Aberration Dmel\Df(2L)30A-C

General Information
Symbol	Dmel\Df(2L)30A-C	Species	D. melanogaster
Name		FlyBase ID	FBab0001390
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	raw << bk1 << Cks30A << l(2)DA2 << bk2 << ms(2)30C
Sequence coordinates
Deleted segment	30A3--30C5
Duplicated segment
Computed Breakpoints include	30A3-30A5;30C5
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	P{wA}4-30 (Lane and Kalderon, 1993)
Mutagen	X ray (Lane and Kalderon, 1993)
Class of aberration (relative to progenitor)	chromosomal_deletion (Lane and Kalderon, 1993, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Boube et al., 1997, Schupbach and Wieschaus, 1989)
Breakpoints	30A;30C (Schupbach and Wieschaus, 1989, Pauli et al., 1995, Harbecke and Lengyel, 1995) 30A3-30A6;30D3-30D4 (Lane and Kalderon, 1993) 29F7-30A1;30C2-30C5 (Kania et al., 1995) 29F7;30C5 (Boube et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0058516) Right limit of break 1 from inclusion of tai (FBrf0067338) Left limit of break 2 from polytene analysis (FBrf0093373) Right limit of break 2 from polytene analysis (FBrf0080145) Ref: Lindsley and Zimm, 1992 (Kania et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	tai (BDGP Project Members, 1994-1999, Spradling et al., 1999) Cks30A (Schupbach and Wieschaus, 1989, Lane and Kalderon, 1993) scat (Castrillon et al., 1993, BDGP Project Members, 1994-1999, Spradling et al., 1999) numb (Lane and Kalderon, 1993, BDGP Project Members, 1994-1999, Harbecke and Lengyel, 1995, Wang et al., 1997, Spradling et al., 1999) hoip (BDGP Project Members, 1994-1999, Kania et al., 1995, Spradling et al., 1999) pelo (Castrillon et al., 1993, BDGP Project Members, 1994-1999, Spradling et al., 1999) Pka-C1 (Lane and Kalderon, 1993, Skoulakis et al., 1993, BDGP Project Members, 1994-1999, Spradling et al., 1999) gcm (Lane and Kalderon, 1993, Kania et al., 1995, Hosoya et al., 1995) Gdi (Lane and Kalderon, 1993) zf30C (Cook, 2002.3.7) und (Cutforth and Gaul, 1999) l(2)k05104 (BDGP Project Members, 1994-1999) l(2)DA2 (Lane and Kalderon, 1993) l(2)X (Lane and Kalderon, 1993) l(2)k05113a (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)N7-8 (Lane and Kalderon, 1993) l(2)DB2 (Lane and Kalderon, 1993) mat(2)cell-K (Schupbach and Wieschaus, 1989) l(2)DB4 (Lane and Kalderon, 1993) mat(2)cell-F (Schupbach and Wieschaus, 1989, Lane and Kalderon, 1993) l(2)DB1 (Lane and Kalderon, 1993) l(2)FE3 (Lane and Kalderon, 1993) l(2)N7-6 (Lane and Kalderon, 1993)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	toc (BDGP Project Members, 1994-1999) l(2)gl (Mason et al., 2004) raw (BDGP Project Members, 1994-1999, Spradling et al., 1999) gcm (BDGP Project Members, 1994-1999) sop (BDGP Project Members, 1994-1999) spen (BDGP Project Members, 1994-1999) ms(2)30C (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)06320 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)s2978 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k01006 (BDGP Project Members, 1994-1999) l(2)DB2 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	83% of hemisegments show an RP2 to RP2sib cell fate transformation in homozygous embryos. (Buescher et al., 1998) Deficient embryos show a mutant midgut phenotype: midgut primordia do not migrate from terminalia. (Bilder and Scott, 1995) Heterozygosity for Df(2L)30A-C results in 2.1% X chromosome nondisjunction and 2.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Intermediate second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 25-75%. (Halsell and Kiehart, 1998) Midgut primordia do not fuse, but remain at the anterior and posterior of the yolk mass in homozygous embryos. The hindgut is somewhat shorter than normal. The Malpighian tubules bud out but do not elongate. (Harbecke and Lengyel, 1995) Shows a dose-sensitive interaction with pb^hs.PB. (Boube et al., 1997) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The Df(2L)30A-C chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	3702 w¹¹¹⁸; Df(2L)30A-C/CyO
Kyoto	107181 w¹¹¹⁸; Df(2L)30A-C/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df30A-C (Vincent et al., 1996) Df(2L)30A;C (Schupbach and Wieschaus, 1989, Harbecke and Lengyel, 1995, Hosoya et al., 1995, Eberhart and Wasserman, 1995, Pauli et al., 1995, Kania et al., 1995, ) Df(2L)30A-C (Swan et al., 2005, Crest et al., 2007) Df(2L)30C (Tran and Berg, 2003, Harris et al., 2003, Abrell et al., 2000, Jackson and Berg, 1999, Boube et al., 1997, Bilder and Scott, 1995, ) Df(2L)A-C (Wang et al., 1997) Df(3L)30A-C (LaJeunesse et al., 2001)
Name Synonym
Secondary FlyBase IDs

References ( 36 )

Generate a list of	All references relating to this aberration ( 36 )

List References by type	Research paper ( 32 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Show all research papers ...