|Name||Deficiency (1) Notch||FlyBase ID||FBab0000579|
|Also Known As||Df(1)N8, Df(1)N8, N8, N8|
|Computed Breakpoints include||3C1;3D6|
|Member of large scale dataset(s)|
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|Nature of the Aberration|
|Class of aberration (relative to progenitor)|
|Formalized genetic data||l(1)3Bf << bk1 << crm << l(1)EA65 << bk2 << l(1)3Eb|
|Genetic mapping information|
|Comments on Cytology|
Deletion of 17/19 bands.
|Gene Deletion & Duplication Data|
|Genes Deleted / Disrupted|
|Completely deleted / disrupted|
|Genes NOT Deleted / Disrupted|
|Genes NOT Duplicated|
|In combination with other aberrations|
|NOT in combination with other aberrations|
Heterozygotes show loss of wing margin and wing vein thickening.
Flies bearing Df(1)N-8 are generally smaller than wild-type flies and have a transient, slightly brown, eye phenotype shortly after eclosion.
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
Heterozygotes of Df(1)N-8 or N55e11 with Abl1,NrtM54 or In(3L)std11 show defects in eye development leading to rough eyes with high penetrance.
Single cells from Df(1)N-8 embryos transplanted into the ventral neurogenic region of wild-type host embryos can give rise to both neural and epidermal cells.
Deficient embryos show an uninterpretable mutant midgut phenotype.
Homozygous embryos are very abnormal compared to wild-type. Midgut primordia do not fuse, and Malpighian tubules branch.
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells. Extra precursor cells are recruited beyond the normal time window for neurogenesis in the PNS.
Heterozygous females exhibit reduced viability and fertility.
|Stocks ( 2 )|
|Notes on Origin|
Mohr, 7 Oct. 1918.
|Balancer / Genotype Variants of the Aberration|
|Synonyms & Secondary IDs ( 13 )|
(Sturtevant, 1955, Quan et al., 2004, Ruiz-Gomez et al., 2000, Pastink et al., 1987, Giniger, 1998, Rottgen et al., 1998, Eeken and Sobels, 1990, Cohen et al., 1997, Bodmer et al., 1993, Matsuzaki and Saigo, 1996, Gateff and Mechler, 1989, Dambly-Chaudiere and Leyns, 1992, Kramers et al., 1983, Wieschaus et al., 1984, Godt et al., 1991, Leonardi et al., 2011)
Deficiency (1) Notch
|Secondary FlyBase IDs|
|References ( 81 )|
|Generate a list of|
|List References by type|
|Recent research papers ( 2 )|
|Recent reviews (0)|
|All reviews listed in FlyBase were published before 2011|