Aberration Dmel\Df(1)GA104

General Information
Symbol	Dmel\Df(1)GA104	Species	D. melanogaster
Name		FlyBase ID	FBab0000391
Feature type	chromosomal_deletion

Computed Breakpoints include	19F2-19F3;19F6
Deleted segment	19F2--19F6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Miklos et al., 1987)
Class of aberration (relative to progenitor)	chromosomal_deletion
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(1)19Fb << bk1 << tty << mst << bk2 << tuh1
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of l(1)19Fb (FBrf0046783) Right limit of break 1 from inclusion of fliI (FBrf0046783) Left limit of break 2 from inclusion of mst (FBrf0046783) Right limit of break 2 from non-inclusion of tuh1 (FBrf0049891)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	dod (Maleszka et al., 1996) fliI (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, de Couet et al., 1995, Maleszka et al., 1996) Hlc (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) mst (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) pen (Maleszka et al., 1996) slgA (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) sol (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) tty (Maleszka et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	eo (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) fog (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) intro (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) l(1)19Ed (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) l(1)19Fb (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) l(1)20Ca (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) l(1)20Cb (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) lf (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) lfl (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) mal (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) mell (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) Npc1b (Perrimon et al., 1989, Miklos et al., 1987, Miklos and de Couet, 1990) run (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) shakB (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) soz (Perrimon et al., 1989, Miklos and de Couet, 1990) sph (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) stnA (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) stnB (Perrimon et al., 1989) su(f) (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) tuh1 (Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) unc (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) uncl (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) vao (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) wap (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(1)16-129/Df(1)GA104 animals (in which fliI function is rescued by fliI^FLI) are viable. Females produce a ventralised eggshell phenotype, which has 35% penetrance at 25^oC and ranges in expressivity from fused dorsal appendages to no appendages at all. At 30^oC, the penetrance is 99% and at 18^oC the penetrance is 3%. Embryos produced from Df(1)16-129/Df(1)GA104 females (in which fliI function is rescued by fliI^FLI) mated to wild-type males show cuticle patterning defects; expanded and fused ventral denticles. (Hsu et al., 2001) fliI^FLI Df(1)16-129/fliI^FLI Df(1)GA104 individuals are 76% viable and 93% of survivors can fly normally. (Maleszka et al., 1996) Lethal in combination with Df(1)16-129. (Miklos and de Couet, 1990)
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	5989 Df(1)GA104/FM7c/Dp(1;Y)y⁺mal¹⁰⁶
Kyoto	108530 Df(1)GA104/FM7c/Dp(1;Y)y⁺mal¹⁰⁶
Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(1)GA104 GA104 (Maleszka et al., 1998)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Hsu et al., 2001, Nat. Cell Biol. 3(6): 538--543 Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. [FBrf0137058] Maleszka et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95(7): 3731--3736 Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila. [FBrf0101952] Maleszka et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93(1): 447--451 The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae. [FBrf0085507] de Couet et al., 1995, Genetics 141(3): 1049--1059 Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster. [FBrf0083951] Miklos and de Couet, 1990, J. Neurogenet. 6(3): 133--151 The mutations previously designated as flightless-I3, flightless-O2 and standby are members of the W-2 lethal complementation group at the base of the X-chromosome of Drosophila melanogaster. [FBrf0052388] Perrimon et al., 1989, Genetics 121: 313--331 Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. [FBrf0049891] Miklos et al., 1987, J. Neurogenet. 4: 1--19 Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster. [FBrf0046783]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]