A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(1)w67k30

General Information
SymbolDmel\Df(1)w67k30SpeciesD. melanogaster
NameFlyBase IDFBab0001042
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data crm << bk1 << w << su(fa<up>swb</up>) << bk2 << N
Sequence coordinates
Deleted segment3C2--3C6
Duplicated segment
Computed Breakpoints include 3C2;3C6
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Lefevre and Green, 1972, Eeken and Sobels, 1990, Lefevre, 1970)
P-element activity
(Dworak et al., 2001)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Lefevre and Green, 1972, Welshons, 1974, Eeken and Sobels, 1990, Lefevre, 1970, Lefevre, 1971)
Breakpoints
3C2;3C6
(Lefevre and Green, 1972, Lefevre, 1970, Lefevre, 1971)
3C1;3C6
(Welshons, 1974)
3C1-3C2;3C6-3C7
(Eeken and Sobels, 1990)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Deletes 5' half of the transcription unit immediately upstream of N (Kidd, Kelley and Young, 1986, Mol. Cell Biol. 6: 3094-3108)
 
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0023492) Right limit of break 1 from inclusion of w (FBrf0023492) Limits of break 2 from polytene analysis (FBrf0023492)
 
Deletion of 5/6 bands.
(Eeken and Sobels, 1990)
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
w
(Lefevre and Green, 1972, Kramers et al., 1983, Kramers et al., 1991, Ruiz-Gomez et al., 2000)
kirre
(Ruiz-Gomez et al., 2000, Chen et al., 2003)
rst
(Lefevre and Green, 1972, Kramers et al., 1983, Kramers et al., 1991, Ruiz-Gomez et al., 2000, Chen et al., 2003)
vt
(Lefevre and Green, 1972, Ruiz-Gomez et al., 2000)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Actn
(Kramers et al., 1991)
Pgd
(Kramers et al., 1991)
pn
(Kramers et al., 1991)
phl
(Kramers et al., 1991)
crn
(Kramers et al., 1991)
kz
(Kramers et al., 1991)
wapl
(Kramers et al., 1991)
wds
(Kramers et al., 1991)
egh
(Kramers et al., 1991)
tko
(Kramers et al., 1991)
gt
(Kramers et al., 1991)
sgg
(Kramers et al., 1991)
dwg
(Kramers et al., 1983, Kramers et al., 1991)
crm
(Kramers et al., 1983, Kramers et al., 1991)
N
(Welshons, 1974, Kramers et al., 1983, Kramers et al., 1991, Ruiz-Gomez et al., 2000)
dm
(Kramers et al., 1991)
trol
(Kramers et al., 1991)
z
(Kramers et al., 1991)
mit(1)15
(Kramers et al., 1991)
l(1)3Ah
(Kramers et al., 1991)
l(1)3Da
(Kramers et al., 1991)
l(1)2Dk
(Kramers et al., 1991)
l(1)3Al
(Kramers et al., 1991)
l(1)EA65
(Kramers et al., 1991)
l(1)3Ed
(Kramers et al., 1991)
l(1)3-64
(Kramers et al., 1991)
l(1)3Bb
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Bf
(Kramers et al., 1983, Kramers et al., 1991)
l(1)3Ao
(Kramers et al., 1991)
l(1)2Dj
(Kramers et al., 1991)
l(1)ESHS14
(Kramers et al., 1991)
l(1)2Ff
(Kramers et al., 1991)
l(1)2Ea
(Kramers et al., 1991)
l(1)3Eb
(Kramers et al., 1991)
l(1)3Aj
(Kramers et al., 1991)
l(1)2Fg
(Kramers et al., 1991)
l(1)2Dm
(Kramers et al., 1991)
l(1)3Ap
(Kramers et al., 1991)
l(1)2Fd
(Kramers et al., 1991)
l(1)7-103
(Kramers et al., 1991)
l(1)3Bg
(Kramers et al., 1991)
l(1)3ABa
(Kramers et al., 1991)
l(1)3Am
(Kramers et al., 1991)
l(1)2Fc
(Kramers et al., 1991)
l(1)2Dl
(Kramers et al., 1991)
l(1)3Bd
(Kramers et al., 1983, Kramers et al., 1991)
l(1)2Ed
(Kramers et al., 1991)
l(1)3ABb
(Kramers et al., 1991)
l(1)3Ak
(Kramers et al., 1991)
l(1)3Aq
(Kramers et al., 1991)
l(1)2Fb
(Kramers et al., 1991)
l(1)3An
(Kramers et al., 1991)
l(1)2Ec
(Kramers et al., 1991)
l(1)3Bc
(Kramers et al., 1983, Kramers et al., 1991)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Embryos show a complete lack of fusion in the somatic mesoderm and gaps in the visceral mesoderm, whereas other mesodermal derivatives, such as fat body, gonads and heart develop normally. Myoblast fusion fails completely in Df(1)w67k30 embryos. Founder cells and fusion-competent myoblasts remain at different levels in the mesoderm, with the founders in close contact with the ectoderm, whereas the rest of the myoblasts are more internal. The myoblasts do extend filopodia, but they are randomly oriented and show no sign of being attracted preferentially toward the founders. At later stages, founder cells elongate to form mononucleate muscles that span the territory that they would have occupied as syncytia in wild-type embryos. A normal pattern of innervation by motorneurons is seen. Fusion competent myoblasts die and are eliminated by macrophages. Df(1)w67k30 embryos show an early defect in visceral mesoderm formation; instead of two bands of tightly packed visceral muscles, several gaps are seen. These gaps are not due to a reduction in the precursors, instead they might be a consequence of improper alignment or adhesion of the visceral muscles.
(Ruiz-Gomez et al., 2000)
Heterozygous females exhibit slightly reduced viability and fertility.
(Eeken and Sobels, 1990)
Individuals are mutant in eye colour and texture and show the vertical bristle syndrome. Homozygous males are lethal.
(Lefevre and Green, 1972)
Male lethal.
(Lefevre, 1970)
Mutants are embryonic lethal and show no myoblast fusion.
(Strunkelnberg et al., 2001)
Suppresses faswb Cell viable male lethal
 
The palisade of circular visceral muscle founder cells is distinctly separated from the adjacent population of fusion-competent cells in stage 13 mutant embryos, in contrast to wild type where they are closely apposed.
(San Martin et al., 2001)
homozygous lethal Homozygous germline clones produce viable cells.
(Garcia-Bellido and Robbins, 1983)
Founder myoblasts fail to attract fusion-competent myoblasts and myoblast fusion stalls altogether - the average number of eve-positive nuclei within a DA1 muscle at stage 15 is approximately 1 compared to approximately 10 in wild type embryos.
(Menon et al., 2005)
hide Position Effect Variegation Data
  
hide Stocks ( 2 )
Bloomington
6018
Df(1)w67k30, lz1 ras1 v1/FM7c
Kyoto
108556
Df(1)w67k30, lz1 ras1 v1/FM7c
hide Notes on Origin
Discoverer
Baker, 30th November 1967.
(Lefevre, 1970)
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      hide Synonyms & Secondary IDs ( 12 )
      Reported As
      Symbol Synonym
      Df(1)w67k30
       
      Df(1)w67k30-X
       
      Df(1)w67K30
      (Galletta et al., 2004)
      Df(1)w67k30
      (Chen et al., 2003, Menon and Chia, 2001, Artero et al., 2001, Dworak et al., 2001, Strunkelnberg et al., 2001, San Martin et al., 2001, Ruiz-Gomez et al., 2000, Pastink et al., 1987, Lefevre, 1970, Eeken and Sobels, 1990, Pastink et al., 1990, Kramers et al., 1983, Welshons, 1974, Lefevre and Green, 1972, Menon et al., 2005)
      Df(1)w-67k30
      (Garcia-Bellido and Robbins, 1983)
      Dfw67k30
      (Lefevre, 1971, Kramers et al., 1991)
      duf, rst
      (Menon et al., 2005)
      duf; rstDf(1)w67k30
      (Menon et al., 2005)
      duf;rstDf(1)w67k30
      (Menon et al., 2005)
      w67k30
      (Klapper et al., 2002, Welshons and Welshons, 1986)
      w67k30N+
      (Grimwade et al., 1985)
      wrv-X
       
      Name Synonym
      Secondary FlyBase IDs
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