Aberration Dmel\Df(1)rb1

General Information
Symbol	Dmel\Df(1)rb1	Species	D. melanogaster
Name	Deficiency (1) ruby	FlyBase ID	FBab0000894
Feature type	chromosomal_deletion
Also Known As	Df(1)rb¹

Computed Breakpoints include	3F6-4A1;4C7
Deleted segment	3F6--4C7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Banga et al., 1986)
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995)
Breakpoints	3F6-4A1;4C7-4C8 (Pauli et al., 1995) 4A3-4A6;4C6-4C7 (Goode et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	cho << bk1 << mdl << peb << bk2 << rap
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Pflugfelder et al., 1991)
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0080317) Left limit of break 2 from polytene analysis (FBrf0080317) Right limit of break 2 from polytene analysis (FBrf0089663)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	amb (Oliver et al., 1988) bi (Oliver et al., 1988) brn (Oliver et al., 1988, Goode et al., 1996) lac (Oliver et al., 1988) mdl (Goode et al., 1996) mei-9 (Oliver et al., 1988) norpA (Banga et al., 1986, Oliver et al., 1988) peb (Oliver et al., 1988) rb (Banga et al., 1986, Oliver et al., 1988)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cho (Oliver et al., 1988, Goode et al., 1996) cv (Oliver et al., 1988) ec (Oliver et al., 1988) fs(1)A456 (Oliver et al., 1988) fs(1)A1059 (Oliver et al., 1988) ovo (Oliver et al., 1988) rg (Oliver et al., 1988) snf (Oliver et al., 1988)
Molecular Data
	rap (Sigrist and Lehner, 1997)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(1)rb1 embryos lose tracheal integrity. The tracheal lumen becomes discontinuous and misshapen. (Wilk et al., 2000) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(1)rb1 Df(1)rb¹ (Kretzschmar et al., 2000, Wilk et al., 2000, Goode et al., 1996, Banga et al., 1986, Oliver et al., 1988)
Name Synonym	Deficiency (1) ruby
Secondary FlyBase IDs

References ( 11 )
Research paper	Kretzschmar et al., 2000, Genetics 155(1): 213--223 Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3 adaptin gene ruby. [FBrf0127175] Wilk et al., 2000, Dev. Biol. 219(2): 183--196 The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila. [FBrf0127390] Sigrist and Lehner, 1997, Cell 90(4): 671--681 Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. [FBrf0098351] Goode et al., 1996, Dev. Biol. 178(1): 35--50 brainiac encodes a novel, putative secreted protein that cooperates with Grk TGF in the genesis of the follicular epithelium. [FBrf0089663] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Oliver et al., 1988, Genetics 120: 159--171 Genetic evidence that the sans fille locus is involved in Drosophila sex determination. [FBrf0048195] Banga et al., 1986, Chromosoma 93: 341--346 Cytogenetic characterization of the 4BC region on the X chromosome of Drosophila melanogaster: localization of the mei-9, norpA and omb genes. [FBrf0043953]
Abstract	Pflugfelder et al., 1991, Greenspan, Palka, 1991: 143 Gene products of the l(1) optomotor-blind gene of Drosophila melanogaster are essential for correct brain and wing development. [FBrf0053304]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]