FlyBase Aberration Report: Dmel\Df(1)os1A2

General Information

Symbol

Df(1)os1A2

Species

D. melanogaster

Name

FlyBase ID

FBab0000868

Feature type

chromosomal_deletion

Also Known As

Df(1)os1A, Df(1)os^1A, upd^os1A, os1A

Computed Breakpoints include

17A1-17A2;17A6

Features within 17A1--17A6

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Sanchez et al., 1994, Ferrus et al., 1990)

Breakpoints

17A1-17A4;17A9-17A10

(Sanchez et al., 1994, Ferrus et al., 1990)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

wupA << bk1 << l(1)17Aa << l(1)17Ab << bk2 << CrebB-17A

Genetic mapping information

Comments

Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0051942) Right limit of break 1 from inclusion of os (FBrf0056238) Left limit of break 2 from inclusion of l(1)17Ab (FBrf0051942) Right limit of break 2 from non-inclusion of CrebB-17A (citation unavailable)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

l(1)17Ab

(Ferrus et al., 1990)

upd1

(Eberl et al., 1992)

Partially deleted / disrupted

Molecular Data

Completely deleted

upd1

(Hombria et al., 2005, Agaisse et al., 2003)

upd2

(Hombria et al., 2005)

upd3

(Hombria et al., 2005)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Df(1)os1A2 is wild-type for sex-determination function (the "sisC" function of os) despite lacking the os gene as it is associated with a closely linked, maternal-effect suppressor.

(Sefton et al., 2000)

Phenotypic Data

In combination with other aberrations

Ab(1)os^s/Df(1)os1A2 mutant flies have small eyes compared to wild type. No wing defects are seen.

(Wang et al., 2014)

Df(1)os¹/Df(1)os1A2 mutant flies have outstretched wings and small eyes compared to wild type.

(Wang et al., 2014)

The pupal lethality of Df(2R)P3C homozygotes is partially suppressed by Df(1)os1A2/+.

(Classen et al., 2009)

NOT in combination with other aberrations

The embryonic hindgut of Df(1)os1A2 homozygotes has no obvious morphological defects at stage 12, but has a lower angle of curvature at stage 15, associated with an increased cell height ratio between cells on the inside and outside of the curvature, as compared to controls.

(Wells et al., 2013)

The tracheal tree does not form in Df(1)os1A2 embryos.

(Sotillos et al., 2010)

Tracheal pits fail to form in Df(1)os1A2 mutant embryos.

(Arbouzova et al., 2006)

Df(1)os1A2 mutants exhibit abnormal spiracles due to a lack of cell elongation.

(Lovegrove et al., 2006)

Df(1)os1A2 embryos show segmentation defects, with all segments affected. The posterior spiracles and trachea are missing from these embryos and the mandible is abnormal.

(Hombria et al., 2005)

The proliferation of germ cells in male Df(1)os1A2 embryos is reduced compared to controls.

(Wawersik et al., 2005)

The hindgut is only about half the normal length and is somewhat wider than normal in homozygous embryos. There are a greater number of cells in the circumference of the mutant hindgut than in wild type. The total number of hindgut epithelial cells is 96% of wild type. The hindgut visceral mesoderm appears normal in mutant embryos.

(Johansen et al., 2003)

In Df(1)os1A2 homozygous embryos, the evagination and folding steps of proventriculus morphogenesis occur, but the involution and insertion steps do not.

(Johansen et al., 2003)

Homozygous clones within the eye field show no phenotype either in imaginal discs or in the adult eye. Clones adjacent to the optic stalk produce almost complete dorsalisation of the eye field as assayed by ommatidial polarity.

(Zeidler et al., 1999)

Df(1)os1A2 embryos show loss of the fifth abdominal denticle band and the posterior mid-ventral portion of the fourth band. Variable reduction of the second thoracic and eighth abdominal denticle bands and variable fusion of the sixth and seventh denticle bands is seen.

(Harrison et al., 1998)

Stocks (0)

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

It has been determined using in situ and PCR that Df(1)os1A2 deletes os, upd2, upd3.

(Brown et al., 2003)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Df(1)os1A

(Molina-Gil et al., 2023, Sotillos et al., 2022, Sánchez-Higueras et al., 2019, Pinto et al., 2015, Sánchez-Higueras et al., 2014, Wells et al., 2013, Rivas et al., 2008, Sotillos et al., 2008, Lovegrove et al., 2006, Gilbert et al., 2005, Brown et al., 2003)

Df(1)os1A2

Df(1)os1a

(Wang et al., 2014)

Df(1)os^1A

(Arbouzova et al., 2006, Hombria et al., 2005, Karsten et al., 2002, Harrison et al., 1998, Sanchez et al., 1994, Klingler and Gergen, 1993, Ferrus et al., 1990)

Df(1)os^1a

(Wawersik et al., 2005, Sefton et al., 2000)

Dfos1A

(Sotillos et al., 2010)

os1A

(Tsai and Sun, 2004, Agaisse et al., 2003, Bach et al., 2003)

os^1A

upd^1A

(Classen et al., 2009)

upd^OS1A

(Arbouzova et al., 2006)

upd^os1A

(Johansen et al., 2003, Johansen et al., 2003, Tsai and Sun, 2001, Zeidler et al., 1999)

Name Synonyms

Secondary FlyBase IDs

FBal0097931

References (32)

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