Aberration Dmel\Df(1)KA14

General Information
Symbol	Dmel\Df(1)KA14	Species	D. melanogaster
Name		FlyBase ID	FBab0000483
Feature type	chromosomal_deletion

Computed Breakpoints include	7F1;8C6
Deleted segment	7F1--8C6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Perrimon et al., 1989, Spradling et al., 1994, Wieschaus et al., 1984, Deak et al., 1982, Bieber et al., 1989, Pauli et al., 1995, Duffy et al., 1996, King et al., 1986, Silva et al., 1991, Lineruth et al., 1985, Helfand and Carlson, 1989, Inoue et al., 1989, Cook et al., 1997, Watson et al., 1991, Harbecke and Lengyel, 1995, Landecker et al., 1994, Anand and Chandra, 1994, Min and Benzer, 1997, Craymer and Roy, 1980, Porsch et al., 1998)
Breakpoints	7D10-7D11;8C6 (Spradling et al., 1994) 7F1-7F2;8C5 (Bieber et al., 1989) 7F1-7F2;8C6 (Craymer and Roy, 1980, Deak et al., 1982, Wieschaus et al., 1984, Lineruth et al., 1985, King et al., 1986, Perrimon et al., 1989, Inoue et al., 1989, Watson et al., 1991, Silva et al., 1991, Smith et al., 1993, Landecker et al., 1994, Wojcik et al., 1994, Anand and Chandra, 1994, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Cook et al., 1997, Porsch et al., 1998) 7F1;8C6 (Helfand and Carlson, 1989, Min and Benzer, 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	lix << bk1 << su(Cbx) << l(1)7Fd << bk2 << fliD
Genetic mapping information
Comments
Comments on Cytology
	Ref: Craymer and Roy, 1980, D. I. S. 55: 200--204 (Wieschaus et al., 1984) Left limit of break 1 from polytene analysis (FBrf0034402) Right limit of break 1 from inclusion of Nrg (FBrf0044177) Limits of break 2 from polytene analysis (FBrf0034402)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	e(r) (Wojcik et al., 1994) gg (Craymer and Roy, 1980) Lim1 (Lilly et al., 1999) Moe (Jankovics et al., 2002) Nrg (King et al., 1986, Bieber et al., 1989, Kerr et al., 1997) oc (Craymer and Roy, 1980, Tearle and Nusslein-Volhard, 1987, Cohen and Jurgens, 1990, Schmidt-Ott et al., 1994, Harbecke and Lengyel, 1995, Wimmer et al., 1995, van den Dries et al., 1996, Luer et al., 1997) otu (King et al., 1986, Pauli et al., 1993) pt (King et al., 1986) ptg (Craymer and Roy, 1980, Helfand and Carlson, 1989) rdgA (Harris and Stark, 1977)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	dec-1 (Lineruth et al., 1985) eggroll (Min and Benzer, 1997) fs(1)h (Florence and McGinnis, 1998) gl-l (Popkova, 2004.2.27) lawc (Zorin et al., 1999) lix (Silva et al., 1991) mei-P26 (Page et al., 2000, Glasscock et al., 2005) sdt (Tearle and Nusslein-Volhard, 1987) wiser (Mela et al., 2009)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Df(1)KA14 has no effect on transmission. (Cook et al., 1997)
NOT in combination with other aberrations	Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Most of the VUM neurons and also the median neuroblast degenerate. Midline glial cells fail to migrate posteriorly, but this may be an indirect effect due to the absence of VUM neurons. Dorsal medial cell numbers correspond to wild type. Thus midline neurons appear to be dispensible with regard to dorsal meidal cell formation. (Luer et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Homozygous embryos have reduced heads compared to wild-type. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) The Bolwig organ, hypopharyngeal organ and laterohypopharyngeal organ are absent in homozygous embryos. The frontal ganglion and frontal connective are shifted anteriorly. The supraoesophageal ganglion is reduced in size and no supraoesophageal commissure forms. The optic lobes are almost completely deleted. (Schmidt-Ott et al., 1995) More than six-fold reduction in sex ratio and significant levels of female lethality is observed when in combination with Sxl^f1. Female lethality is also reduced when in combination with da¹ but restored when in combination with emc^ML. (Anand and Chandra, 1994) Ocular segment, dorsomedial papilla, pharyngeal sense organ, Bolwig's organ, antennal sense organ and pharyngeal monoscolopidial chordotonal organ are deleted. (Schmidt-Ott et al., 1994) Hemizygous embryos were examined with polarised light microscopy and antibody staining: indistinct striations and altered staining properties in antibody assay. (Drysdale et al., 1993) Heterozygotes have ocelli placed far back on the head and there is a slight indentation in the cuticle beneath the postvertical bristles. (Craymer and Roy, 1980) Germ-line clones lethal (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47)
Stocks ( 2 )
Bloomington	951 Df(1)KA14/FM7c
Kyoto	108930 Df(1)KA14/FM7c
Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Def(1)KA14 (Neuman-Silberberg, 2007) Df(1)951 (Mela et al., 2009) Df(1)KA12 (Korey and MacDonald, 2003) Df(1)KA14 (Crest et al., 2007, Anderson et al., 2006, O'Farrell et al., 2008, Denef et al., 2008, Carhan et al., 2005) Df(2L)KA14 (Tearle and Nusslein-Volhard, 1987) KA14 (Sanchez et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 68 )

Generate a list of	All references relating to this aberration ( 68 )

List References by type	Research paper ( 64 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...