FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(1)DCB1-35b
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General Information
Symbol
Df(1)DCB1-35b
Species
D. melanogaster
Name
FlyBase ID
FBab0000370
Feature type
chromosomal_deletion
Also Known As
DCB1-35b
Computed Breakpoints include

19F1;20F1-h26

Features within 19F1--h26
Genomic Maps
Sequence coordinates
X:20,939,503..21,345,088 (Df(1)DCB1-35b:bk1)
(Cook, 2016.2.8)
X:22,980,722..23,544,271 (Df(1)DCB1-35b:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
3H-thymidine
3H-deoxycytidine
(Schalet and Lefevre, 1973)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Harbecke and Lengyel, 1995, Pauli et al., 1995, Anand and Chandra, 1994, Yamamoto et al., 1990, Perrimon et al., 1989, Deak et al., 1982, Craymer and Roy, 1980, Schalet and Lefevre, 1973)
Breakpoints

19F1--2;[]

(Schalet and Lefevre, 1973)

19F1;20F

(Perrimon et al., 1989, Craymer and Roy, 1980)

19F;20F

(Deak et al., 1982)

19E8;XLt-XRt

(Yamamoto et al., 1990)

19F1-19F2;20E-20F

(Harbecke and Lengyel, 1995, Pauli et al., 1995, Anand and Chandra, 1994)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

unc << bk1 << lfl << su(f) << bk2 << bb

Genetic mapping information
Comments

The X:20939503..21345088 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of Npc1b, which published results say is not deleted. The right extent corresponds to the right end of fliI, which published results say is deleted.

(Cook, 2016.2.8)

The X:22980722..23544271 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left ends of the overlapping stnA and stnB genes, which published results say are deleted. The right extent corresponds to the right end of the X chromosome assembled sequence, because some published results suggest Df(1)DCB1-35b extends into X heterochromatin

(Cook, 2016.2.8)
Comments on Cytology

Right breakpoint is far to the right of 20A.

(Schalet and Lefevre, 1973)

Left limit of break 1 from polytene analysis (FBrf0024685) Right limit of break 1 from polytene analysis (FBrf0034402) Left limit of break 2 from polytene analysis (FBrf0034402) Right limit of break 2 from non-inclusion of bb (FBrf0024685)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
bb
(Zusman et al., 1985)
COM
(Desset et al., 2003)
Ddx56
(Prud'homme et al., 1995, Perrimon et al., 1989)
eor
(Prud'homme et al., 1995, Perrimon et al., 1989, Zusman et al., 1985)
fliI
(Perrimon et al., 1989, Deak et al., 1982)
fog
(Harbecke and Lengyel, 1995, Perrimon et al., 1989, Zusman et al., 1985)
intro
(Prud'homme et al., 1995, Perrimon et al., 1989, Zusman et al., 1985, Schalet and Lefevre, 1973)
l(1)19Fb
(Perrimon et al., 1989, Schalet and Lefevre, 1973)
l(1)20Ca
(Perrimon et al., 1989, Schalet and Lefevre, 1973)
l(1)20Cb
(Perrimon et al., 1989, Zusman et al., 1985, Schalet and Lefevre, 1973)
lfl
(Perrimon et al., 1989, Gergen and Wieschaus, 1986, Schalet and Lefevre, 1973, Schalet, 1972)
lncRNA:flam
(Prud'homme et al., 1995)
mst
(Prud'homme et al., 1995, Perrimon et al., 1989)
slgA
(Perrimon et al., 1989)
sol
(Perrimon et al., 1989)
soz
(Perrimon et al., 1989)
sph
(Perrimon et al., 1989, Schalet and Lefevre, 1973)
stnA
(Perrimon et al., 1989, Zusman et al., 1985, Schalet and Lefevre, 1973)
stnB
(Perrimon et al., 1989, Zusman et al., 1985)
su(f)
(Prud'homme et al., 1995, Perrimon et al., 1989, Gergen and Wieschaus, 1986, Craymer and Roy, 1980, Schalet and Lefevre, 1973)
tuh1
(Prud'homme et al., 1995, Perrimon et al., 1989)
uncl
(Perrimon et al., 1989, Zusman et al., 1985, Schalet and Lefevre, 1973)
wap
(Prud'homme et al., 1995, Perrimon et al., 1989, Zusman et al., 1985, Schalet and Lefevre, 1973)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (181)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Homozygous embryos have abnormal gut morphology; visceral mesoderm cells do not migrate dorsoventrally and dorsal midgut closure fails.

(Merabet et al., 2002)

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

(Halsell and Kiehart, 1998)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Homozygous embryos are very abnormal compared to wild-type.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

(Pauli et al., 1995)

No significant change in female lethality when in combination with Sxlf1.

(Anand and Chandra, 1994)

Hemizygous embryos were examined with polarised light microscopy and antibody staining: muscle pattern and activity wild type within the constraints imposed by the body plan defect caused by the deletion of fog.

(Drysdale et al., 1993)
Stocks (2)
Notes on Origin
Discoverer

Kaplan.

 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

Distal heterochromatic regions are intact on the Df(1)DCB1-35b chromosome. Second breakpoint not reported.

(Yamamoto et al., 1990)
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
DCB1-35b
(Sanchez et al., 1994, Schalet and Lefevre, 1973)
Df(1)DCB-1-35b
(Anand and Chandra, 1994)
Df(1)DCB1
(Tearle and Nusslein-Volhard, 1987)
Df(1)DCB1-35b
(Li et al., 2020, Sawyer et al., 2020, Morriss et al., 2013, Crest et al., 2007)
Name Synonyms
Secondary FlyBase IDs
    References (36)