Aberration Dmel\Df(2L)E55

General Information
Symbol	Dmel\Df(2L)E55	Species	D. melanogaster
Name		FlyBase ID	FBab0001458
Feature type	chromosomal_deletion

Computed Breakpoints include	37D2;38A1
Deleted segment	37D2--38A1
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	2L:19,691,199..19,701,224 [+] (Df(2L)E55:bk2) (Krueger et al., 1996)
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	ethyl methanesulfonate (Wright et al., 1976, Wright et al., 1981, Stathakis et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Wright et al., 1976, Wright et al., 1981, Pauli et al., 1995, Stathakis et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pentz et al., 1990)
Breakpoints	37C6-37D1;37F5-38A1 (Stathakis et al., 1995) 37D2-37E1;35F5-38A1 (Wright et al., 1981) 37D2-37E1;37F5-38A1 (Wright et al., 1976, Pentz et al., 1990, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996)
Causes alleles	Lar^E55 (Wills et al., 1999, Desai et al., 1997, Krueger et al., 1996)
Carries alleles
Transposon Insertions
Formalized genetic data	γTub37C << bk1 << l(2)37Da << fs(2)lto3 << bk2 << Lar
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Rutledge et al., 1992)
Comments on Cytology
	Ref: FBrf0028752. (Stathakis et al., 1995) Left limit of break 1 from polytene analysis (FBrf0028752) Right limit of break 1 from inclusion of l(2)37Da (citation unavailable) Left limit of break 2 from inclusion of Lar (FBrf0086508) Right limit of break 2 from polytene analysis (FBrf0028752)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	fs(2)lto3 (Schupbach and Wieschaus, 1991) fs(2)ltoRV64 (Schupbach and Wieschaus, 1991) l(2)37Db (Brittnacher and Ganetzky, 1983) l(2)37Dc (Brittnacher and Ganetzky, 1983) l(2)37De (Brittnacher and Ganetzky, 1983) l(2)37Di (Brittnacher and Ganetzky, 1983) l(2)37Ea (Butler et al., 2001) l(2)37Fc (Butler et al., 2001) Lar (Krueger et al., 1996, Desai et al., 1997) RanGAP (Brittnacher and Ganetzky, 1983) ref(2)P (Wyers et al., 1995) spi (Tearle and Nusslein-Volhard, 1987, Jones and McGinnis, 1993, BDGP Project Members, 1994-1999, Tio et al., 1994, Harbecke and Lengyel, 1995) swm (Brittnacher and Ganetzky, 1983, Gay and Contamine, 1993) tj (Li et al., 2003)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Aats-asn (Stathakis et al., 1995) Acn (Stathakis et al., 1995) amd (Wright et al., 1976, Stathakis et al., 1995) amos (Wright et al., 1976) Bl (Wright et al., 1976) brat (Brittnacher and Ganetzky, 1983, Stathakis et al., 1995) CadN (Wright et al., 1976) Catsup (Stathakis et al., 1995) crc (Wright et al., 1976) cub (Stathakis et al., 1995) Ddc (Wright et al., 1976, Stathakis et al., 1995) esc (Wright et al., 1976) Fs(2)Ket (Butler et al., 2001) fs(2)ltoPP43 (Butler et al., 2001) hk (Wright et al., 1976, Stathakis et al., 1995) l(2)37Bb (Stathakis et al., 1995) l(2)37Cb (Stathakis et al., 1995) l(2)37Cc (Stathakis et al., 1995) l(2)37Cd (Stathakis et al., 1995) l(2)37Ce (Stathakis et al., 1995) l(2)37Cg (Stathakis et al., 1995) l(2)37Fe (Jones and McGinnis, 1993) l(2)37Fg (Jones and McGinnis, 1993) Lim3 (Stathakis et al., 1995) Low (Bhadra et al., 1997) lt (Wright et al., 1976) M(2)39F (Wright et al., 1976) mib2 (Stathakis et al., 1995) neb (Ohkura et al., 1997) pr (Wright et al., 1976) rdo (Wright et al., 1976) Rpn3 (Stathakis et al., 1995) RpS26 (Wright et al., 1976) scw (Tearle and Nusslein-Volhard, 1987, Jones and McGinnis, 1993) tyr1 (Pentz et al., 1990) γTub37C (Stathakis et al., 1995)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement Df(2L)Exel9043. (Bloomington Drosophila Stock Center, 2005.2.3) The width of the CNS is closer to wild-type in Df(2L)E55 ; Df(3L)H99 double mutant embryos than in Df(2L)E55 single mutant embryos, although commissure separation remains incomplete. (Dong and Jacobs, 1997) No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989) Lethal over Df(2L)TW9 and Df(2L)TW158. (Wright et al., 1976) Df(2L)E55/Df(2L)TW330 lethal Df(2L)E55/Df(2L)VA15 lethal Df(2L)E55/Df(2L)VA20 lethal Df(2L)E55/Df(2L)VA22 lethal Df(2L)E55/Df(2L)VA23 lethal Df(2L)E55/Df(2L)VA25 lethal Df(2L)E55/Df(2L)TW9 lethal Df(2L)E55/Df(2L)TW12 lethal Df(2L)E55/Df(2L)TW150 viable Df(2L)E55/Df(2L)TW84 viable Df(2L)E55/Df(2L)OD16 viable Df(2L)E55/Df(2L)TW150 non-transparent wing phenotype Df(2L)E55/Df(2L)TW84 non-transparent wing phenotype Df(2L)E55/Df(2L)OD16 non-transparent wing phenotype
NOT in combination with other aberrations	Heterozygosity for Df(2L)E55 results in 3.5% X chromosome nondisjunction and 2.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The central nervous system (CNS) is narrower than normal and the commissures are thicker than normal and incompletely separated in Df(2L)E55 embryos. (Dong and Jacobs, 1997) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Homozygous embryos do not always complete head involution. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 3 )
Bloomington	3076 Df(2L)E55, rdo¹ hk¹ Lar^E55 pr¹/CyO
Kyoto	106822 Df(2L)E55, rdo¹ hk¹ Lar^E55 pr¹/CyO 103230 CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2L)E55, rdo¹ hk¹ pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)E55 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)E55 (Crest et al., 2007, Kamimura et al., 2006, Carre-Mlouka et al., 2007, Casso et al., 2008) Df(2L)TWE55 (Wyers et al., 1995) Df(3L)E55 (Wills et al., 1999) E55 (Brittnacher and Ganetzky, 1983)
Name Synonym
Secondary FlyBase IDs

References ( 44 )

Generate a list of	All references relating to this aberration ( 44 )

List References by type	Research paper ( 39 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Aberration Dmel\Df(2L)E55

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