Aberration Dmel\Df(2L)RM5

General Information
Symbol	Dmel\Df(2L)RM5	Species	D. melanogaster
Name		FlyBase ID	FBab0001526
Feature type	chromosomal_deletion

Computed Breakpoints include	35E1;36A4-36A5
Deleted segment	35E1--36A5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	cact^E10 (Roote, 1996.8)
Mutagen	irradiation (Roote, 1996.8)
Class of aberration (relative to progenitor)	chromosomal_deletion
Breakpoints
Causes alleles	beat-Ic^RM5 (Pipes et al., 2001)
Carries alleles
Transposon Insertions
Formalized genetic data	ms(2)35Eb << bk1 << fs(2)35Ed << dac << bk2 << her
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of ms(2)35Eb (FBrf0051973) Right limit of break 1 from inclusion of BicC (FBrf0051973) Limits of break 2 from polytene analysis (citation unavailable)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	beat-Ia (Roote, 1999.1.18, Fambrough and Goodman, 1996) BicC (Roote, 1999.1.18, Ashraf et al., 1999, Ashburner et al., 1990, Mahone et al., 1995, Fambrough and Goodman, 1996) cact (Ashburner et al., 1990) Ca-α1D (Ashburner et al., 1990) chif (Ashburner et al., 1990) cni (Ashburner et al., 1990) crp (Ashburner et al., 1990) Cyp303a1 (Ashburner et al., 1990) dac (Ashraf et al., 1999, Ashburner et al., 1990) fs(2)35Ed (Roote, 1997.6.6) fzy (Ashburner et al., 1990) heix (Ashburner et al., 1990) mRpL4 (Ashburner et al., 1990) Syx5 (Ashburner et al., 1990)
Molecular Data
Completely deleted	beat-Ic (Certel and Thor, 2004)
Genes NOT Deleted / Disrupted
Complementation Data
	ck (Ashburner et al., 1990) Cul-3 (Ashburner et al., 1990) CycE (Ashburner et al., 1990) esg (Ashburner et al., 1990) Gli (Ashburner et al., 1990) her (Li and Baker, 1998) l(2)35Cc (Ashburner et al., 1990) l(2)35De (Ashburner et al., 1990) l(2)35Df (Ashburner et al., 1990) l(2)35Di (Ashburner et al., 1990) l(2)36Aa (Ashburner et al., 1990) l(2)36Ab (Ashburner et al., 1990) l(2)36Ac (Ashburner et al., 1990) l(2)36Ad (Ashburner et al., 1990) lace (Ashburner et al., 1990) ms(2)35Eb (Ashburner et al., 1990) plo (Ashburner et al., 1990) rd (Ashburner et al., 1990) sna (Ashburner et al., 1990) stc (Ashburner et al., 1990) Su(H) (Ashburner et al., 1990) TfIIS (Ashburner et al., 1990) vas (Ashburner et al., 1990) wek (Ashburner et al., 1990) wor (Ashburner et al., 1990)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	37% of ISNb nerves show a bypass phenotype in Df(2L)RM5/Df(2L)Sco^rv18 embryos (20% of ISNb nerves are wild type). 68% of ISNd nerves show a bypass phenotype in Df(2L)RM5/Df(2L)Sco^rv18 embryos (29% of ISNd nerves are wild type). (Pipes et al., 2001) Female sterile in combination with Df(2L)TE35D-2. (Ashburner et al., 1999) Viable in combination with Df(2L)TE35D-19. (Ashburner et al., 1999.10.12) Heterozygotes with Df(2L)TE35D-6, Df(2L)TE35D-2 or Df(2L)TE35D-14 are completely female sterile (uncovering fs(2)35Ed). Heterozygotes with Df(2L)Sco7 exhibit a leaky female sterile phenotype (uncovering fs(2)35Ec). (Roote, 1997.6.6) In Df(2L)Sco^rv18/Df(2L)RM5 transheterozygotes (beat-Ia^- BicC^-) the SNb fails to diverge from the ISN completely (full bypass) in 68% segments or partially (partial bypass) in 28% segments. In Df(2L)TE35D-19/Df(2L)RM5 transheterozygotes (beat-Ia⁺ BicC^-) the SNb fails to diverge from the ISN completely (full bypass) in 5% segments or partially (partial bypass) in 2% segments. (Fambrough and Goodman, 1996)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer	Y. Hiromi. Y. Hiromi. (Roote, 1996.8)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	beat Ic^Df1 (Certel and Thor, 2004) Df(2L)RM5 RM5 (Ashburner et al., 1999.10.12)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Certel and Thor, 2004, Development 131(21): 5429--5439 Specification of Drosophila motoneuron identity by the combinatorial action of POU and LIM-HD factors. [FBrf0180170] Pipes et al., 2001, Development 128(22): 4545--4552 The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila. [FBrf0141485] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Ashraf et al., 1999, EMBO J. 18(22): 6426--6438 The mesoderm determinant Snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis. [FBrf0111784] Li and Baker, 1998, Development 125(2): 225--235 Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. [FBrf0100594] Fambrough and Goodman, 1996, Cell 87(6): 1049--1058 The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. [FBrf0091058] Mahone et al., 1995, EMBO J. 14(9): 2043--2055 Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. [FBrf0082309] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Roote, 1999.1.18, Scorv18. Scorv18. [FBrf0106096] Roote, 1997.6.6, Alleles and aberrations update. Alleles and aberrations update. [FBrf0093866] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]