A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(2L)GpdhA

General Information
SymbolDmel\Df(2L)GpdhASpeciesD. melanogaster
NameFlyBase IDFBab0001468
Feature typechromosomal_deletion
Also Known AsDf(2L)GdhA, Df(2L)gdh-A
Computed Breakpoints include 25D7;26A8-26A9
Deleted segment25D7--26A9
Sequence coordinates
Member of large scale dataset(s)
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Description
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FB2013_03
FB2013_02
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Kotarski et al., 1983, Knipple and MacIntyre, 1984)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Pauli et al., 1995, de Belle et al., 1989, Duffy et al., 1996, Knipple and MacIntyre, 1984, Harbecke and Lengyel, 1995, Giansanti et al., 1998, Locke et al., 1988, Aguade, 1998, Basu and Li, 1998, Racine et al., 1980)
Breakpoints
25D7-25E1;26A8-26A9
(de Belle et al., 1989, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Giansanti et al., 1998, Basu and Li, 1998)
25D7;26A8-26A9
(Locke et al., 1988, Aguade, 1998)
25E1-25E2;26A8-26A9
(Knipple and MacIntyre, 1984)
25E2-25E4;26B3-26B9
(Racine et al., 1980)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data cype << bk1 << l(2)25Ea << l(2)26Ad << bk2 << l(2)26Cf
Genetic mapping information
Comments
Breakpoint(s) molecularly mapped
(Knipple et al., 1991)
hide Comments on Cytology
H2.0 maps (by in situ hybridisation) to the right of the Df(2L)GpdhA deficiency.
(Barad et al., 1988)
Limits of break 1 from polytene analysis (FBrf0048198) Left limit of break 2 from inclusion of lid (FBrf0067338) Right limit of break 2 from polytene analysis (FBrf0041503)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Acp26Aa
(Aguade, 1998)
Acp26Ab
(Aguade, 1998)
chic
(Giansanti et al., 1998, Wills et al., 1999, Spradling et al., 1999, Castrillon et al., 1993, BDGP Project Members, 1994-1999)
cl
(Kotarski et al., 1983)
CR31647
(Miskolczi-McCallum et al., 2005)
E(var)26A
(Locke et al., 1988)
eIF-4a
(Spradling et al., 1999, Li et al., 2005, Kotarski et al., 1983, Dorn et al., 1993, BDGP Project Members, 1994-1999, Beaton, 1997.3.4)
Gal
(Knipple and MacIntyre, 1984)
Gpdh
(Racine et al., 1980, Kotarski et al., 1983)
H15
(Miskolczi-McCallum et al., 2005)
Hel25E
(Kotarski et al., 1983)
ifc
(Basu and Li, 1998, Spradling et al., 1999, Kotarski et al., 1983, Castrillon et al., 1993, BDGP Project Members, 1994-1999)
l(2)25Ea
(Kotarski et al., 1983)
l(2)25Ed
(Kotarski et al., 1983)
l(2)25Ee
(Kotarski et al., 1983)
l(2)25Ef
(Kotarski et al., 1983)
l(2)25Eg
(Kotarski et al., 1983)
l(2)25Fa
(Kotarski et al., 1983)
l(2)25Fb
(Kotarski et al., 1983)
l(2)25Fc
(Kotarski et al., 1983)
l(2)25Fd
(Kotarski et al., 1983)
l(2)25Fe
(Kotarski et al., 1983)
l(2)26Ad
(Kotarski et al., 1983)
l(2)26Ae
(Kotarski et al., 1983)
l(2)k06502
(BDGP Project Members, 1994-1999)
l(2)k07109a
(BDGP Project Members, 1994-1999)
l(2)PN-6
(Racine et al., 1980)
l(2)PN-11
(Racine et al., 1980)
Lam
(Spradling et al., 1999, Guillemin et al., 2001, Osouda et al., 2005, Kotarski et al., 1983, BDGP Project Members, 1994-1999, Guillemin, 1997.6.19)
lid
(Spradling et al., 1999, Gildea et al., 2000, BDGP Project Members, 1994-1999)
mid
(Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987, Miskolczi-McCallum et al., 2005)
milt
(BDGP Project Members, 1994-1999)
tkv
(Harbecke and Lengyel, 1995)
Molecular Data
Completely deleted
CR31647
(Buescher et al., 2004)
H15
(Buescher et al., 2004)
mid
(Buescher et al., 2004)
hide Genes NOT Deleted / Disrupted
Complementation Data
cype
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
dp
(Kotarski et al., 1983)
for
(de Belle et al., 1989)
Kr-h1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)26Cf
(Kotarski et al., 1983)
l(2)04884
(BDGP Project Members, 1994-1999)
l(2)k04909b
(BDGP Project Members, 1994-1999)
qua
(Bloomington Drosophila Stock Center, 1998.9.22)
RpL37A
(Kotarski et al., 1983)
tkv
(Kotarski et al., 1983)
vri
(BDGP Project Members, 1994-1999)
wg
(Kotarski et al., 1983)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Df(2L)x528/Df(2L)GpdhA embryos show a loss of neuroblasts NB1-1, NB2-5 and NB2-4. This loss is much more pronounced in odd-numbered than even-numbered abdominal segments. However, the loss is similar to mid mutants, suggesting that the it is deletion of the mid gene and not the H15 gene that is causing the phenotype.
(Buescher et al., 2006)
Inferred to overlap with: Df(2L)x528.
(Miskolczi-McCallum et al., 2005)
Df(2L)GpdhA/Df(2L)x528 larvae show a loss of denticle belts; denticle rows 1 to 5 are frequently lost in odd-numbered segments, whereas even-numbered segments show milder defects. Df(2L)H15-x4/Df(2L)GpdhA larvae show a weak loss of denticles phenotype.
(Buescher et al., 2004)
Enhances position effect variegation at the w locus caused by In(1)wm4, C(1;YL)wmMc or T(1;4)wm5 and position effect variegation at the y locus caused by In(1)y3P.
(Locke et al., 1988)
Lethal in combination with Df(2L)cl7. Lethal in combination with Df(2L)Gpdh78. Lethal in combination with Df(2L)Gpdh75. Lethal in combination with Df(2L)cl1. Lethal in combination with Df(2L)cl2.
(Racine et al., 1980)
NOT in combination with other aberrations
Heterozygosity for Df(2L)GpdhA results in 8.0% X chromosome nondisjunction and 2.2% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
(Harris et al., 2003)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
Dominantly causes tergite defects in less than 50% of run3 heterozygotes.
(Duffy et al., 1996)
Midgut development of mutant embryos is wild type.
(Bilder and Scott, 1995)
Homozygous embryos are very abnormal compared to wild-type. The hindgut is short and broad, and the Malpighian tubules do not elongate.
(Harbecke and Lengyel, 1995)
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Enhance mottling in wm4.
(Tartof et al., 1989)
hide Stocks ( 2 )
Bloomington
1128
Df(2L)GpdhA/CyO, P{sevRas1.V12}FK1
Kyoto
106215
Df(2L)GpdhA/CyO
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
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hide Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym
Df(2)GdhA
(Verheyen and Cooley, 1994)
Df(2)GpdhA
(Gonçalves-Pimentel et al., 2011)
Df(2L)GdhA
(Wilanowski et al., 1998)
Df(2L)gdh-A
(Osouda et al., 2005)
Df(2L)Gdh-A
(Abrell et al., 2000)
Df(2L)GdhA
(Bewley, 1981, Locke et al., 1988, Tearle and Nusslein-Volhard, 1987, Bewley, 1983, Knipple and MacIntyre, 1984, de Belle et al., 1989, Kotarski et al., 1983, Dorn et al., 1993, Symonds and Gibson, 1992, Tartof et al., 1989, Bartoszewski and Gibson, 1998)
Df(2L)Gdh-A,dpL
(Aguade, 1998)
Df(2L)GpdhA
(Gibson et al., 1990)
Df(2L)GpdhA
(Crest et al., 2007, Casso et al., 2008)
Df(2L)GpdHA
(Buescher et al., 2006)
Df(chic)
(Gonçalves-Pimentel et al., 2011)
Df-GpdhA
(Buescher et al., 2004)
GpdhA
(Yamaguchi et al., 2001)
Name Synonym
GdhA deficiency
(Barad et al., 1988)
Secondary FlyBase IDs
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hide Recent research papers ( 1 )
Gonçalves-Pimentel et al., 2011, PLoS ONE 6(3): e18340
Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [FBrf0213367]
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