Aberration Dmel\Df(1)sc10-1

General Information
Symbol	Dmel\Df(1)sc10-1	Species	D. melanogaster
Name		FlyBase ID	FBab0000928
Feature type	chromosomal_deletion

Computed Breakpoints include	1B1-1B2;1B2-1B3
Deleted segment	1B1--1B3
Sequence coordinates
Recent Updates
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FB2011_10
FB2012_01	Stocks In(1)ac[3], sc[10-1] ac[3] w[1] s[1]/FM7i, P{w[+mC]=ActGFP}JMR3 References Johnson et al., 2011, Dev. Dyn. 240(7): 1769--1778
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Nature of the Aberration
Cytological Order	1Lt - 1B1 \| 1B14 - 1B3 \| 1C1 - 1Rt
Progenitor	In(1)ac³ (Villares and Cabrera, 1987)
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Duffy et al., 1996)
Breakpoints	1B2;1B2 (Duffy et al., 1996)
Causes alleles	sc^10-1 (Held, 1990, Villares and Cabrera, 1987, Marcellini et al., 2005, Rodriguez et al., 1990, Jack et al., 1991, Erickson and Cline, 1991, Jack and DeLotto, 1992, Gonzalez-Crespo and Levine, 1993, Lindsley and Zimm, 1992, van Doren et al., 1994, Gomez-Skarmeta et al., 1995, Parks et al., 1997, Reeves and Posakony, 2005)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << ac << sc << bk2
Genetic mapping information
Comments	Maintains intact sc regulatory regions. (Cubas et al., 1991)
Comments on Cytology
	Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of ac (FBrf0042024) Left limit of break 2 from inclusion of sc (FBrf0042024) Right limit of break 2 from polytene analysis (citation unavailable)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ac (Campuzano et al., 1985, Brown et al., 1991, Jack et al., 1991, Duffy and Gergen, 1991, Cubas et al., 1991, Martinez and Modolell, 1991, Jack and DeLotto, 1992, Gonzalez-Crespo and Levine, 1993, Hinz et al., 1994, van Doren et al., 1994, Ramaekers et al., 1995, Gomez-Skarmeta et al., 1995, Bailey and Posakony, 1995, Leviten and Posakony, 1996, Gupta and Rodrigues, 1997, Henrique et al., 1997, Jimenez and Ish-Horowicz, 1997) sc (Campuzano et al., 1985, Brown et al., 1991, Jack et al., 1991, Duffy and Gergen, 1991, Cubas et al., 1991, Martinez and Modolell, 1991, Jack and DeLotto, 1992, Gonzalez-Crespo and Levine, 1993, Hinz et al., 1994, van Doren et al., 1994, Ramaekers et al., 1995, Gomez-Skarmeta et al., 1995, Bailey and Posakony, 1995, Leviten and Posakony, 1996, Gupta and Rodrigues, 1997, Henrique et al., 1997, Jimenez and Ish-Horowicz, 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Hemizygous pharate adult males completely lack interommatidial bristles. (Pepple et al., 2007) Df(1)sc10-1 adults lack all external sensory organs in the notum. (Pi et al., 2004) Mutant adults have no bristles on the notum, but have a normal pattern of correctly attached flight muscles. (Usui et al., 2004) Df(1)sc10-1/Y flies have a bald notum. (Giagtzoglou et al., 2003) Df(1)sc10-1/Y flies are almost completely bald, lacking most mechanosensory organs. Most sensory organ precursor cells are missing in the wing discs of these animals. (Lai, 2003) Flies are almost devoid of micro- and macrochaetae. (Nolo et al., 2000) Flies hemizygous for Df(1)sc10-1 have bald nota, no SOPs are specified. (Apidianakis et al., 1999) Flies lack all sensory bristles. Scer\GAL4^455.2-mediated expression of Ggal\Cash4^Scer\UAS.cHa in the scutellar primordia induces ectopic scutellar bristles. (Henrique et al., 1997) Olfactory sensilla on the surface of the third antennal segment develop normally in Df(1)sc10-1 flies. (Reddy et al., 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Glial cells of wing nerves are absent in adult wing and almost completely absent in the developing wing. (Giangrande, 1995) Homozygotes exhibit few bristles. Heat induced expression of P{CnASH} induces bristle formation on the thorax and distal segments of the legs. (Grens et al., 1995) Loss of all bristles on the notum. (Hinz et al., 1994) Hemizygotes fail to develop most of the adult external mechanosensory organs (FBrf0045760). Flies have low viability associated with severe uncoordination: unable to walk or stay upright. (Kernan et al., 1994) Viability is low although a few hemizygous males survive to adulthood. two P-type (P3 and P4) and one S-type bristle are present on the proboscis of surviving hemizygotes, all other bristles normally present on the proboscis are absent. Df(1)sc10-1 flies carrying sc^hs.PR can develop the complete labellum bristle pattern, when they are heat shocked at 0, 6 and 12 hours after puparium formation. (Ray and Rodrigues, 1994) Introduction of ac[T52.2] construct into an ac[-] sc[-] h[-] background causes ectopic bristles to appear along wing vein L5. (van Doren et al., 1994) The extreme sc phenotype may result from a combination of the truncated sc protein and the effect of the In(1)ac³ breakpoint on the transcription of ac. (Villares and Cabrera, 1987) male viability low The adults, which occasionally eclose, lack macro- and microchaetae, except those of the eye and wing margin. Homozygous cell clones in wing lack neurons except along anterior margin (Schubiger and Palka, 1985, Dev. Biol. 108: 399-410).
Stocks ( 4 )
Bloomington	109 Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1 6016 Df(1)sc10-1, sc^10-1 f^36a/FM6/Dp(1;Y)y²67g19.1
Kyoto	105739 Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1 108554 Df(1)sc10-1, f^36a / FM6 / Dp(1;Y)y²67g19.1
Notes on Origin
Discoverer	Sturtevant, 1930.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	No deletion is detected in the cloned ac region. The parent In(1)ac³ breaks very close to the 5' of ac. (Campuzano et al., 1985)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(1)sc10-1 (Stagg et al., 2011) Df(1)sc10-1, sc^10-1 (Jafar-Nejad et al., 2003) Df(1)sc^10-1 (Giagtzoglou et al., 2003, Apidianakis et al., 1999, Jimenez and Ish-Horowicz, 1997, Henrique et al., 1997, Villares and Cabrera, 1987, Held, 1990) In(1)ac³sc^10-1 (Usui et al., 2004) In(1)ac³sc^10.1 (van de Bor et al., 2002) In(1)sc^10-1 (Lai, 2003, Cadigan et al., 2002, del Alamo et al., 2002, Klein and Campos-Ortega, 1997, Jennings et al., 1995, Brown et al., 1991, Moeller et al., 2005) In(1)sc^10.1 (Escudero et al., 2005, Villa-Cuesta et al., 2003, Culi et al., 2001, Culi and Modolell, 1998, Modolell and Campuzano, 1998, Cubas and Modolell, 1992, Gomez-Skarmeta et al., 1995, Martinez and Modolell, 1991, Dominguez and Campuzano, 1993) sc10.1 (Usui et al., 1995) sc^10-1 (Pi et al., 2004, Giagtzoglou et al., 2003, Ray and Rodrigues, 1994, Reddy et al., 1997, Leviten and Posakony, 1996, Pepple et al., 2007, Johnson et al., 2011) sc^10.1 (Grillenzoni et al., 1998, Klein and Campos-Ortega, 1997, Ramaekers et al., 1995)
Name Synonym
Secondary FlyBase IDs
	FBab0027885
References ( 66 )

Generate a list of	All references relating to this aberration ( 66 )

List References by type	Research paper ( 60 ) Review ( 2 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Johnson et al., 2011, Dev. Dyn. 240(7): 1769--1778 Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development. [FBrf0213950] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...