Aberration Dmel\Df(1)N19

General Information
Symbol	Dmel\Df(1)N19	Species	D. melanogaster
Name		FlyBase ID	FBab0000596
Feature type	chromosomal_deletion
Also Known As	N19

Computed Breakpoints include	17A1;18A2
Deleted segment	17A1--18A2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Eberl et al., 1992)
Class of aberration (relative to progenitor)	chromosomal_deletion (Ferrus et al., 1990, Fradkin et al., 1995, Deak et al., 1982, Pauli et al., 1995, Duffy et al., 1996, Cook et al., 1997, Harbecke and Lengyel, 1995, Landecker et al., 1994, Anand and Chandra, 1994, Craymer and Roy, 1980)
Breakpoints	16F;19B (Eisenberg et al., 1992) 17A1;18A2 (Landecker et al., 1994, Anand and Chandra, 1994, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Cook et al., 1997) 17A3-17A6;17F2-18A3 (Fradkin et al., 1995) 17A7-17A8;18A6-18A7 (Ferrus et al., 1990) 17A;18A2 (Craymer and Roy, 1980, Deak et al., 1982)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	wupA << bk1 << fliH << bk2
Genetic mapping information
Comments
Comments on Cytology
	Ref: Craymer and Roy, 1980, D. I. S. 55: 200--204. (Fradkin et al., 1995) First chromosome breakpoint is 20kb distal to the first chromosome breakpoint of T(1;Y)B137. (Ferrus et al., 1990) Limits of break 1 from polytene analysis (FBrf0076124) Limits of break 2 from polytene analysis (FBrf0034402)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ado (Eberl et al., 1992) Bx (Deak et al., 1982) fcl (Eberl et al., 1992) fliH (Shoresh et al., 1998) fu (Craymer and Roy, 1980, Mariol et al., 1987) juv (Eberl et al., 1992) lar (Eberl et al., 1992) os (Eberl et al., 1992, Harbecke and Lengyel, 1995) phm (Tearle and Nusslein-Volhard, 1987, Eberl et al., 1992, Harbecke and Lengyel, 1995) plp (Eberl et al., 1992) psh (Ligoxygakis et al., 2002) Wnt5 (Eisenberg et al., 1992, Fradkin et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	os (Craymer and Roy, 1980) wupA (Homyk and Emerson, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Df(1)N19 weakly decreases transmission. (Cook et al., 1997) Df(1)svr/Df(1)N19 and Df(1)N71/Df(1)N19 double heterozygous females have reduced viability; only 30% and 8% respectively survive compared to control flies. Viability is recovered if the Df(1)svr/Df(1)N19 or Df(1)N71/Df(1)N19 females also carry Sxl^M1. (Sanchez et al., 1994)
NOT in combination with other aberrations	29% of Df(1)N19 homozygous embryos show defects in germ-band extension. (Bertet et al., 2009) Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos are very abnormal compared to wild-type. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) More than six-fold reduction in sex ratio and significant levels of female lethality is observed when in combination with Sxl^f1. Female lethality is also reduced when in combination with da¹ but restored when in combination with emc^ML. (Anand and Chandra, 1994) 'Sloppy' ventral cord. (Smith et al., 1993)
Stocks ( 2 )
Bloomington	970 Df(1)N19/FM6
Kyoto	106694 Df(1)N19/FM6
Notes on Origin
Discoverer	Lefevre.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df970 (Mertens et al., 2005) Df(1)970 (Ligoxygakis et al., 2002) Df(1)N19 (Crest et al., 2007, Becalska and Gavis, 2010, Wang et al., 2008, Zenvirt et al., 2008) Df(970) (Bertet et al., 2009) N19 (Sanchez et al., 1994, Mariol et al., 1987)
Name Synonym
Secondary FlyBase IDs

References ( 45 )

Generate a list of	All references relating to this aberration ( 45 )

List References by type	Research paper ( 41 ) Supplementary material ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...