FlyBase Aberration Report: Dmel\Df(1)svr

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Aberration: Dmel\Df(1)svr

General Information

Symbol

Df(1)svr

Species

D. melanogaster

Name

Deficiency (1) silver

FlyBase ID

FBab0000974

Feature type

chromosomal_deletion

Computed Breakpoints include

1A1;1B13

Features within 1A1--1B13

Genomic Maps

Sequence coordinates

X:1..258,469 (Df(1)svr:bk1)

(Cook, 2016.2.8)

X:635,019..660,484 (Df(1)svr:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

(California Institute of Technology, 1940)

(Eeken and Sobels, 1990)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Park and Yamamoto, 1993, Watson et al., 1991, Eeken and Sobels, 1990, Prudhommeau and Proust, 1990, Voelker et al., 1989, Sherald and Voelker, 1985, Sutton, 1943)

Breakpoints

1A1;1B9-1B10

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Eeken and Sobels, 1990, Sutton, 1943)

XLt;1B10-1B13

(Watson et al., 1991, Prudhommeau and Proust, 1990, Voelker et al., 1989, Sherald and Voelker, 1985)

XLt;1B9-1B10

(Park and Yamamoto, 1993)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << l(1)1Aj << RpL36 << bk2 << su(s)

Genetic mapping information

Comments

The X:1..258469 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the left X tip, because Df(1)svr is likely a terminal deletion. The right extent corresponds to the right end of cin, which published results say is deleted.

(Cook, 2016.2.8)

The X:635019..660484 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the leftmost end of a PCR primer pair flanking the insertion site of P{EPgy2}Dredd^EY08404 from Table S1 of FBrf0212582, which did not amplify a DNA segment from Df(1)svr in tests at the Bloomington Stock Center. The right extent corresponds to the estimated position of the left end of polytene band 1C1, because published cytologies indicate the breakpoint lies to the left of this band.

(Cook, 2016.2.8)

Comments on Cytology

Deletion of 16/17 bands.

(Eeken and Sobels, 1990)

Right break is to the right of 1B9--1B10.

(California Institute of Technology, 1940)

Limits of break 1 from polytene analysis (FBrf0005951) Left limit of break 2 from inclusion of l(1)1Bi (FBrf0086390) Right limit of break 2 from polytene analysis (FBrf0042241)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Bate et al., 1993, Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

(Kramers et al., 1991, Kramers et al., 1983)

(Bate et al., 1993, Corbin et al., 1991, Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1983)

(Kramers et al., 1991)

(Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1991, Kramers et al., 1983)

(Duffy et al., 1996)

(Duffy et al., 1996)

(Bate et al., 1993, Lai and Mackay, 1993, Park and Yamamoto, 1993, Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

(Murphy, 2003, Khush et al., 2002)

(Park and Yamamoto, 1993, Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

(Harbecke and Lengyel, 1995, Bate et al., 1993, Corbin et al., 1991, Kramers et al., 1991, Kramers et al., 1983)

(Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (7)

Related Comments

Phenotypic Data

In combination with other aberrations

Df(1)svr/Df(1)N19 double heterozygous females have reduced viability; only 30% survive compared to control flies. Viability is recovered if the Df(1)svr/Df(1)N19 females also carry Sxl^M1. The viability of Df(1)svr/Df(1)RA2 or Df(1)svr/+ female progeny derived from a cross between Df(1)RA2/+ females and Df(1)svr/Y males is severely reduced.

(Sanchez et al., 1994)

NOT in combination with other aberrations

Mutant embryos have about 72 cells in each Malpighian tubule cell (as opposed to about 125 in wild-type). The addition of btl::Egfr^{Scer\UAS.T:λ\cI-DD} has no effect on the Df(1)svr Malpighian tubule phenotype.

(Sudarsan et al., 2002)

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 65% of run³ heterozygotes. Shows a dominant Minute phenotype: short fine bristles, delayed development and reduced viability.

(Duffy et al., 1996)

Females heterozygous for Df(1)N19 that are derived from da^unspecified/+ mothers show reduced viability at 29^oC.

(Sanchez et al., 1994)

Df(1)svr/N^55e11 mutants show substantial rescue of both the cuticular and muscle phenotypes of N^55e11 embryos. The cuticle has expanded both in the anteroposterior and in the dorsoventral axes, although there is still no sign of denticle belts. Muscle phenotype shows many of the fibres are oriented and attached in a clearly patterned fashion. At the ventral margins of the cuticular shield the muscles appear disorganised with unfused fibres.

(Bate et al., 1993)

Hemizygous embryos were examined with polarised light microscopy and antibody staining: muscle pattern incomplete due to muscle absences and detachments.

(Drysdale et al., 1993)

Embryos show missing elements in the CNS pattern.

(Corbin et al., 1991)

Heterozygous females exhibit reduced viability and fertility.

(Eeken and Sobels, 1990)

All es and most of the nd neurons are removed, ch neurons are not affected. Neurons are more disorganized in the ventral region.

(Dambly-Chaudiere and Ghysen, 1987)

Lethal in homozygous and hemizygous condition.

(Sutton, 1943)

Flies show frequent absence of the postvertical, orbital and abdominal bristles.

(California Institute of Technology, 1940)

Embryonic lethal abnormal development of nervous system and cell lethal (Ripoll and Garcia-Bellido).

Stocks (4)

1028

Df(1)svr, N^spl-1/C(1)DX, y¹ f¹; Dp(1;f)101

901

Df(1)svr, N^spl-1 ras² fw¹/Dp(1;Y)y²67g19.1/C(1)DX, y¹ f¹

106175

Df(1)svr, N^spl-1/C(1)DX, y¹ f¹; Dp(1;f)101

106108

Df(1)svr, N^spl-1 ras² fw¹/Dp(1;Y)y²67g19.1/C(1)DX, y¹ f¹

Notes on Origin

Discoverer

L.V. Morgan, 31st Oct. 1939

(California Institute of Technology, 1940)

L.V. Morgan.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Df(1)svr

(Li et al., 2020, Sawyer et al., 2020, Johns et al., 2018)

Df(1)svrLVM

(Sutton, 1943)

Df[1]svr

(Swick et al., 2013)

Dfsvr

(Bate, 1993, Kramers et al., 1991)

svr

(Sanchez et al., 1994)

Name Synonyms

Deficiency (1) silver

Deficiency(1)silver L. V. Morgan

(Sutton, 1943)

Secondary FlyBase IDs

References (41)

Report Sections