FlyBase Aberration Report: Dmel\Df(2L)E55

General Information

Symbol

Df(2L)E55

Species

D. melanogaster

Name

FlyBase ID

FBab0001458

Feature type

chromosomal_deletion

Computed Breakpoints include

37D2;38A1

Deleted Segment

37D2--38A1

Sequence coordinates

2L:19,691,199..19,701,224 [+] (Df(2L)E55:bk2)

(Krueger et al., 1996)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

ethyl methanesulfonate

(Stathakis et al., 1995, Wright et al., 1981, Wright et al., 1976)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Stathakis et al., 1995, Pentz et al., 1990, Wright et al., 1981, Wright et al., 1976)

Breakpoints

37D2-37E1;37F5-38A1

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Pentz et al., 1990, Wright et al., 1976)

37D2-37E1;35F5-38A1

(Wright et al., 1981)

37C6-37D1;37F5-38A1

(Stathakis et al., 1995)

Causes alleles

Lar^E55

(Wills et al., 1999, Desai et al., 1997, Krueger et al., 1996)

Carries alleles

Transposon Insertions

Formalized genetic data

γTub37C << bk1 << l(2)37Da << fs(2)lto3 << bk2 << Lar

Genetic mapping information

Comments

Breakpoint(s) molecularly mapped

(Rutledge et al., 1992)

Comments on Cytology

Ref: FBrf0028752.

(Stathakis et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0028752) Right limit of break 1 from inclusion of l(2)37Da (citation unavailable) Left limit of break 2 from inclusion of Lar (FBrf0086508) Right limit of break 2 from polytene analysis (FBrf0028752)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Acn

(Stathakis et al., 1995)

amd

(Stathakis et al., 1995, Wright et al., 1976)

amos

(Wright et al., 1976)

AsnRS

(Stathakis et al., 1995)

(Wright et al., 1976)

brat

(Stathakis et al., 1995, Brittnacher and Ganetzky, 1983)

CadN

(Wright et al., 1976)

Catsup

(Stathakis et al., 1995)

crc

(Wright et al., 1976)

cub

(Stathakis et al., 1995)

DCTN6-p27

(Stathakis et al., 1995)

Ddc

(Stathakis et al., 1995, Wright et al., 1976)

esc

(Wright et al., 1976)

Fs(2)Ket

(Butler et al., 2001)

fs(2)ltoPP43

(Butler et al., 2001)

hook

(Stathakis et al., 1995, Wright et al., 1976)

l(2)37Bb

(Stathakis et al., 1995)

l(2)37Cb

(Stathakis et al., 1995)

l(2)37Cc

(Stathakis et al., 1995)

l(2)37Cd

(Stathakis et al., 1995)

l(2)37Cg

(Stathakis et al., 1995)

l(2)37Fe

(Jones and McGinnis, 1993)

l(2)37Fg

(Jones and McGinnis, 1993)

Lim3

(Stathakis et al., 1995)

Low

(Bhadra et al., 1997)

(Wright et al., 1976)

M(2)39F

(Wright et al., 1976)

mib2

(Stathakis et al., 1995)

neb

(Ohkura et al., 1997)

(Wright et al., 1976)

rdo

(Wright et al., 1976)

Rpn3

(Stathakis et al., 1995)

RpS26

(Wright et al., 1976)

scw

(Jones and McGinnis, 1993, Tearle and Nusslein-Volhard, 1987)

tyr1

(Pentz et al., 1990)

γTub37C

(Stathakis et al., 1995)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Related Comments

Phenotypic Data

In combination with other aberrations

Fails to complement Df(2L)Exel9043.

(Bloomington Drosophila Stock Center, 2005.2.3)

The width of the CNS is closer to wild-type in Df(2L)E55 ; Df(3L)H99 double mutant embryos than in Df(2L)E55 single mutant embryos, although commissure separation remains incomplete.

(Dong and Jacobs, 1997)

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

Lethal over Df(2L)TW9 and Df(2L)TW158.

(Wright et al., 1976)

Df(2L)E55/Df(2L)TW330 lethal Df(2L)E55/Df(2L)VA15 lethal Df(2L)E55/Df(2L)VA20 lethal Df(2L)E55/Df(2L)VA22 lethal Df(2L)E55/Df(2L)VA23 lethal Df(2L)E55/Df(2L)VA25 lethal Df(2L)E55/Df(2L)TW9 lethal Df(2L)E55/Df(2L)TW12 lethal Df(2L)E55/Df(2L)TW150 viable Df(2L)E55/Df(2L)TW84 viable Df(2L)E55/Df(2L)OD16 viable Df(2L)E55/Df(2L)TW150 non-transparent wing phenotype Df(2L)E55/Df(2L)TW84 non-transparent wing phenotype Df(2L)E55/Df(2L)OD16 non-transparent wing phenotype

NOT in combination with other aberrations

Heterozygosity for Df(2L)E55 results in 3.5% X chromosome nondisjunction and 2.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

The central nervous system (CNS) is narrower than normal and the commissures are thicker than normal and incompletely separated in Df(2L)E55 embryos.

(Dong and Jacobs, 1997)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Homozygous embryos do not always complete head involution.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (3)

Bloomington

3076

Df(2L)E55, rdo¹ hook¹ Lar^E55 pr¹/CyO

Kyoto

106822

Df(2L)E55, rdo¹ hook¹ Lar^E55 pr¹/CyO

103230

CyO, Duox^Cy dpy^lv1 pr¹ cn² / Df(2L)E55, rdo¹ hook¹ pr¹

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2L)E55 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

(Mason et al., 2004)

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(2L)E55

(Agrawal and Hardin, 2016, Gunawan et al., 2013, Casso et al., 2008, Carre-Mlouka et al., 2007, Crest et al., 2007, Kamimura et al., 2006)

Df(2L)TWE55

(Wyers et al., 1995)

Df(3L)E55

(Wills et al., 1999)

E55

(Brittnacher and Ganetzky, 1983)

Name Synonyms

Secondary FlyBase IDs

References (46)

Report Sections

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