Dmel\Df(1)DA622

General Information
Symbol	Dmel\Df(1)DA622	Species	D. melanogaster
Name		FlyBase ID	FBab0000369
Feature type	chromosomal_deletion

Computed Breakpoints include	10B8;10D2
Deleted segment	10B8--10D2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Watson et al., 1991)
Breakpoints	10B6-10B8;10D2 (Watson et al., 1991)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	hop << bk1 << dlg1 << l(1)10Bi << bk2
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Woods and Bryant, 1989, Woods and Bryant, 1991)
Comments on Cytology
	Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of dlg1 (FBrf0049482) Limits of break 2 from polytene analysis (FBrf0053739)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	dlg1 (Woods and Bryant, 1989, Caggese et al., 1994) Gs2 (Caggese et al., 1994) l(1)10Bg (Woods and Bryant, 1989, Caggese et al., 1994) l(1)10Bh (Woods and Bryant, 1989, Caggese et al., 1994) l(1)10Bi (Woods and Bryant, 1989, Caggese et al., 1994) l(1)10Bj (Woods and Bryant, 1989, Caggese et al., 1994) roX2 (Franke and Baker, 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	dsh (Woods and Bryant, 1989, Caggese et al., 1994) hop (Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Binari and Perrimon, 1994, Caggese et al., 1994) l(1)10Ba (Woods and Bryant, 1989) l(1)10Bb (Woods and Bryant, 1989) l(1)10Bc (Woods and Bryant, 1989, Caggese et al., 1994)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	hemizygous late embryonic lethal (Franke and Baker, 1999)
Stocks ( 0 )

Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Distal breakpoint molecularly mapped. (Woods and Bryant, 1989)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(1)DA622
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Franke and Baker, 1999, Mol. Cell 4(1): 117--122 The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila. [FBrf0109730] Binari and Perrimon, 1994, Genes Dev. 8(3): 300--312 Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. [FBrf0068418] Hanratty and Dearolf, 1993, Mol. Gen. Genet. 238(1-2): 33--37 The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. [FBrf0059077] Watson et al., 1991, Dev. Genet. 12: 173--187 Lethal(1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster. [FBrf0053739] Woods and Bryant, 1991, Cell 66: 451--464 The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. [FBrf0053375] Perrimon et al., 1989, Genetics 121: 333--352 Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. [FBrf0049894] Woods and Bryant, 1989, Dev. Biol. 134: 222--235 Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila. [FBrf0049482] Kulkarni and Hall, 1987, Genetics 115: 461--475 Behavioral and cytogenetic analysis of the cacophony courtship song mutant and interacting genetic variants in Drosophila melanogaster. [FBrf0046378] Perrimon and Mahowald, 1986, Dev. Biol. 118: 28--41 l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. [FBrf0044150]
Review	Caggese et al., 1994, Genetica 94(2-3): 275--281 Genetic, molecular and developmental analysis of the glutamine synthetase isozymes of Drosophila melanogaster. [FBrf0079921] Gateff and Mechler, 1989, Crit. Rev. Oncogen. 1: 221--245 Tumor-suppressor genes of Drosophila melanogaster. [FBrf0049455]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]