Aberration Dmel\Df(2L)M36F-S6

General Information
Symbol	Dmel\Df(2L)M36F-S6	Species	D. melanogaster
Name		FlyBase ID	FBab0001494
Feature type	chromosomal_deletion
Also Known As	Df(2L)M36-S6, M(2)m^S6

Computed Breakpoints include	36F2-36F6;36F2-36F6
Deleted segment	36F2--36F6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Wright et al., 1976, Duffy et al., 1996)
Breakpoints	36E6;36F9 (Wright et al., 1976) 36F2-36F6;36F2-36F6 (Duffy et al., 1996)
Causes alleles	Acp36DE^M36F-S6 (Marygold, 2005.1.19) Fas3^M36F-S6 (Marygold, 2005.1.19)
Carries alleles
Transposon Insertions
Formalized genetic data	kel << bk1 << l(2)36Fb << l(2)36Fd << bk2 << msl-1
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Palmer et al., 1993)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0086390) Right limit of break 1 from inclusion of M(2)36F (FBrf0028752) Limits of break 2 from polytene analysis (FBrf0086390)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	amos (Villa-Cuesta et al., 2003) ncm (Marygold, 2005.1.19, Coelho et al., 2005) RpS26 (Wright et al., 1976, Marygold, 2005.1.19)
Molecular Data
Completely deleted	amos (Marygold, 2005.1.19) bsf (Marygold, 2005.1.19) CG10176 (Marygold, 2005.1.19) CG10178 (Marygold, 2005.1.19) CG10211 (Marygold, 2005.1.19) CG10283 (Marygold, 2005.1.19) CG31749 (Marygold, 2005.1.19) kon (Marygold, 2005.1.19) ncm (Marygold, 2005.1.19) Pde11 (Marygold, 2005.1.19) RpS26 (Marygold, 2005.1.19)
Partially deleted	Acp36DE (Marygold, 2005.1.19) Fas3 (Marygold, 2005.1.19)
Genes NOT Deleted / Disrupted
Complementation Data
	msl-1 (Palmer et al., 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)M36F-S6 is semi-lethal in combination with either Df(2L)H20 or Df(2L)cact-255rv64. Surviving males and females are fertile. (Levine et al., 2007) Df(2L)MN-6 is semi-lethal in combination with Df(2L)M36F-S6. (Levine et al., 2007) Df(2L)T317/Df(2L)M36F-S6 animals are viable and fertile. (Levine et al., 2007) Inferred to overlap with: Df(2L)H20. (Marygold, 2005.1.19) Df(2L)TW203/Df(2L)M36F-S6 embryos show disorganisation of the peripheral nervous system. Dorsal bipolar neurons can not be seen. (Huang et al., 2000) Df(2L)M36F-S6/Df(2L)M36F-S5 lethal (Wright) Df(2L)M36F-S6/Df(2L)TW50 lethal (Wright) Df(2L)M36F-S6/Df(2L)hk18 lethal (Wright) Df(2L)M36F-S6Df(2L)E71 lethal (Wright) Df(2L)M36F-S6/Df(2L)TW3 lethal (Wright) Df(2L)M36F-S6/Df(2L)E53 lethal (Wright)
NOT in combination with other aberrations	Heterozygotes have a reduced number of sensilla trichodea on the antenna compared to wild-type flies. (Goulding et al., 2000) Homozygous embryos show disorganisation of the peripheral nervous system. Dorsal bipolar neurons can not be seen. (Huang et al., 2000) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Minute phenotype is not suppressed by RpL32^+t3.3. (Kongsuwan et al., 1985)
Stocks ( 2 )
Bloomington	343 Df(2L)M36F-S6/SM5
Kyoto	105861 Df(2L)M36F-S6 / SM5
Notes on Origin
Discoverer	Schultz, 12 Jan. 1933.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Df(2L)M36F-2 and Df(2L)M36F-S6 show the same genetic characteristics, raising the possibility that they might trace back to the same stock. (Marygold, 2005.1.19)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(2)M36F-S6 (Villa-Cuesta et al., 2003) Df(2L)M36F (Huang et al., 2000) Df(2L)M36F-S6 (Benton et al., 2009, Levine et al., 2007) Df(2L)M36-S6 (zur Lage et al., 2003, Holohan et al., 2006) Df(2L)M-mS6 Df(2L)S6 (Holohan et al., 2006) M(2)M (Duffy et al., 1996) M(2)m^S6 (Wright et al., 1976, Kongsuwan et al., 1985, ) M(2)S6
Name Synonym	Minute(2)m of Schultz
Secondary FlyBase IDs
	FBal0038897
References ( 17 )
Research paper	Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496] Levine et al., 2007, Genome 50(2): 137--141 Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. [FBrf0202301] Holohan et al., 2006, BMC Dev. Biol. 6: 53 Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos. [FBrf0195219] Coelho et al., 2005, Genetics 171(2): 597--614 A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. [FBrf0190712] Harbison et al., 2004, Genetics 166(4): 1807--1823 Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. [FBrf0174696] Presgraves, 2003, Genetics 163(3): 955--972 A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. [FBrf0158988] Villa-Cuesta et al., 2003, Genetics 163(4): 1403--1412 Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila. [FBrf0158981] zur Lage et al., 2003, Development 130(19): 4683--4693 The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation. [FBrf0162077] Goulding et al., 2000, Neuron 25(1): 69--78 amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. [FBrf0126762] Huang et al., 2000, Neuron 25(1): 57--67 The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. [FBrf0126761] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Palmer et al., 1993, Genetics 134(2): 545--557 The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. [FBrf0058602] Kongsuwan et al., 1985, Nature 317(6037): 555--558 A Drosophila Minute gene encodes a ribosomal protein. [FBrf0043337] Wright et al., 1976, Genetics 84: 267--285 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0028752]
Personal communication to FlyBase	Marygold, 2005.1.19, Genetics of the 36F region. Genetics of the 36F region. [FBrf0183166]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]