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General Information
Symbol
Df(2L)A400
Species
D. melanogaster
Name
Deficiency (2L) Aaron
FlyBase ID
FBab0001413
Feature type
Computed Breakpoints include
35A1-35A4;35C1-35C3
Deleted Segment
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Pgant35A << bk1 << elB << stc << bk2 << rd
Genetic mapping information
Comments
Comments on Cytology
Adhr status unknown.
Left limit of break 1 from polytene analysis (FBrf0051930) Right limit of break 1 from inclusion of elB (FBrf0051916) Left limit of break 2 from inclusion of TfIIS (FBrf0073088) Right limit of break 2 from non-inclusion of esg (FBrf0073088)
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
Df(2L)A400/Df(2L)b88h49 animals are viable as larvae and adults, with no morphological or behavioural abnormalities easily detected during routine culture. Df(2L)A400/Df(2L)b88h49 larvae do not have defects in multiple dendritic neuron morphology. The larvae are normal in their response to external touch with an eyelash or single hair and show a normal response to four different odours in an olfactory taxis assay. The larvae are indistinguishable from wild type in their ability to respond to a hot probe (pain assay). Df(2L)A400/Df(2L)b88h49 third instar larvae move with a decreased number of stops or turns compared to wild-type larvae, resulting in an extended straight or slightly arching contour trail and a total contour trail area nearly twice that of wild-type larvae. Crawling speed during a linear locomotion burst is increased in the mutant larvae compared to wild type. The mutant larvae complete a full contraction wave cycle in only 1.11 seconds compared to 1.94 seconds in wild-type larvae, due to a more rapid progression of the contraction wave from posterior to anterior and a significant decrease in the length of the pause period between contraction waves
Viable in combination with Df(2L)b88h49.
Df(2L)A400/Df(2L)b83d29a animals do not usually survive to adulthood, rare escapers have crippled legs and show "elbow" and Pburs phenotypes. Df(2L)A400/Df(2L)b84a2 animals die as pharate adults with crippled legs.
Weakly suppresses the zeste phenotype in a z1 w11E4; Tp(1;2)TE35B homologue.
NOT in combination with other aberrations
Df(2L)A400/Df(2L)b88h49 mutant adults do not show any defects in sensing food hardness and like the wild-type flies prefer softer food with lower sugar content (0.5mM sucrose, 0.2% agarose) to a hard food with higher sugar content (1mM sucrose, 2% agarose) in a binary choice assay.
The Df(2L)A400 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).
Chromosome acts as a weak trans-suppressor of a physical interaction between tandemly duplicated copies of w+, an interaction that is required for the suppression of genes by z1.
Stocks (2)
Notes on Origin
Discoverer
Aaron.
 
selected as ADH null on 1-penten-3-ol. Induced with, but genetically separable from T(2;3;4)CA4.
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Reported to delete Adhr in error; see FBrf0141768 for correction.
Chromosome also carries T(2;3;4)CA4.
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Deficiency (2L) Aaron
Secondary FlyBase IDs
    References (21)