Aberration Dmel\Df(2R)Drl^rv17

General Information
Symbol	Dmel\Df(2R)Drl^rv17	Species	D. melanogaster
Name		FlyBase ID	FBab0001440
Feature type	chromosomal_deletion
Also Known As	Df(2R)Drl-rv17

Computed Breakpoints include	42C2-42C7;43D1-43D7
Deleted segment	42C2--43D7
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Heitzler et al., 1993, Lo and Frasch, 1998)
Breakpoints	42C2-42C7;43C7 (Heitzler et al., 1993) 42C2-42C7;43D1-43D7 (Lo and Frasch, 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(2)01289 << l(2)43Da << bk2 << l(2)43Db
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0102180) Right limit of break 1 from inclusion of l(2)01289 (FBrf0091336) Left limit of break 2 from inclusion of l(2)43Da (FBrf0058613) Right limit of break 2 from polytene analysis (FBrf0102180)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	cos (Heitzler et al., 1993) dpa (Heitzler et al., 1993) Dscam (Heitzler et al., 1993) hum (Heitzler et al., 1993) l(2)43Ba (Heitzler et al., 1993) l(2)43Bb (Heitzler et al., 1993) l(2)43Bd (Heitzler et al., 1993) l(2)43Cb (Heitzler et al., 1993) l(2)43Cc (Heitzler et al., 1993) l(2)43Da (Heitzler et al., 1993) l(2)01289 (BDGP Project Members, 1994-1999, Roote, 1996.12.3) nec (Heitzler et al., 1993) pk (Heitzler et al., 1993) pwn (Heitzler et al., 1993) so (Heitzler et al., 1993) Tdc1 (Cole et al., 2005) Tdc2 (Cole et al., 2005) vimar (Lo and Frasch, 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Bap170 (Rendina et al., 2010) blow (Heitzler et al., 1993) boca (Heitzler et al., 1993) cn (Heitzler et al., 1993) fs(2)43Ei (Heitzler et al., 1993) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) l(2)43Db (Heitzler et al., 1993) l(2)43Ef (Heitzler et al., 1993) l(2)43Eg (Heitzler et al., 1993) l(2)43Eh (Heitzler et al., 1993) Rpt1 (Heitzler et al., 1993) scra (Heitzler et al., 1993) tor (Heitzler et al., 1993) U2A (Heitzler et al., 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Semi-lethality of the vimar^B6-2-30 mutation is complemented in combination with Df(2R)Drl^rv17. (Lo and Frasch, 1998)
Stocks ( 3 )
Bloomington	4313 Df(2R)Drl^rv17/CyO
Kyoto	107684 Df(2R)Drl^rv17/CyO 101440 Df(2R)Drl^rv17 / CyO, Cy¹ dp^lv1 pr¹ cn²
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)Drl^rv17 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)Drl^rv17 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2R)Drl^rv17 (Rendina et al., 2010) Df(2R)Drl-R+17 Df(2R)Drl-rv17 (Mason et al., 2004, Heitzler et al., 1993)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Cole et al., 2005, J. Biol. Chem. 280(15): 14948--14955 Two functional but noncomplementing Drosophila tyrosine decarboxylase genes. [FBrf0187786] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Lo and Frasch, 1998, Mech. Dev. 72(1,2): 65--75 bagpipe-dependent expression of vimar, a novel armadillo-repeats gene, in Drosophila visceral mesoderm. [FBrf0102180] Heitzler et al., 1993, Genetics 135(1): 105--115 Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster. [FBrf0058613]
Supplementary material	Rendina et al., 2010, Genetics 186(1): Supporting Information. [FBrf0212743]
Personal communication to FlyBase	Roote and Ashburner, 2005.6, l(2)43A mutations. l(2)43A mutations. [FBrf0188639] Roote, 1996.12.3, PZ01289 and PZ04524. PZ01289 and PZ04524. [FBrf0091336] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]

Aberration Dmel\Df(2R)Drlrv17

Aberration Dmel\Df(2R)Drl^rv17