FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2L)H20
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General Information
Symbol
Df(2L)H20
Species
D. melanogaster
Name
FlyBase ID
FBab0001470
Feature type
chromosomal_deletion
Also Known As
Df(2L)H2, Df(2)H20, H20
Computed Breakpoints include

36A8-36A9;36F1

Features within 36A8--36F1
Genomic Maps
Sequence coordinates
2L:16,686,357..16,689,573 [+] (Df(2L)H20:bk1)
(Li and Baker, 1998)
2L:16,680,000..16,692,000 (Df(2L)H20:bk1)
(Cook, 2016.2.8)
2L:18,359,026..18,393,441 (Df(2L)H20:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Steward and Nusslein-Volhard, 1986, Simpson, 1983)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Duffy et al., 1996, Fitzpatrick et al., 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Pultz et al., 1994, Homyk and Emerson, 1988, Steward and Nusslein-Volhard, 1986, Whalen and Wilson, 1986, Simpson, 1983)
Breakpoints

36A12-36A14;36E1-36E2

(Simpson, 1983)

36A6-36A10;36E3-36F2

(Steward and Nusslein-Volhard, 1986)

36A8-36A9;36E3-36E4

(Fitzpatrick et al., 1995, Landecker et al., 1994, Whalen and Wilson, 1986)

36A6-36A7;36F1-36F2

(Homyk and Emerson, 1988)

36A8-36A9;36E1-36E2

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Schupbach and Wieschaus, 1989)

36A6-36A11;36E3-36F2

(Pultz et al., 1994)
Causes alleles
Fas3H20
(Marygold, 2005.1.19)
Carries alleles
Transposon Insertions
Formalized genetic data

her << bk1 << l(2)k04206 << bk2 << Dox-A3

Genetic mapping information
Comments

The 2L:16680054..16692000 release 6 coordinates of the left breakpoint are estimates based on figure 2 of FBrf0100594.

(Cook, 2016.2.8)

The 2L:18359026..18393441 release 6 coordinates of the right breakpoint are estimates based on FBrf0183166, which showed the breakpoint to map between the right end of Acp36DE and the right end of Fas3.

(Cook, 2016.2.8)

Breakpoint 1 was mapped to an EcoRI-HpaI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Li and Baker, 1998)
Comments on Cytology

Ref: Ashburner et al., 1990, Genetics 126: 679--694

(Pultz et al., 1994)

Ref: FBrf0045239.

(Homyk and Emerson, 1988)

Limits of break 1 from polytene analysis (FBrf0044474) Left limit of break 2 from polytene analysis (FBrf0048188) Right limit of break 2 from polytene analysis (FBrf0044468)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
AcpC
(Whalen and Wilson, 1986)
BicD
(Schupbach and Wieschaus, 1991, Steward and Nusslein-Volhard, 1986)
bst
(Boquet et al., 2000)
CadN
(Brumby et al., 2004, Steward and Nusslein-Volhard, 1986)
cass
(Morris et al., 2006, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Cse1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Cyt-c-d
(Castrillon et al., 1993)
Cyt-c-p
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
dl
(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989, Steward and Nusslein-Volhard, 1986)
Dox-3
(Rizki et al., 1985)
E(var)36AE
(Wustmann et al., 1989)
fs(2)ltoHC44
(Schupbach and Wieschaus, 1991)
glu
(Spradling et al., 1999, Kania et al., 1995, BDGP Project Members, 1994-1999)
grp
(Spradling et al., 1999, Li and Baker, 1998, BDGP Project Members, 1994-1999)
kel
(Schupbach and Wieschaus, 1991, Steward and Nusslein-Volhard, 1986)
l(2)36Aa
(Ashburner et al., 1990, Steward and Nusslein-Volhard, 1986)
l(2)36Ab
(Ashburner et al., 1990, Steward and Nusslein-Volhard, 1986)
l(2)36Ac
(Ashburner et al., 1990, Steward and Nusslein-Volhard, 1986)
l(2)36Ad
(Ashburner et al., 1990, Steward and Nusslein-Volhard, 1986)
l(2)36Ba
(Steward and Nusslein-Volhard, 1986)
l(2)36Bb
(Steward and Nusslein-Volhard, 1986)
l(2)36Bc
(Steward and Nusslein-Volhard, 1986)
l(2)36Bd
(Steward and Nusslein-Volhard, 1986)
l(2)36Ca
(Steward and Nusslein-Volhard, 1986)
l(2)k04206
(Roote, 1998.11.16)
mdy
(Schupbach and Wieschaus, 1991)
Mhc
(Bosch and Perrimon, 2019.9.30, Babu and Ramachandra, 2007, Montana and Littleton, 2004, Nongthomba et al., 2003, Kronert et al., 1999, Nongthomba and Ramachandra, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999, Cripps et al., 1994, Homyk and Emerson, 1988, Steward and Nusslein-Volhard, 1986)
ninaD
(Steward and Nusslein-Volhard, 1986)
plo
(Ashburner et al., 1990, Steward and Nusslein-Volhard, 1986)
Ptp36E
(Fitzpatrick et al., 1995)
qua
(Schupbach and Wieschaus, 1991, Steward and Nusslein-Volhard, 1986)
rdgI
(Colley, 2016.6.20)
rdo
(Steward and Nusslein-Volhard, 1986)
Partially deleted / disrupted
Molecular Data
Completely deleted
Acp36DE
(Marygold, 2005.1.19)
Partially deleted
Fas3
(Marygold, 2005.1.19)
Genes NOT Deleted / Disrupted
Complementation Data
 
BicC
(Ashburner et al., 1990)
bun
(BDGP Project Members, 1994-1999)
cact
(Ashburner et al., 1990, Tearle and Nusslein-Volhard, 1987)
Ca-α1D
(Ashburner et al., 1990)
chif
(Ashburner et al., 1990)
ck
(Ashburner et al., 1990)
cni
(Ashburner et al., 1990)
crp
(Ashburner et al., 1990)
Cul3
(Ashburner et al., 1990)
CycE
(Ashburner et al., 1990)
Cyp303a1
(Ashburner et al., 1990)
dac
(Ashburner et al., 1990)
esg
(Ashburner et al., 1990)
fzy
(Ashburner et al., 1990)
Gli
(Ashburner et al., 1990)
heix
(Ashburner et al., 1990)
her
(Li and Baker, 1998, Pultz et al., 1994)
l(2)35De
(Ashburner et al., 1990)
l(2)k07020
(BDGP Project Members, 1994-1999)
l(2)k09927
(BDGP Project Members, 1994-1999)
l(2)k10816
(BDGP Project Members, 1994-1999)
l(2)k17039
(BDGP Project Members, 1994-1999)
lace
(Ashburner et al., 1990)
mRpL4
(Ashburner et al., 1990)
ms(2)35Eb
(Ashburner et al., 1990)
Mtr4
(Ashburner et al., 1990)
nAChRα6
(Watson et al., 2010)
ncm
(Coelho et al., 2005, Marygold, 2005.1.19)
ND-B17
(Ashburner et al., 1990)
PolD3
(Ashburner et al., 1990)
RpS26
(Marygold, 2005.1.19, Spradling et al., 1999, BDGP Project Members, 1994-1999, Rizki et al., 1985)
sna
(Ashburner et al., 1990)
stc
(Ashburner et al., 1990)
Su(H)
(Ashburner et al., 1990)
Syx5
(Ashburner et al., 1990)
TfIIS
(Ashburner et al., 1990)
Uxt
(Ashburner et al., 1990)
vas
(Ashburner et al., 1990)
wek
(Ashburner et al., 1990)
wor
(Ashburner et al., 1990)
Molecular Data
 
bsf
(Marygold, 2005.1.19)
CG10211
(Marygold, 2005.1.19)
CG10283
(Marygold, 2005.1.19)
CG31749
(Marygold, 2005.1.19)
grnd
(Marygold, 2005.1.19)
kon
(Marygold, 2005.1.19)
ncm
(Marygold, 2005.1.19)
Pde11
(Marygold, 2005.1.19)
RpS26
(Marygold, 2005.1.19)
Ugt301D1
(Marygold, 2005.1.19)
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Df(2L)M36F-S6 is semi-lethal in combination with Df(2L)H20. Surviving males and females are fertile.

    (Levine et al., 2007)

    Df(2L)RA5/Df(2L)H20 females have reduced fertility.

    (Levine et al., 2007)

    Df(2L)r10/Df(2L)H20 results in almost complete lethality.

    (Levine et al., 2007)

    Inferred to overlap with: Df(2L)TW137.

    (Marygold, 2005.1.19)

    Effect on variegation of y in In(1)y3P and Sb in T(2;3)SbV studied: inactivation of y occurs independently of inactivation of Sb.

    (Bishop, 1992)

    Enhancer of In(1)wm4h position-effect variegation.

    (Wustmann et al., 1989)

    Df(2L)H20/Df(2L)TW119 lethal Df(2L)H20/Df(2L)M36F-S5 lethal Df(2L)H20/Df(2L)TW137 lethal Df(2L)H20/Df(2L)T317 lethal Df(2L)H20/Df(2L)TW201 lethal Df(2L)H20/Df(2L)203 lethal Df(2L)H20/Df(2L)330 lethal Df(2L)H20/Df(2L)VA18 lethal

    NOT in combination with other aberrations

    Lysates from 4 hour old prepupae heterozygous for Df(2L)H20 show no reduction in caspase activation compared to wild type.

    (Dorstyn et al., 2004)

    The Df(2L)H20 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(2L)H20 results in 2.8% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Heterozygotes show no adult central brain defect.

    (Boquet et al., 2000)

    Df(2L)H20 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile.

    (Sawamura et al., 2000)

    Heterozygotes are flightless, but show normal muscle patterns, except for a reduced birefringence of the indirect flight muscles compared to those of wild type.

    (Nongthomba and Ramachandra, 1999)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    Intermediate second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance 25-75%.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)

    Homozygous embryos have a truncated head and the stomodeum is shifted anteriorly.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Nonmotile germ cells.

    (Warrior, 1994)
    Stocks (3)
    Notes on Origin
    Discoverer

    C. Nusslein-Volhard.

    (Simpson, 1983)

    Nusslein-Volhard.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (12)
    References (90)