Aberration Dmel\Df(1)Pgd35

General Information
Symbol	Dmel\Df(1)Pgd35	Species	D. melanogaster
Name	Deficiency (1) Phosphogluconate dehydrogenase	FlyBase ID	FBab0000606
Feature type	chromosomal_deletion
Also Known As	Df(1)Pgd³⁵

Computed Breakpoints include	2C2-2C4;2E2-2E3
Deleted segment	2C2--2E3
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Watson et al., 1991, Pauli et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Anand and Chandra, 1994, Craymer and Roy, 1980)
Breakpoints	2C2-2C4;2E2-2F1 (Pauli et al., 1995, Harbecke and Lengyel, 1995) 2C2-2C4;2E2-2F5 (Anand and Chandra, 1994) 2C2-2C4;2F5 (Duffy et al., 1996) 2D3;2E2-2F5 (Watson et al., 1991) 2D3;2F5 (Craymer and Roy, 1980)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << pn << bk2 << l(1)2Ea
Genetic mapping information
Comments
Comments on Cytology
	Ref: FBrf0034402 (Watson et al., 1991) Limits of break 1 from polytene analysis (FBrf0079851) Left limit of break 2 from polytene analysis (FBrf0053739) Right limit of break 2 from non-inclusion of l(1)2Ea (FBrf0040957)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	pn (Perrimon et al., 1984)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	crn (Perrimon et al., 1984) fs(1)K10 (Perrimon et al., 1984) gt (Perrimon et al., 1984) kz (Perrimon et al., 1984) l(1)2Ea (Perrimon et al., 1984) l(1)2Fb (Perrimon et al., 1984) l(1)2Fc (Perrimon et al., 1984) l(1)2Fd (Perrimon et al., 1984) pcx (Perrimon et al., 1984) per (Dushay et al., 1990) phl (Perrimon et al., 1984) Rbcn-3B (Yan et al., 2009)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(1)Pgd35/Df(1)X12 fertile. Df(1)Pgd35/Df(1)X12 viable. Df(1)Pgd35/Df(1)X12 viable Df(1)Pgd35/Df(1)X12 fertile
NOT in combination with other aberrations	Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) No significant change in female lethality when in combination with Sxl^f1. (Anand and Chandra, 1994) Hemizygous embryos were examined with polarised light microscopy and antibody staining and found to have wild type muscle pattern and contraction. (Drysdale et al., 1993)
Stocks ( 2 )
Bloomington	2986 Df(1)Pgd35, pn¹/FM0
Kyoto	107508 Df(1)Pgd35, pn^1?/FM7d
Availability	Stated to be lost. (Craymer and Roy, 1980)
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(1)Pgd35 (Wang et al., 2006, Yan et al., 2009) Df(1)Pgd³⁵ (Craymer and Roy, 1980, Dushay et al., 1990, Perrimon et al., 1984, Watson et al., 1991)
Name Synonym	Deficiency (1) Phosphogluconate dehydrogenase
Secondary FlyBase IDs

References ( 17 )
Research paper	Yan et al., 2009, Dev. Cell 17(3): 387--402 The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. [FBrf0208777] Wang et al., 2006, Development 133(7): 1231--1240 Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. [FBrf0190330] Takano-Shimizu, 2000, Genetics 156(1): 269--282 Genetic screens for factors involved in the notum bristle loss of interspecific hybrids between Drosophila melanogaster and D. simulans. [FBrf0130105] Nicholls and Gelbart, 1998, Genetics 149(1): 203--215 Identification of chromosomal regions involved in decapentaplegic function in Drosophila. [FBrf0102843] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Harbecke and Lengyel, 1995, Rouxs Arch. Dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Anand and Chandra, 1994, J. Genet. 73(2-3): 81--90 Synergistic interaction between particular X-chromosome deletions and Sex-lethal causes female lethality in Drosophila melanogaster. [FBrf0079851] Drysdale et al., 1993, Rouxs Arch. Dev. Biol. 202(5): 276--295 Genes required for embryonic muscle development in Drosophila melanogaster: A survey of the X chromosome. [FBrf0059320] Smith et al., 1993, Genetics 135(3): 817--829 Identification of genomic regions required for DNA replication during Drosophila embryogenesis. [FBrf0065574] Watson et al., 1991, Dev. Genet. 12: 173--187 Lethal(1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster. [FBrf0053739] Dushay et al., 1990, Genetics 125: 557--578 Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. [FBrf0051955] Perrimon et al., 1984, Genetics 108: 559--572 Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in 'developmentally important' genes. [FBrf0040957] Craymer and Roy, 1980, D. I. S. 55: 200--204 Report of New Mutants -- Drosophila melanogaster. [FBrf0034402]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]