Aberration Dmel\Df(2L)A245

General Information
Symbol	Dmel\Df(2L)A245	Species	D. melanogaster
Name	Deficiency (2L) Aaron	FlyBase ID	FBab0001402
Feature type	chromosomal_deletion

Computed Breakpoints include	35B1-35B2;35B2
Deleted segment	35B1--35B2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (McNabb et al., 1996, Fossett et al., 1994)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996)
Breakpoints	35A4;35B2 (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	elA << bk1 << noc << Adh << bk2 << mol
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of elA (FBrf0038050) Right limit of break 1 from inclusion of Adh (FBrf0038050) Left limit of break 2 from inclusion of Adh (FBrf0038050) Right limit of break 2 from polytene analysis (FBrf0051930)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adh (Roote, 2002.1.15, Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8) mol (McNabb et al., 1996) noc (Ashburner et al., 1982, Davis et al., 1990, Cheah et al., 1994, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) osp (Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ance (Ashburner et al., 1982, Fossett et al., 1994) Arpc1 (Ashburner et al., 1982) b (Ashburner et al., 1982) Ca-α1D (Fossett et al., 1994) ck (Ashburner et al., 1982, Fossett et al., 1994) Cul-3 (Ashburner et al., 1982, Fossett et al., 1994) CycE (Ashburner et al., 1982, Fossett et al., 1994) DNApol-γ35 (Ashburner et al., 1982) dyn-p25 (Ashburner et al., 1982) elA (Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996) elB (Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996) esg (Fossett et al., 1994) kuz (Fossett et al., 1994) l(2)34Db (Ashburner et al., 1982, Fossett et al., 1994) l(2)34Fc (Fossett et al., 1994, Roote et al., 1996, Ashburner et al., 1982) l(2)34Fd (Roote et al., 1996, Ashburner et al., 1982, Davis et al., 1990) l(2)35Bc (Ashburner et al., 1982) l(2)35Bd (Ashburner et al., 1982) l(2)35Be (Ashburner et al., 1982) l(2)35Bg (Ashburner et al., 1982) l(2)35Cc (Fossett et al., 1994) l(2)35De (Fossett et al., 1994) lace (Ashburner et al., 1982, Fossett et al., 1994) mol (Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996, Roote, 1996.8) mRpL4 (Fossett et al., 1994) ms(2)34Fe (Roote et al., 1996, Davis et al., 1990) NimA (Ashburner et al., 1982) NimC3 (Ashburner et al., 1982, Fossett et al., 1994) pburs (Ashburner et al., 1982, Davis et al., 1990, Roote et al., 1996) Pgant35A (Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996) rd (Ashburner et al., 1982) rk (Ashburner et al., 1982, Fossett et al., 1994) RpII33 (Ashburner et al., 1982, Fossett et al., 1994) sna (Ashburner et al., 1982, Fossett et al., 1994) Sos (Ashburner et al., 1982) stc (Ashburner et al., 1982, Fossett et al., 1994) Su(H) (Ashburner et al., 1982) tam (Ashburner et al., 1982) TfIIS (Fossett et al., 1994) wb (Fossett et al., 1994, Ashburner et al., 1982) wek (Fossett et al., 1994) wor (Ashburner et al., 1982, Fossett et al., 1994)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Does not suppress the zeste phenotype in a z¹ w^11E4; Tp(1;2)TE35B homologue. (Gubb et al., 1990)
NOT in combination with other aberrations	Chromosome has no effect on the physical interaction between tandemly duplicated copies of w⁺ and z¹, despite having breakpoints within the critical region. (Gubb et al., 1990)
Stocks ( 2 )
Bloomington	6060 Df(2L)A245, b¹ cn¹ bw¹/CyO, Adh^nB
Kyoto	108574 Df(2L)A245, b¹ cn¹ bw¹/CyO, Adh^nB
Notes on Origin
Discoverer	Aaron.
	selected as ADH null on 1-penten-3-ol.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Reported to delete Adhr in error; see FBrf0141768 for correction. (Roote et al., 1996)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	A245 (Fossett et al., 1994) Df(2L)A245
Name Synonym	Deficiency (2L) Aaron
Secondary FlyBase IDs

References ( 13 )
Research paper	Pasyukova et al., 2000, Genetics 156(3): 1129--1146 Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. [FBrf0131237] McNabb et al., 1996, Genetics 143(2): 897--911 The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. [FBrf0087599] Roote et al., 1996, D. I. S. 77: 55--65 Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422] Cheah et al., 1994, Mol. Cell. Biol. 14(2): 1487--1499 The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger protein involved in the development of the embryonic brain and the adult ocellar structures. [FBrf0066938] Fossett et al., 1994, Mutat. Res. 307(1): 213--222 The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. [FBrf0073088] Davis et al., 1990, Genetics 126: 105--119 The molecular analysis of the el-noc complex of Drosophila melanogaster. [FBrf0051916] Gubb et al., 1990, Genetics 126: 167--176 A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930] Ashburner et al., 1983, Genetics 104: 405--431 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455] Ashburner et al., 1982, Genetics 102: 421--435 The genetics of a small autosomal region of Drosophila melanogaster, including the structural gene for alcohol dehydrogenase. [FBrf0038050]
Personal communication to FlyBase	Roote, 2002.1.15, Adhr status unknown. Adhr status unknown. [FBrf0141768] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]