Aberration Dmel\Df(1)KA6

General Information
Symbol	Dmel\Df(1)KA6	Species	D. melanogaster
Name		FlyBase ID	FBab0000484
Feature type	chromosomal_deletion

Computed Breakpoints include	10E1;11A7
Deleted segment	10E1--11A7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Eeken and Sobels, 1990)
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Mason et al., 1981, Duffy et al., 1996, Arora et al., 1987, Konopka et al., 1991, Bolshakov and Zhimulev, 1987, Rodrigues et al., 1991, Anand and Chandra, 1994, Eeken and Sobels, 1990, Craymer and Roy, 1980)
Breakpoints	10E1-10E2;11A6-11A9 (Bolshakov and Zhimulev, 1987) 10E1;11A7 (Craymer and Roy, 1980, Arora et al., 1987, Eeken and Sobels, 1990, Rodrigues et al., 1991) 10E1;11A7-11A8 (Konopka et al., 1991, Anand and Chandra, 1994, Pauli et al., 1995, Duffy et al., 1996) 10E2;11A7 (Mason et al., 1981)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	Rst(1)JH << bk1 << l(1)10Fk << l(1)10Ea << bk2 << gs(1)N41
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Jackson, 1990)
Comments on Cytology
	Deletion of 22/24 bands. (Eeken and Sobels, 1990) All limits from polytene analysis (FBrf0034402)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	cac (Kulkarni and Hall, 1987) dy (DiBartolomeis et al., 2002, Roch et al., 2003, Craymer and Roy, 1980, Newby et al., 1991, Konopka et al., 1991) Gtd (Rodrigues et al., 1991) gustB (Arora et al., 1987, Rodrigues et al., 1991) gustC (Rodrigues et al., 1991) gustD (Rodrigues et al., 1991) m (DiBartolomeis et al., 2002, Roch et al., 2003) wisp (Brent et al., 2000, Tadros et al., 2003)
Molecular Data
Completely deleted	Ten-a (Rakovitsky et al., 2007) tsg (Rakovitsky et al., 2007)
Genes NOT Deleted / Disrupted
Complementation Data
	fw (Craymer and Roy, 1980) gs(1)N41 (Hatanaka and Okada, 1991) mei-41 (Mason et al., 1981) Met (Wilson and Fabian, 1986) mus101 (Mason et al., 1981) mus109 (Mason et al., 1981) roX2 (Franke and Baker, 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(1)KA6/Df(1)m259-4 heterozygotes are viable. (Rodrigues et al., 1991) Heterozygotes with Df(1)m259-4 survive and have an extreme m phenotype with flimsy wings. (Craymer and Roy, 1980)
NOT in combination with other aberrations	Df(1)KA6 hemizygous embryos exhibit head and thorax defects similar to tsg loss of function mutants. With a very low penetrance, Df(1)KA6 hemizygous embryos show subtle defects in segmentation, including partial fusion of denticle band pairs in the register seen for Ten-m mutants. Flies with transheterozygous combinations of Df(1)KA6/+ and Ten-m[628]/+ display eye roughness. Consistent features include ommatidial order defects, ommatidial fusions, eye sensory bristle loss, and occasional supernumerary sensory bristles. (Rakovitsky et al., 2007) Hemizygous late embryonic lethal. (Franke and Baker, 1999) Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 50% of run³ heterozygotes. Maternal heterozygosity for Df(1)KA6 greatly increases the frequency of segmentation defects in embryos heterozygous for eve, run and Kr. (Duffy et al., 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) No significant change in female lethality when in combination with Sxl^f1. (Anand and Chandra, 1994) Heterozygous females exhibit reduced viability and fertility. (Eeken and Sobels, 1990)
Stocks ( 2 )
Bloomington	960 Df(1)KA6/FM7c
Kyoto	106143 Df(1)KA6/FM7c
Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(1)KA6 (Rakovitsky et al., 2007, Kinel-Tahan et al., 2007) DfKA6 (Mason et al., 1981) KA-6 (Sanchez et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 29 )

Generate a list of	All references relating to this aberration ( 29 )

List References by type	Research paper ( 26 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...