A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(1)N-54l9

General Information
SymbolDmel\Df(1)N-54l9SpeciesD. melanogaster
NameDeficiency (1) NotchFlyBase IDFBab0000564
Feature typechromosomal_deletion
Also Known AsN54l9, N5419, Df(1)N54l9, N54/9, Notch54l9, Df(1)N5419
Computed Breakpoints include 3C6;3C11
Deleted segment3C6--3C11
Map ( GBrowse ) GBrowse View Help Untitled Document

Error

No matching regions found.

Sequence coordinates
X:3,134,959..3,136,127 [-] (Df(1)N-54l9:bk2)
(Furia et al., 1993)
Member of large scale dataset(s)
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Description
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
(Lefevre and Green, 1972)
Class of aberration (relative to progenitor)
chromosomal_deletion
(McGinnis et al., 1980, Lefevre and Green, 1972, Saumweber et al., 1990, Furia et al., 1993, Lefevre, 1971)
Breakpoints
3C5-3C6;3C11-3C12
(Saumweber et al., 1990)
3C5;3C10
(Furia et al., 1993)
3C6;3C10
(Lefevre and Green, 1972, McGinnis et al., 1980)
3C6;3C11
(Lefevre, 1971)
Causes alleles
dnc54l9
(Qiu and Davis, 1993)
Carries alleles
Transposon Insertions
Formalized genetic data rst << bk1 << vt << ng2 << bk2 << ng1
Genetic mapping information
Comments
Breakpoint(s) molecularly mapped
(McGinnis and Beckendorf, 1983, Chen et al., 1986, Levis et al., 1982, Perlman, 1983)
Lacks Sgs-4 sequences (McGinnis et al., 1980).
 
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0023492) Right limit of break 1 from inclusion of vt (FBrf0023492) Left limit of break 2 from inclusion of ng2 (FBrf0058951) Right limit of break 2 from polytene analysis (FBrf0063630)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
dnc
(Qiu and Davis, 1993)
N
(Pitsouli and Delidakis, 2005, Lefevre and Green, 1972, Kramers et al., 1983, Bargiello and Young, 1984, Kramers et al., 1991, Mohler, 1956, Hing et al., 1994, Maitra et al., 2006, Tien et al., 2008)
ng2
(Furia et al., 1993)
vt
(Lefevre and Green, 1972)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Actn
(Kramers et al., 1991)
crm
(Kramers et al., 1991)
crn
(Kramers et al., 1991)
dm
(Mohler, 1956, Kramers et al., 1983, Kramers et al., 1991)
dwg
(Kramers et al., 1991)
ec
(Mohler, 1956)
egh
(Kramers et al., 1991)
gt
(Kramers et al., 1991)
kz
(Kramers et al., 1991)
l(1)2Dj
(Kramers et al., 1991)
l(1)2Dk
(Kramers et al., 1991)
l(1)2Dl
(Kramers et al., 1991)
l(1)2Dm
(Kramers et al., 1991)
l(1)2Ea
(Kramers et al., 1991)
l(1)2Ec
(Kramers et al., 1991)
l(1)2Ed
(Kramers et al., 1991)
l(1)2Fb
(Kramers et al., 1991)
l(1)2Fc
(Kramers et al., 1991)
l(1)2Fd
(Kramers et al., 1991)
l(1)2Ff
(Kramers et al., 1991)
l(1)2Fg
(Kramers et al., 1991)
l(1)3-64
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3ABa
(Kramers et al., 1991)
l(1)3ABb
(Kramers et al., 1991)
l(1)3Ah
(Kramers et al., 1991)
l(1)3Aj
(Kramers et al., 1991)
l(1)3Ak
(Kramers et al., 1991)
l(1)3Al
(Kramers et al., 1991)
l(1)3Am
(Kramers et al., 1991)
l(1)3An
(Kramers et al., 1991)
l(1)3Ao
(Kramers et al., 1991)
l(1)3Ap
(Kramers et al., 1991)
l(1)3Aq
(Kramers et al., 1991)
l(1)3Bb
(Kramers et al., 1991)
l(1)3Bc
(Kramers et al., 1991)
l(1)3Bd
(Kramers et al., 1991)
l(1)3Bf
(Kramers et al., 1991)
l(1)3Bg
(Kramers et al., 1991)
l(1)3Da
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Eb
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Ed
(Kramers et al., 1983, Kramers et al., 1991)
l(1)7-103
(Kramers et al., 1983, Kramers et al., 1991)
l(1)EA65
(Kramers et al., 1983, Kramers et al., 1991)
l(1)ESHS14
(Kramers et al., 1991)
mit(1)15
(Kramers et al., 1991)
ng1
(Furia et al., 1993)
Pgd
(Kramers et al., 1991)
phl
(Kramers et al., 1991)
pn
(Kramers et al., 1991)
rst
(Kramers et al., 1983, Kramers et al., 1991, Mohler, 1956)
sgg
(Kramers et al., 1991)
Sgs4
(McGinnis et al., 1980, McNabb and Beckendorf, 1986)
tko
(Kramers et al., 1991)
trol
(Kramers et al., 1991)
w
(Kramers et al., 1983, Kramers et al., 1991, Mohler, 1956)
wapl
(Kramers et al., 1991)
wds
(Kramers et al., 1991)
z
(Kramers et al., 1991)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Lethal in male double hemizygous combination with Df(1)w67c3.
(Lefevre and Green, 1972)
Viable in combination with Df(1)w67k30, producing flies which have a strong vt phenotype, but are not rough eyed.
(Lefevre, 1971)
Df(1)N-54l9/Df(1)w67k30 viable Df(1)N-54l9/Df(1)w67k30 vt phenotype
 
NOT in combination with other aberrations
Df(1)N-54l9/+ females display a relatively weak notch-wing phenotype, characterised by wing vein thickening (preferentially L3 and L5) and by delta formation at the contact between wing veins and the wing edge. One or more notches is present in 75% of Df(1)N-54l9/+ wings.
(Peralta et al., 2009)
55% of Df(1)N-54l9/+ flies have a notched wing phenotype.
(Kugler and Nagel, 2007)
The number of cap cells and germline stem cells in the ovaries of 2 day old heterozygous females is significantly reduced compared to wild type.
(Song et al., 2007)
Df(1)N-54l9 heterozygotes exhibit notches at the wing margin. Df(1)N-54l9 Mer4; exe1 triple transheterozygous mutants suppress the Df(1)N-54l9 heterozygous wing notch phenotype.
(Maitra et al., 2006)
Clones of Df(1)N-54l9 mutant cells in the eye disc show a cell-autonomous block of mitosis and DNA synthesis in the position of the second mitotic wave (SMW). However, a small number of mutant cells do incorporate BrdU (a marker of S phase) in the most posterior regions of clones, significantly behind the SMW. Cell proliferation ahead of the morphogenetic furrow is not detectably impaired in Df(1)N-54l9 mutant cells.
(Baonza and Freeman, 2005)
Df(1)N-54l9 third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 44.5% of SOP positions scored. Approximately 26% of SOP positions display between four and eight ectopic SOPs, while approximately 26% exhibit between one and four SOPs, with only 3.5% exhibiting one SOP, as in wild-type. Df(1)N-54l9 third instar nota clones exhibit a partially penetrant growth defect.
(Pitsouli and Delidakis, 2005)
Large Df(1)N-54l9 mutant clones in the eye disc (generated in a Minute/+ background) have very few or no neurons. Small clones (generated in a wild-type background) have extra neuronal cells. Basally located nuclei are found along the posterior margin of small clones.
(Zhang et al., 2005)
Neuronal development is impaired in when Df(1)N-54l9 is expressed in clones within the eye-antennal disc.
(Kenyon et al., 2003)
Visceral mesoderm is reduced in mutant embryos.
(Duan et al., 2001)
Non-muscle defects are seen in mutants.
(Strunkelnberg et al., 2001)
Heterozygous Df(1)N-54l9 flies exhibit a weakly-penetrant wing nicking phenotype.
(Helms et al., 1999)
Notches at the distal wing margin.
(Fostier et al., 1998)
No R8 cells or photoreceptor neurons develop in a N clone on the eye-disc.
(Baker and Yu, 1997)
Notching of the distal wing margin can be suppressed by osa308.
(Treisman et al., 1997)
Abnormal epidermal and muscle development. Presence of Scer\GAL4twi.PBa can normalise some but no all aspects of myogenesis in Df(1)N-54l9 mutants.
(Baker and Schubiger, 1996)
No effect on the faf eye phenotype.
(Huang and Fischer-Vize, 1996)
Suppression of the lethal SerBd-3 Ser+r83k combination, escapers exhibit phenotypically normal eyes and legs but lack halteres and had wing blades one half normal size.
(Gu et al., 1995)
Dominant enhancer of the scaMSKF mutant phenotype.
(Hu et al., 1995)
A few flies of the genotype Df(1)N-54l9,dxENU/+,dxENU;Su(dx)1/+ escape the lethality of their dead Df(1)N-54l9,dxENU/+,dxENU siblings. However they have the same, small, rough eye defect as their dead siblings.
(Busseau et al., 1994)
Heterozygotes show lethal interaction with gain of function Su(H) alleles.
(Fortini and Artavanis-Tsakonas, 1994)
The wing-notching phenotype of Df(1)N-54l9 heterozygotes is more severe in flies which also carry one or two copies of EgfrE3 or EgfrE1.
(Baker and Rubin, 1992)
cosP{479BE} construct rescues the embryonic lethality and therefore the neurogenic phenotype of homozygotes and the dominant wing notching phenotype of heterozygous females.
(Ramos et al., 1989)
Puff formation at 3C11 during intermoult period.
(McNabb and Beckendorf, 1986)
Homozygous males are lethal.
(Lefevre and Green, 1972)
Weak Notch. Deltas of long veins reliable in classification when wing tips not notched.
 
hide Stocks ( 1 )
Bloomington
6894
Df(1)N-54l9, y1/C(1)DX, y1 w1 f1; Dp(1;2)51b/+
hide Notes on Origin
Discoverer
Mohler, 9th Dec. 1954.
 
hide Balancer / Genotype Variants of the Aberration
hide Separable Components
hide Other Comments
hide Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym
Df(1)N-54l9
 
Df(1)N-5419
(Weber et al., 2012)
Df(1)N54l9
(Strunkelnberg et al., 2001, Nighorn et al., 1994, Furia et al., 1993, Hing et al., 1994, Saumweber et al., 1990, Kramers et al., 1983, Welshons and Welshons, 1986, Lefevre and Green, 1972, McGinnis et al., 1980, Qiu and Davis, 1993, McNabb and Beckendorf, 1986, Peralta et al., 2009)
Df(1)N5419
(Weavers et al., 2009, Kugler and Nagel, 2010)
DfN54l9
(Kramers et al., 1991)
N54/9
(Kenyon et al., 2003, Lee et al., 2000, Baonza and Freeman, 2001, Baonza and Freeman, 2005)
N54l9
(Pitsouli and Delidakis, 2005, Baron et al., 2000, Ye and Fortini, 1999, Cornell et al., 1999, Ligoxygakis et al., 1999, Lefevre, 1971, Hu et al., 1995, Busseau et al., 1994, Fostier et al., 1998, Baker and Yu, 1997, Huang and Fischer-Vize, 1996, Cadigan and Nusse, 1996, Sun and Artavanis-Tsakonas, 1996, Baker and Schubiger, 1996, Gu et al., 1995, Maitra et al., 2006, Song et al., 2007, Fuwa et al., 2006, Leonardi et al., 2011)
N5419
(Tien et al., 2008, Mueller et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Johannes and Preiss, 2002, Duan et al., 2001, Morel and Schweisguth, 2000, Helms et al., 1999, Treisman et al., 1997, Schmid et al., 1996, Baker and Rubin, 1992, Kugler and Nagel, 2007, Kankel et al., 2007, Beam and Moberg, 2010, Cho and Fischer, 2011, Kugler and Nagel, 2010)
Notch54l9
(Sasaki et al., 2007, Zhang et al., 2005)
Name Synonym
Deficiency (1) Notch
 
Secondary FlyBase IDs
  • FBab0023986
  • FBal0038924
hide References ( 68 )
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hide Recent research papers ( 3 )
Weber et al., 2012, Genetics 191(1): 145--162
Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210]
Cho and Fischer, 2011, Development 138(7): 1349--1359
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. [FBrf0213208]
Leonardi et al., 2011, Development 138(16): 3569--3578
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. [FBrf0214548]
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