FlyBase Aberration Report: Dmel\Df(2L)A400

General Information

Symbol

Df(2L)A400

Species

D. melanogaster

Name

Deficiency (2L) Aaron

FlyBase ID

FBab0001413

Feature type

chromosomal_deletion

Computed Breakpoints include

35A1-35A4;35C1-35C3

Deleted Segment

35A1--35C3

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Fossett et al., 1994, Ashburner, 1982)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Roote et al., 1996, Gubb et al., 1990)

Breakpoints

35A1-35A4;35B10

(Roote et al., 1996, Gubb et al., 1990)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Pgant35A << bk1 << elB << stc << bk2 << rd

Genetic mapping information

Comments

Comments on Cytology

Adhr status unknown.

(Roote, 2002.1.15)

Left limit of break 1 from polytene analysis (FBrf0051930) Right limit of break 1 from inclusion of elB (FBrf0051916) Left limit of break 2 from inclusion of TfIIS (FBrf0073088) Right limit of break 2 from non-inclusion of esg (FBrf0073088)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Adh

(Roote et al., 1996, Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

CIAPIN1

(Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

DCTN5-p25

(Roote, 2010.1.4, Ashburner, 1982, Ashburner et al., 1982)

elA

(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

elB

(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990)

l(2)35Be

(Ashburner, 1982, Ashburner et al., 1982)

mol

(Roote et al., 1996, Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

noc

(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

osp

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Pburs

(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

ppk

(Ainsley et al., 2003)

Rnmt

(Ashburner, 1982, Ashburner et al., 1982)

stc

(Roote et al., 1996, Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982)

Su(H)

(Ashburner, 1982, Ashburner et al., 1982)

TfIIS

(Fossett et al., 1994)

THG

(Ashburner, 1982, Ashburner et al., 1982)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Ance

(Fossett et al., 1994, Ashburner et al., 1982)

Arpc1

(Ashburner et al., 1982)

Ca-α1D

(Fossett et al., 1994)

Cul3

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

CycE

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

DNApol-γ35

(Ashburner et al., 1982)

esg

(Fossett et al., 1994)

kuz

(Fossett et al., 1994)

l(2)34Db

(Fossett et al., 1994, Ashburner et al., 1982)

l(2)34Fc

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

l(2)34Fd

(Roote et al., 1996, Davis et al., 1990, Ashburner et al., 1982)

l(2)35De

(Fossett et al., 1994)

lace

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

mRpL4

(Fossett et al., 1994)

ms(2)34Fe

(Roote et al., 1996, Davis et al., 1990)

NimA

(Ashburner et al., 1982)

NimC3

(Fossett et al., 1994, Ashburner et al., 1982)

Pgant35A

(Flores and Engels, 1999, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

Pol32

(Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

(Fossett et al., 1994, Ashburner et al., 1982)

RpII33

(Fossett et al., 1994, Ashburner et al., 1982)

sna

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

Sos

(Ashburner et al., 1982)

stc

(Ashburner et al., 1982)

tam

(Ashburner et al., 1982)

Uxt

(Fossett et al., 1994)

(Fossett et al., 1994, Ashburner et al., 1982)

wek

(Fossett et al., 1994)

wor

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Related Comments

Phenotypic Data

In combination with other aberrations

Df(2L)A400/Df(2L)b88h49 animals are viable as larvae and adults, with no morphological or behavioural abnormalities easily detected during routine culture. Df(2L)A400/Df(2L)b88h49 larvae do not have defects in multiple dendritic neuron morphology. The larvae are normal in their response to external touch with an eyelash or single hair and show a normal response to four different odours in an olfactory taxis assay. The larvae are indistinguishable from wild type in their ability to respond to a hot probe (pain assay). Df(2L)A400/Df(2L)b88h49 third instar larvae move with a decreased number of stops or turns compared to wild-type larvae, resulting in an extended straight or slightly arching contour trail and a total contour trail area nearly twice that of wild-type larvae. Crawling speed during a linear locomotion burst is increased in the mutant larvae compared to wild type. The mutant larvae complete a full contraction wave cycle in only 1.11 seconds compared to 1.94 seconds in wild-type larvae, due to a more rapid progression of the contraction wave from posterior to anterior and a significant decrease in the length of the pause period between contraction waves

(Ainsley et al., 2003)

Df(2L)b83d29a/Df(2L)A400 is Pburs^-.

(Davis, 2001.4.23)

Viable in combination with Df(2L)b88h49.

(Ashburner et al., 1999)

Df(2L)A400/Df(2L)b83d29a animals do not usually survive to adulthood, rare escapers have crippled legs and show "elbow" and Pburs phenotypes. Df(2L)A400/Df(2L)b84a2 animals die as pharate adults with crippled legs.

(Davis et al., 1997)

Weakly suppresses the zeste phenotype in a z¹ w^11E4; Tp(1;2)TE35B homologue.

(Gubb et al., 1990)

NOT in combination with other aberrations

Df(2L)A400/Df(2L)b88h49 mutant adults do not show any defects in sensing food hardness and like the wild-type flies prefer softer food with lower sugar content (0.5mM sucrose, 0.2% agarose) to a hard food with higher sugar content (1mM sucrose, 2% agarose) in a binary choice assay.

(Jeong et al., 2016)

The Df(2L)A400 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Chromosome acts as a weak trans-suppressor of a physical interaction between tandemly duplicated copies of w⁺, an interaction that is required for the suppression of genes by z¹.

(Gubb et al., 1990)

Stocks (2)

Bloomington

25128

Df(2L)A400, T(2;3;4)CA4, b¹ cn¹ bw¹/CyO, Adh^nB

Kyoto

108708

T(2;3;4)CA4, Df(2L)A400, b¹ cn¹ bw¹/CyO, Adh^nB

Notes on Origin

Discoverer

Aaron.

selected as ADH null on 1-penten-3-ol. Induced with, but genetically separable from T(2;3;4)CA4.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Reported to delete Adhr in error; see FBrf0141768 for correction.

(Roote et al., 1996)

Chromosome also carries T(2;3;4)CA4.

(Ashburner et al., 1982)

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

A400

(Fossett et al., 1994)

Df(2L)A400

(Roote, 2010.1.4)

Δppk

(Jeong et al., 2016)

Name Synonyms

Deficiency (2L) Aaron

Secondary FlyBase IDs

References (21)

Report Sections

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