Aberration Dmel\Df(2L)RA5

General Information
Symbol	Dmel\Df(2L)RA5	Species	D. melanogaster
Name		FlyBase ID	FBab0001523
Feature type	chromosomal_deletion

Computed Breakpoints include	35E1;35F11-36A1
Deleted segment	35E1--36A1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	cact^E10 (Roote, 1996.8) P{FZ}cact²⁵⁵ (Landis and Tower, 1999)
Mutagen	irradiation (Roote, 1996.8)
Class of aberration (relative to progenitor)	chromosomal_deletion
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)35De << bk1 << fs(2)35Ec << l(2)35Fg << bk2 << dac
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of ms(2)35Eb (FBrf0051973) Left limit of break 2 from inclusion of mRpL4 (FBrf0051973) Right limit of break 2 from non-inclusion of dac (FBrf0051973)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	BicC (Eberl et al., 1998, Ashburner et al., 1990, Mahone et al., 1995) cact (Eberl et al., 1998, Ashburner et al., 1990, Levine et al., 2007) Ca-α1D (Eberl et al., 1998, Ashburner et al., 1990, Mahone et al., 1995) chif (Eberl et al., 1998, Ashburner et al., 1990, Roote, 1996.8, Levine et al., 2007) cni (Eberl et al., 1998, Ashburner et al., 1990) crp (Eberl et al., 1998) Cyp303a1 (Eberl et al., 1998, Ashburner et al., 1990) EndoGI (Temme et al., 2009) fs(2)35Ec (Roote, 1997.6.6) fzy (Eberl et al., 1998, Ashburner et al., 1990) heix (Eberl et al., 1998, Ashburner et al., 1990) l(2)35Fg (BDGP Project Members, 1994-1999, Roote, 1996.8, Roote, 2010.1.4, Levine et al., 2007) mRpL4 (Eberl et al., 1998, Ashburner et al., 1990, Roote, 1996.8, Levine et al., 2007) ms(2)35Eb (Eberl et al., 1998, Ashburner et al., 1990, Mahone et al., 1995, Roote, 1996.8) Syx5 (Eberl et al., 1998, Ashburner et al., 1990) twe (Eberl et al., 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ck (Ashburner et al., 1990) crp (Ashburner et al., 1990) Cul-3 (Ashburner et al., 1990) CycE (Ashburner et al., 1990) dac (Ashburner et al., 1990, Roote, 1996.8) esg (Ashburner et al., 1990) Gli (Ashburner et al., 1990) l(2)35Cc (Ashburner et al., 1990) l(2)35De (Ashburner et al., 1990, Roote, 1996.8) l(2)35Df (Ashburner et al., 1990) l(2)35Di (Ashburner et al., 1990) l(2)36Aa (Ashburner et al., 1990) l(2)36Ab (Ashburner et al., 1990) l(2)36Ac (Ashburner et al., 1990) l(2)36Ad (Ashburner et al., 1990) lace (Ashburner et al., 1990) plo (Ashburner et al., 1990) rd (Ashburner et al., 1990) sna (Ashburner et al., 1990) stc (Ashburner et al., 1990) Su(H) (Ashburner et al., 1990) TfIIS (Ashburner et al., 1990) vas (Ashburner et al., 1990) wek (Ashburner et al., 1990, Roote, 1996.8) wor (Ashburner et al., 1990)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)MN-I/Df(2L)RA5 animals are fertile. (Levine et al., 2007) Df(2L)RA5/Df(2L)H20 females have reduced fertility. (Levine et al., 2007) Female sterile in combination with Df(2L)TE35D-3. Male sterile in combination with Df(2L)TE35D-14. Viable in combination with Df(2L)TE35D-19. (Ashburner et al., 1999) Heterozygotes with Df(2L)el28, Df(2L)TE35B-2, In(2L)TE35B-13, Df(2L)Sco^rv10, Df(2L)Sco^rv14, Df(2L)TE35D-24, Df(2L)A246, In(2LR)pkD1-rv2, In(2LR)pkD1-rv3 or Df(2L)Adh-nBR120 exhibit a leaky female sterile phenotype (uncovering fs(2)35Ec). Heterozygotes with Df(2L)Sco7, Df(2L)TE35BC-8, Df(2L)TE35D-3, Df(2L)TE35D-11, Df(2L)TE35D-17, Df(2L)TE35D-5, Df(2L)TE35D-12 or In(2LR)noc^4LD6^R are completely female sterile (uncovering fs(2)35Ec). (Roote, 1997.6.6)
NOT in combination with other aberrations	Most eggs laid develop to hatched larvae, some are undeveloped due to a developmental block in the later syncytial divisions. (Mahone et al., 1995)
Stocks ( 2 )
Bloomington	6915 Df(2L)RA5/CyO
Kyoto	101430 Df(2L)RA5, sp¹ / CyO
Notes on Origin
Discoverer	Y. Hiromi. Y. Hiromi. (Roote, 1996.8)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Chif^RA5 (Cayirlioglu et al., 2003) Df(2L)RA5 (O'Keefe et al., 2011, Von Stetina et al., 2008, Temme et al., 2009, Roote, 2010.1.4, Gamberi, 2010.7.23, Levine et al., 2007) dfRA5 (Tower, 1999.12.23)
Name Synonym
Secondary FlyBase IDs

References ( 20 )
Research paper	O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Temme et al., 2009, J. Biol. Chem. 284(13): 8337--8348 The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. [FBrf0207466] Von Stetina et al., 2008, Development 135(22): 3697--3706 α-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. [FBrf0206240] Levine et al., 2007, Genome 50(2): 137--141 Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. [FBrf0202301] Zhang and Tower, 2004, Development 131(9): 2089--2099 Sequence requirements for function of the Drosophila chorion gene locus ACE3 replicator and ori- origin elements. [FBrf0174575] Cayirlioglu et al., 2003, Mol. Cell. Biol. 23(6): 2123--2134 Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. [FBrf0159210] Pipes et al., 2001, Development 128(22): 4545--4552 The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila. [FBrf0141485] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Landis and Tower, 1999, Development 126(19): 4281--4293 The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle. [FBrf0111407] Eberl et al., 1998, Genetics 148(3): 1159--1169 Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster. [FBrf0101896] Saffman et al., 1998, Mol. Cell. Biol. 18(8): 4855--4862 Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. [FBrf0104508] Mahone et al., 1995, EMBO J. 14(9): 2043--2055 Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. [FBrf0082309] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973]
Personal communication to FlyBase	Gamberi, 2010.7.23, Df(2L)A48 mapping information. Df(2L)A48 mapping information. [FBrf0211438] Roote, 2010.1.4, Analysis of Zuker alleles. Analysis of Zuker alleles. [FBrf0209649] Tower, 1999.12.23, PW62 chromosome. PW62 chromosome. [FBrf0125042] Roote, 1997.6.6, Alleles and aberrations update. Alleles and aberrations update. [FBrf0093866] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]