Aberration Dmel\Df(1)rst2

General Information
Symbol	Dmel\Df(1)rst2	Species	D. melanogaster
Name	Deficiency (1) roughest	FlyBase ID	FBab0000919
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << rst << vt << bk2
Sequence coordinates
Deleted segment	3C3--3C6
Duplicated segment
Computed Breakpoints include	3C3;3C6
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous (Lefevre and Green, 1972)
Class of aberration (relative to progenitor)	chromosomal_deletion (Lefevre and Green, 1972, Judd, 1995, Welshons and Welshons, 1986, Gubb et al., 1984, Smolik-Utlaut and Gelbart, 1987, Gubb et al., 1985)
Breakpoints	3C3;3C5-3C6 (Lefevre and Green, 1972) 3C3-3C4;3C6-3C7 (Gubb et al., 1984, Gubb et al., 1985, Smolik-Utlaut and Gelbart, 1987, Judd, 1995) 3C3;3C5 (Welshons and Welshons, 1986) 3C5;3C7 (Wolff and Ready, 1991)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0023492) Left limit of break 2 from polytene analysis (FBrf0040529) Right limit of break 2 from polytene analysis (FBrf0023492) Ref: FBrf0023492. (Welshons and Welshons, 1986)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	rst (Lefevre and Green, 1972, Smolik-Utlaut and Gelbart, 1987, Judd, 1995, Ruiz-Gomez et al., 2000) vt (Lefevre and Green, 1972, Judd, 1995, Ruiz-Gomez et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	w (Ruiz-Gomez et al., 2000) N (Ruiz-Gomez et al., 2000) kirre (Ruiz-Gomez et al., 2000)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Hemizygous males and homozygous females are viable and fertile though emergence is delayed. z¹ Df(1)rst2 males are rough-eyed with wild type eye colour. Homozygous females are rough-eyed with z eye colour. (Judd, 1995) Rough eyes and irregular optic chiasms. (Ramos et al., 1993) Semilethal. (Gubb et al., 1985) Timing of adult emergence is delayed. (Lefevre and Green, 1972) hemizygous male viable homozygous female viable hemizygous and homozygous emergence delayed (Lefevre and Green, 1972, Chromosoma 36: 391-412).
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	91 Df(1)rst2/FM1, lz⁺
Kyoto	105727 Df(1)rst2/FM1, lz⁺ 101019 C(1)DX, y¹ w¹ f¹ / Df(1)rst2
Notes on Origin
Discoverer	Bridges, 7th April 1933.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Interacts with N^fa-swb to suppress eye roughening. (Wolff and Ready, 1991)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(1)rst2 Df(1)rst² (Ruiz-Gomez et al., 2000, Gubb et al., 1985, Smolik-Utlaut and Gelbart, 1987, Gubb et al., 1984, Welshons and Welshons, 1986, Araujo et al., 1996, Lefevre and Green, 1972, Ramos et al., 1993) Df rst² (Lefevre, 1970) rst² (Wolff and Ready, 1991, Duus et al., 1992)
Name Synonym	Deficiency (1) roughest
Secondary FlyBase IDs

References ( 18 )
Research paper	Harbison et al., 2004, Genetics 166(4): 1807--1823 Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. [FBrf0174696] Ruiz-Gomez et al., 2000, Cell 102(2): 189--198 Drosophila dumbfounded: a myoblast attractant essential for fusion. [FBrf0130056] Judd, 1995, Genetics 141(1): 245--253 Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster. [FBrf0084074] Ramos et al., 1993, Genes Dev. 7(12B): 2533--2547 The irregular chiasm-C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein. [FBrf0065542] Duus et al., 1992, Dev. Biol. 151: 34--47 Blackpatch, a neural degeneration mutation that interacts with the Notch locus in Drosophila. [FBrf0055810] Wolff and Ready, 1991, Development 113(3): 825--839 Cell death in normal and rough eye mutants of Drosophila. [FBrf0053823] Smolik-Utlaut and Gelbart, 1987, Genetics 116: 285--298 The effects of chromosomal rearrangements on the zeste-white interaction in Drosophila melanogaster. [FBrf0046365] Welshons and Welshons, 1986, Genetics 113(2): 337--354 Enhancement and suppression of a euchromatic position effect at Notch in Drosophila melanogaster. [FBrf0044443] Gubb et al., 1985, Chromosoma 92: 116--123 A preliminary genetic analysis of TE146, a very large transposing element of Drosophila melanogaster. [FBrf0042115] Gubb et al., 1984, Chromosoma 91: 54--64 The genetic analysis of a large transposing element of Drosophila melanogaster. The insertion of a w<up>+</up> rst<up>+</up> TE into the ck locus. [FBrf0040529] Lefevre and Green, 1972, Chromosoma 36: 391--412 Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster. [FBrf0023492] Lefevre, 1970, D. I. S. 45: 32 [New mutants report.] [FBrf0063629] Gersh, 1965, Genetics 51: 477--480 A new locus in the white-notch region of the Drosophila melanogaster x chromosome. [FBrf0017054] Emmens, 1937, J. Genet. 34: 191--202 Salivary gland cytology of roughest<up>3</up> inversion and reinversion, and roughest<up>2</up>. [FBrf0003931] Gruneberg, 1937, J. Genet. 34: 169--189 The position effect proved by a spontaneous reinversion of the X-chromosome of Drosophila melanogaster. [FBrf0003930]
Abstract	Araujo et al., 1996, A. Dros. Res. Conf. 37: 253 Final steps in ommatidial assembly: characterization of a novel dominant allele of the irregular chiasmC-roughest gene. [FBrf0084678]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]