Aberration Dmel\Df(2L)A445

General Information
Symbol	Dmel\Df(2L)A445	Species	D. melanogaster
Name	Deficiency (2L) Aaron	FlyBase ID	FBab0001414
Feature type	chromosomal_deletion

Computed Breakpoints include	35B1;35B2-35B4
Deleted segment	35B1--35B4
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (McNabb et al., 1996, Fossett et al., 1994)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gubb et al., 1990, Ashburner et al., 1982, McNabb et al., 1996, Roote et al., 1996)
Breakpoints	35B1;35B2 (Ashburner et al., 1982) [];[] (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 hits noc << Adh << bk2 << mol
Genetic mapping information
Comments
Comments on Cytology
	Cytologically invisible deletion. (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996) Limits of break 1 from polytene analysis (FBrf0038050) Left limit of break 2 from inclusion of Adh (FBrf0038050) Right limit of break 2 from non-inclusion of mol (FBrf0038050)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adh (Roote, 2002.1.15, Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8) mol (McNabb et al., 1996) noc (Ashburner et al., 1982, McNabb et al., 1996) osp (Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8)
Partially deleted / disrupted	noc (Fossett et al., 1994, Roote et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ance (Ashburner et al., 1982, Fossett et al., 1994) Arpc1 (Ashburner et al., 1982) b (Ashburner et al., 1982) Ca-α1D (Fossett et al., 1994) ck (Ashburner et al., 1982, Fossett et al., 1994) Cul-3 (Ashburner et al., 1982, Fossett et al., 1994) CycE (Ashburner et al., 1982, Fossett et al., 1994) DNApol-γ35 (Ashburner et al., 1982) dyn-p25 (Ashburner et al., 1982) elA (Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996) elB (Fossett et al., 1994, Roote et al., 1996) esg (Fossett et al., 1994) kuz (Fossett et al., 1994) l(2)34Db (Ashburner et al., 1982, Fossett et al., 1994) l(2)34Fc (Fossett et al., 1994, Ashburner et al., 1982, Roote et al., 1996) l(2)34Fd (Ashburner et al., 1982, Roote et al., 1996) l(2)35Bc (Ashburner et al., 1982) l(2)35Bd (Ashburner et al., 1982) l(2)35Be (Ashburner et al., 1982) l(2)35Bg (Ashburner et al., 1982) l(2)35Cc (Fossett et al., 1994) l(2)35De (Fossett et al., 1994) lace (Ashburner et al., 1982, Fossett et al., 1994) mol (Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996, Roote, 1996.8) mRpL4 (Fossett et al., 1994) ms(2)34Fe (Roote et al., 1996) NimA (Ashburner et al., 1982) NimC3 (Ashburner et al., 1982, Fossett et al., 1994) pburs (Ashburner et al., 1982, Roote et al., 1996) Pgant35A (Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996) rd (Ashburner et al., 1982) rk (Ashburner et al., 1982, Fossett et al., 1994) RpII33 (Ashburner et al., 1982, Fossett et al., 1994) sna (Ashburner et al., 1982, Fossett et al., 1994) Sos (Ashburner et al., 1982) stc (Ashburner et al., 1982, Fossett et al., 1994) Su(H) (Ashburner et al., 1982) tam (Ashburner et al., 1982) TfIIS (Fossett et al., 1994) wb (Ashburner et al., 1982, Fossett et al., 1994) wek (Fossett et al., 1994) wor (Ashburner et al., 1982, Fossett et al., 1994)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Unusual noc complementation data due to function of the two transcripts, nocA and nocB. (Roote et al., 1996) Df(2L)A445 complements mutations in the l(2)35Ba region of noc but does not complement the nocA region of noc. (Fossett et al., 1994)
Phenotypic Data
In combination with other aberrations	Does not suppress the zeste phenotype in a z¹ w^11E4; Tp(1;2)TE35B homologue. (Gubb et al., 1990)
NOT in combination with other aberrations	Chromosome has no effect on the physical interaction between tandemly duplicated copies of w⁺ and z¹, despite having breakpoints within the critical region. (Gubb et al., 1990) Males and females homozygous viable and fertile
Stocks ( 0 )

Notes on Origin
Discoverer	Aaron.
	selected as ADH null on 1-penten-3-ol.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Reported to delete Adhr in error; see FBrf0141768 for correction. (Roote et al., 1996)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	A445 (Fossett et al., 1994) Df(2L)A445
Name Synonym	Deficiency (2L) Aaron
Secondary FlyBase IDs

References ( 9 )
Research paper	McNabb et al., 1996, Genetics 143(2): 897--911 The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. [FBrf0087599] Roote et al., 1996, D. I. S. 77: 55--65 Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422] Fossett et al., 1994, Mutat. Res. 307(1): 213--222 The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. [FBrf0073088] Gubb et al., 1990, Genetics 126: 167--176 A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930] Chia et al., 1985, J. Mol. Biol. 186(2): 689--706 Molecular analysis of the Adh region of the genome of Drosophila melanogaster. [FBrf0043115] Ashburner et al., 1982, Genetics 102: 421--435 The genetics of a small autosomal region of Drosophila melanogaster, including the structural gene for alcohol dehydrogenase. [FBrf0038050]
Personal communication to FlyBase	Roote, 2002.1.15, Adhr status unknown. Adhr status unknown. [FBrf0141768] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]