FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2L)Gpdh1-A
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General Information
Symbol
Df(2L)Gpdh1-A
Species
D. melanogaster
Name
FlyBase ID
FBab0001468
Feature type
chromosomal_deletion
Also Known As
Df(2L)GdhA, Df(2L)GpdHA, Df(2L)gdh-A
Computed Breakpoints include

25D7;26A8-26A9

Features within 25D7--26A9
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Knipple and MacIntyre, 1984, Kotarski et al., 1983)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Aguade, 1998, Basu and Li, 1998, Giansanti et al., 1998, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, de Belle et al., 1989, Locke et al., 1988, Knipple and MacIntyre, 1984, Racine et al., 1980)
Breakpoints

25E2-25E4;26B3-26B9

(Racine et al., 1980)

25E1-25E2;26A8-26A9

(Knipple and MacIntyre, 1984)

25D7;26A8-26A9

(Aguade, 1998, Locke et al., 1988)

25D7-25E1;26A8-26A9

(Basu and Li, 1998, Giansanti et al., 1998, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, de Belle et al., 1989)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

cype << bk1 << l(2)25Ea << l(2)26Ad << bk2 << l(2)26Cf

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Knipple et al., 1991)
Comments on Cytology

H2.0 maps (by in situ hybridisation) to the right of the Df(2L)GpdhA deficiency.

(Barad et al., 1988)

Limits of break 1 from polytene analysis (FBrf0048198) Left limit of break 2 from inclusion of lid (FBrf0067338) Right limit of break 2 from polytene analysis (FBrf0041503)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Acp26Aa
(Aguade, 1998)
Acp26Ab
(Aguade, 1998)
chic
(Spradling et al., 1999, Wills et al., 1999, Giansanti et al., 1998, BDGP Project Members, 1994-1999, Castrillon et al., 1993)
cl
(Kotarski et al., 1983)
E(var)26A
(Locke et al., 1988)
eIF4A
(Li et al., 2005, Spradling et al., 1999, Beaton, 1997.3.4, BDGP Project Members, 1994-1999, Dorn et al., 1993, Kotarski et al., 1983)
Gal
(Knipple and MacIntyre, 1984)
Gpdh1
(Kotarski et al., 1983, Racine et al., 1980)
H15
(Miskolczi-McCallum et al., 2005)
Hel25E
(Kotarski et al., 1983)
ifc
(Spradling et al., 1999, Basu and Li, 1998, BDGP Project Members, 1994-1999, Castrillon et al., 1993, Kotarski et al., 1983)
Kdm5
(Gildea et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)25Ea
(Kotarski et al., 1983)
l(2)25Ed
(Kotarski et al., 1983)
l(2)25Ee
(Kotarski et al., 1983)
l(2)25Ef
(Kotarski et al., 1983)
l(2)25Eg
(Kotarski et al., 1983)
l(2)25Fa
(Kotarski et al., 1983)
l(2)25Fb
(Kotarski et al., 1983)
l(2)25Fc
(Kotarski et al., 1983)
l(2)25Fd
(Kotarski et al., 1983)
l(2)25Fe
(Kotarski et al., 1983)
l(2)26Ad
(Kotarski et al., 1983)
l(2)26Ae
(Kotarski et al., 1983)
l(2)k06502
(BDGP Project Members, 1994-1999)
l(2)k07109a
(BDGP Project Members, 1994-1999)
l(2)PN-6
(Racine et al., 1980)
l(2)PN-11
(Racine et al., 1980)
Lam
(Osouda et al., 2005, Guillemin et al., 2001, Spradling et al., 1999, Guillemin, 1997.6.19, BDGP Project Members, 1994-1999, Kotarski et al., 1983)
lncRNA:CR31647
(Miskolczi-McCallum et al., 2005)
mid
(Kumar et al., 2015, Miskolczi-McCallum et al., 2005, Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987)
milt
(BDGP Project Members, 1994-1999)
tkv
(Harbecke and Lengyel, 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
H15
(Buescher et al., 2004)
lncRNA:CR31647
(Buescher et al., 2004)
mid
(Buescher et al., 2004)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Df(2L)x528/Df(2L)Gpdh1-A is embryonic lethal and impacts founder cells for lateral transverse muscle 3, lateral transverse muscle 4, lateral oblique muscle 1 and ventral transverse muscle 1; loss of lateral transverse muscles.

    (Kumar et al., 2015)

    Df(2L)x528/Df(2L)Gpdh1-A embryos show a loss of neuroblasts NB1-1, NB2-5 and NB2-4. This loss is much more pronounced in odd-numbered than even-numbered abdominal segments. However, the loss is similar to mid mutants, suggesting that the it is deletion of the mid gene and not the H15 gene that is causing the phenotype.

    (Buescher et al., 2006)

    Inferred to overlap with: Df(2L)x528.

    (Miskolczi-McCallum et al., 2005)

    Df(2L)Gpdh1-A/Df(2L)x528 larvae show a loss of denticle belts; denticle rows 1 to 5 are frequently lost in odd-numbered segments, whereas even-numbered segments show milder defects. Df(2L)H15-x4/Df(2L)Gpdh1-A larvae show a weak loss of denticles phenotype.

    (Buescher et al., 2004)

    Enhances position effect variegation at the w locus caused by In(1)wm4, C(1;YL)wmMc or T(1;4)wm5 and position effect variegation at the y locus caused by In(1)y3P.

    (Locke et al., 1988)

    Lethal in combination with Df(2L)cl7. Lethal in combination with Df(2L)Gpdh1-78. Lethal in combination with Df(2L)Gpdh1-75. Lethal in combination with Df(2L)cl1. Lethal in combination with Df(2L)cl2.

    (Racine et al., 1980)
    NOT in combination with other aberrations

    Heterozygosity for Df(2L)Gpdh1-A results in 8.0% X chromosome nondisjunction and 2.2% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)

    Homozygous embryos are very abnormal compared to wild-type. The hindgut is short and broad, and the Malpighian tubules do not elongate.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Enhance mottling in wm4.

    (Tartof et al., 1989)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (15)
    References (62)