A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(1)N-8

General Information
SymbolDmel\Df(1)N-8SpeciesD. melanogaster
NameDeficiency (1) NotchFlyBase IDFBab0000579
Feature typechromosomal_deletion
Also Known AsDf(1)N8, Df(1)N8, N8, N8
Computed Breakpoints include 3C1;3D6
Deleted segment3C1--3D6
Sequence coordinates
Member of large scale dataset(s)
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Description
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FB2013_03
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
(Eeken and Sobels, 1990, Slizynska, 1938)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Wieschaus et al., 1984, Pauli et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Vervoort et al., 1997, Eeken and Sobels, 1990, Slizynska, 1938)
Breakpoints
3B4-3C1;3D6-3E1
(Wieschaus et al., 1984)
3C1-3C2;3D5-3D6
(Slizynska, 1938)
3C1-3C2;3E2-3E3
(Eeken and Sobels, 1990)
3C2-3C3;3E3-3E4
(Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Vervoort et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data l(1)3Bf << bk1 << crm << l(1)EA65 << bk2 << l(1)3Eb
Genetic mapping information
Comments
hide Comments on Cytology
Deletion of 17/19 bands.
(Eeken and Sobels, 1990)
Ref: FBrf0034104
(Wieschaus et al., 1984)
Left limit of break 1 from polytene analysis (FBrf0004288) Right limit of break 1 from inclusion of crm (FBrf0038033) Left limit of break 2 from polytene analysis (FBrf0040178) Right limit of break 2 from polytene analysis (FBrf0004288)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
crm
(Thierry-Mieg, 1982, Lin and Wolfner, 1989)
dm
(Johnston et al., 1999, Kramers et al., 1983, Kramers et al., 1991, Eeken et al., 1985)
kirre
(Ruiz-Gomez et al., 2000)
l(1)3Da
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Db
(Vervoort et al., 1997)
l(1)EA65
(Kramers et al., 1983, Kramers et al., 1991)
l(1)ESHS18
(Eeken et al., 1985)
l(1)ESHS19
(Eeken et al., 1985)
N
(Rottgen et al., 1998, Ruiz-Gomez et al., 2000, Dietrich et al., 2005, Glass, 1933, Mackensen, 1935, Thierry-Mieg, 1982, Kramers et al., 1983, Slizynska, 1938, Eeken et al., 1985, Lin and Wolfner, 1989, Kramers et al., 1991, Harbecke and Lengyel, 1995, Cohen et al., 1997)
rst
(Ruiz-Gomez et al., 2000, Thierry-Mieg, 1982, Kramers et al., 1983, Slizynska, 1938, Lin and Wolfner, 1989, Kramers et al., 1991)
vt
(Ruiz-Gomez et al., 2000, Thierry-Mieg, 1982, Lin and Wolfner, 1989)
w
(Lloyd et al., 2002, Mackensen, 1935, Thierry-Mieg, 1982, Kramers et al., 1983, Slizynska, 1938, Eeken et al., 1985, Lin and Wolfner, 1989, Gailey et al., 1991, Kramers et al., 1991)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Actn
(Kramers et al., 1991)
cho
(Sturtevant, 1955)
crm
(Kramers et al., 1983)
crn
(Kramers et al., 1991)
dwg
(Kramers et al., 1983, Lin and Wolfner, 1989, Kramers et al., 1991)
ec
(Mackensen, 1935)
egh
(Lin and Wolfner, 1989, Kramers et al., 1991)
fs(1)Ya
(Lin and Wolfner, 1989)
fs(1)Yb
(Lin and Wolfner, 1989)
gt
(Lin and Wolfner, 1989, Kramers et al., 1991)
Klp3A
(Page and Hawley, 2005)
kz
(Kramers et al., 1991)
l(1)2Dj
(Kramers et al., 1991)
l(1)2Dk
(Kramers et al., 1991)
l(1)2Dl
(Kramers et al., 1991)
l(1)2Dm
(Kramers et al., 1991)
l(1)2Ea
(Kramers et al., 1991)
l(1)2Ec
(Kramers et al., 1991)
l(1)2Ed
(Kramers et al., 1991)
l(1)2Fb
(Kramers et al., 1991)
l(1)2Fc
(Kramers et al., 1991)
l(1)2Fd
(Eeken et al., 1985, Kramers et al., 1991)
l(1)2Ff
(Kramers et al., 1991)
l(1)2Fg
(Kramers et al., 1991)
l(1)3-64
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3ABa
(Kramers et al., 1991)
l(1)3ABb
(Kramers et al., 1991)
l(1)3Ag
(Lin and Wolfner, 1989)
l(1)3Ah
(Eeken et al., 1985, Lin and Wolfner, 1989, Kramers et al., 1991)
l(1)3Aj
(Kramers et al., 1991)
l(1)3Ak
(Kramers et al., 1991)
l(1)3Al
(Kramers et al., 1991)
l(1)3Am
(Kramers et al., 1991)
l(1)3An
(Kramers et al., 1991)
l(1)3Ao
(Kramers et al., 1991)
l(1)3Ap
(Kramers et al., 1991)
l(1)3Aq
(Kramers et al., 1991)
l(1)3Bb
(Kramers et al., 1983, Lin and Wolfner, 1989, Kramers et al., 1991)
l(1)3Bc
(Kramers et al., 1983, Lin and Wolfner, 1989, Kramers et al., 1991)
l(1)3Bd
(Kramers et al., 1983, Lin and Wolfner, 1989, Kramers et al., 1991)
l(1)3Bf
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Bg
(Kramers et al., 1991)
l(1)3Eb
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Ed
(Kramers et al., 1983, Kramers et al., 1991)
l(1)7-103
(Kramers et al., 1983, Kramers et al., 1991)
l(1)ESHS6
(Eeken et al., 1985)
l(1)ESHS7
(Eeken et al., 1985)
l(1)ESHS8
(Eeken et al., 1985)
l(1)ESHS9
(Eeken et al., 1985)
l(1)ESHS10
(Eeken et al., 1985)
l(1)ESHS11
(Eeken et al., 1985)
l(1)ESHS12
(Eeken et al., 1985)
l(1)ESHS13
(Eeken et al., 1985)
l(1)ESHS14
(Eeken et al., 1985, Kramers et al., 1991)
l(1)ESHS15
(Eeken et al., 1985)
l(1)ESHS16
(Eeken et al., 1985)
l(1)ESHS17
(Eeken et al., 1985)
l(1)ESHS20
(Eeken et al., 1985)
l(1)ESHS21
(Eeken et al., 1985)
l(1)ESHS22
(Eeken et al., 1985)
l(1)ESHS23
(Eeken et al., 1985)
mit(1)15
(Lin and Wolfner, 1989, Kramers et al., 1991)
par
(Thierry-Mieg, 1982)
per
(Lin and Wolfner, 1989, Dushay et al., 1990, Gailey et al., 1991)
Pgd
(Kramers et al., 1991)
phl
(Kramers et al., 1991)
pn
(Mackensen, 1935, Kramers et al., 1991)
rey
(Sturtevant, 1948)
sgg
(Lin and Wolfner, 1989, Kramers et al., 1991)
tko
(Lin and Wolfner, 1989, Kramers et al., 1991)
trol
(Lin and Wolfner, 1989, Kramers et al., 1991, Eeken et al., 1985)
w
(Ruiz-Gomez et al., 2000)
wapl
(Kramers et al., 1991)
wds
(Lin and Wolfner, 1989, Kramers et al., 1991)
z
(Lin and Wolfner, 1989, Kramers et al., 1991)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Does not complement Df(1)w67k30.
(Ruiz-Gomez et al., 2000)
Covered by Dp(1;2)w-ec.
(Lefevre, 1968)
NOT in combination with other aberrations
Df(1)N-8 heterozygotes exhibit a dominant wing notching phenotype.
(Herz et al., 2010)
Heterozygotes show loss of wing margin and wing vein thickening.
(Herranz et al., 2006)
Flies bearing Df(1)N-8 are generally smaller than wild-type flies and have a transient, slightly brown, eye phenotype shortly after eclosion.
(Lloyd et al., 2002)
Df(1)N-8 flies exhibit a weak loss of wing margin.
(Stewart et al., 2001)
Shows dominant wing nicking which is enhanced by PsnW11 and PsnW6.
(Guo et al., 1999)
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
(Coyne et al., 1998)
Heterozygotes of Df(1)N-8 or N55e11 with Abl1,NrtM54 or In(3L)std11 show defects in eye development leading to rough eyes with high penetrance.
(Giniger, 1998)
No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.
(Halsell and Kiehart, 1998)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
Single cells from Df(1)N-8 embryos transplanted into the ventral neurogenic region of wild-type host embryos can give rise to both neural and epidermal cells.
(Stuttem and Campos-Ortega, 1997)
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
(Duffy et al., 1996)
Deficient embryos show an uninterpretable mutant midgut phenotype.
(Bilder and Scott, 1995)
Homozygous embryos are very abnormal compared to wild-type. Midgut primordia do not fuse, and Malpighian tubules branch.
(Harbecke and Lengyel, 1995)
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Reveals antimorphic alleles of P{en1}wgen11.
(Couso and Martinez Arias, 1994)
Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells. Extra precursor cells are recruited beyond the normal time window for neurogenesis in the PNS.
(Bodmer et al., 1993)
Heterozygous females exhibit reduced viability and fertility.
(Eeken and Sobels, 1990)
hide Stocks ( 2 )
Bloomington
729
Df(1)N-8/FM7c
Kyoto
108911
Df(1)N-8/FM7c
hide Notes on Origin
Discoverer
Mohr, 7 Oct. 1918.
 
hide Balancer / Genotype Variants of the Aberration
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hide Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym
DelNotch8
(Mackensen, 1935)
Df(1)N
(Herranz et al., 2006)
Df(1)N8
(Lloyd et al., 2002, Stewart et al., 2001, Johnston et al., 1999, Gailey et al., 1991, Vervoort et al., 1997, Dushay et al., 1990, Lin and Wolfner, 1989, Thierry-Mieg, 1982, Rhyu et al., 1994, Reuter et al., 1993)
Df(1)N-8
(Crest et al., 2007, Ozdowski et al., 2009)
Df(1)N8
(Sturtevant, 1955, Quan et al., 2004, Ruiz-Gomez et al., 2000, Pastink et al., 1987, Giniger, 1998, Rottgen et al., 1998, Eeken and Sobels, 1990, Cohen et al., 1997, Bodmer et al., 1993, Matsuzaki and Saigo, 1996, Gateff and Mechler, 1989, Dambly-Chaudiere and Leyns, 1992, Kramers et al., 1983, Wieschaus et al., 1984, Godt et al., 1991, Leonardi et al., 2011)
Df(1)Notch-8
(Herranz et al., 2006)
DfN8
(Kramers et al., 1991)
N8
(Glass, 1933, Sanchez et al., 1994)
N-8 Mohr
(Slizynska, 1938)
N8
(Shellenbarger and Mohler, 1975, Sturtevant, 1948, Stuttem and Campos-Ortega, 1997, Gateff, 1978, Couso and Martinez Arias, 1994, Herz et al., 2010, Tsubota et al., 2011)
NN8
(Edgar et al., 1994)
Notch8
(Wu and Rao, 1999)
Name Synonym
Deficiency (1) Notch
 
Secondary FlyBase IDs
  • FBal0029936
  • FBal0058507
hide References ( 81 )
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hide Recent research papers ( 2 )
Leonardi et al., 2011, Development 138(16): 3569--3578
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. [FBrf0214548]
Tsubota et al., 2011, Fly 5(4): 275--284
Interactions between enhancer of rudimentary and Notch and deltex reveal a regulatory function of enhancer of rudimentary in the Notch signaling pathway in Drosophila melanogaster. [FBrf0217950]
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