Aberration Dmel\Df(1)y74k24.1

General Information
Symbol	Dmel\Df(1)y74k24.1	Species	D. melanogaster
Name		FlyBase ID	FBab0001099
Feature type	chromosomal_deletion

Computed Breakpoints include	1A1;1B13
Deleted segment	1A1--1B13
Sequence coordinates
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous
Class of aberration (relative to progenitor)	chromosomal_deletion (Voelker et al., 1989, Duffy et al., 1996, Craymer and Roy, 1980)
Breakpoints	1A1;1B5-1B10 (Duffy et al., 1996) 1A1;1B9-1B10 (Craymer and Roy, 1980, Voelker et al., 1989)
Causes alleles	RpL36^y74k24.1 (Duffy et al., 1996)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(1)1Aj << RpL36 << bk2 << su(s)
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0034402) Left limit of break 2 from inclusion of l(1)1Bi (FBrf0049919) Right limit of break 2 from non-inclusion of su(s) (FBrf0049919)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ac (Craymer and Roy, 1980, Kramers et al., 1983, Kramers et al., 1991) cin (Kramers et al., 1983, Kramers et al., 1991) elav (Kramers et al., 1983, Kramers et al., 1991) ewg (Kramers et al., 1983, Kramers et al., 1991) Exp6 (Kramers et al., 1983, Kramers et al., 1991) l(1)1Ac (Kramers et al., 1983, Eeken et al., 1985, Kramers et al., 1991) l(1)1Ad (Kramers et al., 1983, Kramers et al., 1991) l(1)1Ai (Kramers et al., 1983) l(1)1Aj (Kramers et al., 1991) l(1)1Bc (Kramers et al., 1983, Kramers et al., 1991) l(1)1Bg (Voelker et al., 1989) l(1)1Bh (Voelker et al., 1989) l(1)1Bi (Voelker et al., 1989, Duffy et al., 1996) pch (Eeken et al., 1985) RpL36 (Duffy et al., 1996) sc (Craymer and Roy, 1980, Kramers et al., 1983, Kramers et al., 1991) skpA (Khush et al., 2002) svr (Kramers et al., 1983, Kramers et al., 1991) vnd (Kramers et al., 1983, Kramers et al., 1991) y (Craymer and Roy, 1980, Kramers et al., 1983, Kramers et al., 1991)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	br (Eeken et al., 1985, Kramers et al., 1991) brc (Kramers et al., 1983, Voelker et al., 1989, Kramers et al., 1991) dor (Eeken et al., 1985, Kramers et al., 1991) fs(1)N (Perez-Chiesa et al., 1983) l(1)1Bi (Kramers et al., 1983) l(1)1Bk (Kramers et al., 1983, Voelker et al., 1989) l(1)1Ca (Voelker et al., 1989) l(1)1CDa (Eeken et al., 1985) l(1)1CDb (Eeken et al., 1985) l(1)1CDc (Eeken et al., 1985) l(1)1Da (Kramers et al., 1983, Voelker et al., 1989) l(1)1Ec (Eeken et al., 1985, Kramers et al., 1991) l(1)1Eg (Kramers et al., 1991) l(1)1Fc (Kramers et al., 1991) l(1)1Fg (Kramers et al., 1991) l(1)1Fh (Kramers et al., 1991) l(1)ESHS1 (Eeken et al., 1985) l(1)ESHS3 (Eeken et al., 1985) l(1)ESHS4 (Eeken et al., 1985) l(1)ESHS6 (Eeken et al., 1985) l(1)ESHS7 (Eeken et al., 1985) l(1)ESHS8 (Eeken et al., 1985) l(1)ESHS9 (Eeken et al., 1985) l(1)ESHS10 (Eeken et al., 1985) l(1)ESHS11 (Eeken et al., 1985) mul (Eeken et al., 1985, Voelker et al., 1989) RpL36 (Voelker et al., 1989) su(s) (Voelker et al., 1989) tw (Kramers et al., 1983, Voelker et al., 1989, Kramers et al., 1991)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 65% of run³ heterozygotes. Shows a dominant Minute phenotype: short fine bristles, delayed development and reduced viability. Both phenotypes are alleviated by maternal P{1BD#1}. (Duffy et al., 1996)
Stocks ( 3 )
Bloomington	3922 C(1)DX, y¹ w¹ f¹/Df(1)y74k24.1, RpL36^y74k24.1/Dp(1;Y)y²61l
Kyoto	101021 C(1)DX, y¹ w¹ f¹ / Df(1)y74k24.1 / Dp(1;Y)mal⁺ 107269 C(1)DX, y¹ w¹ f¹/Df(1)y74k24.1, RpL36^y74k24.1/Dp(1;Y)y²*
Notes on Origin
Discoverer
	Arose in: y² mutator stock of M.M. Green.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Df(1)74k24.1 (Khush et al., 2002) Df(1)y74k24 (Duffy et al., 1996) Df(1)y74k24.1 Df(1)y^74k24.1 (Perez-Chiesa et al., 1983, Wieschaus et al., 1984, Voelker et al., 1989) Df(1)y^-74k24.1 (Eeken et al., 1985) Dfy^74k24.1 (Kramers et al., 1991) y^74k24.1 (Craymer and Roy, 1980)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Khush et al., 2002, Curr. Biol. 12(20): 1728--1737 A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. [FBrf0151852] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Kramers et al., 1991, Mutat. Res. 252: 17--33 Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane. [FBrf0054740] Voelker et al., 1989, Genetics 122: 625--642 Molecular and genetic organization of the suppressor of sable and Minute(1)1B region in Drosophila melanogaster. [FBrf0049919] Eeken et al., 1985, Mutat. Res. 150: 261--275 Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster. [FBrf0043301] Wieschaus et al., 1984, Roux Arch. dev. Biol. 193: 296--307 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. [FBrf0040178] Kramers et al., 1983, Mutat. Res. 107: 187--201 High proportion of multi-locus deletions among hycanthone-induced X-linked recessive lethals in Drosophila melanogaster. [FBrf0039985] Perez-Chiesa et al., 1983, D. I. S. 59: 160--161 Report of new mutants. [FBrf0039118] Craymer and Roy, 1980, D. I. S. 55: 200--204 Report of New Mutants -- Drosophila melanogaster. [FBrf0034402] Garcia-Bellido, 1979, Genetics 91: 491--520 Genetic analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0033191]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]