Aberration Dmel\Df(2L)RN2

General Information
Symbol	Dmel\Df(2L)RN2	Species	D. melanogaster
Name		FlyBase ID	FBab0001534
Feature type	chromosomal_deletion

Computed Breakpoints include	35F1-35F2;36A4-36A5
Deleted segment	35F1--36A5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	cact^E10 P{}cact^E10 (Roote, 1995.3.24)
Mutagen	irradiation (Roote, 1995.3.24)
Class of aberration (relative to progenitor)	chromosomal_deletion (Courtot et al., 1992, Roote, 1995.3.24)
Breakpoints	35E1-35E2;36A4-36A5 (Courtot et al., 1992, Roote, 1995.3.24)
Causes alleles	twe^RN2 (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
Carries alleles
Transposon Insertions
Formalized genetic data	Ca-α1D << bk1 << twe << dac << bk2 << her
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of Ca-α1D (FBrf0051973) Right limit of break 1 from inclusion of crp (FBrf0051973) Limits of break 2 from polytene analysis (FBrf0055870)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	cact (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) chif (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) cni (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) crp (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) Cyp303a1 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) dac (Ashburner et al., 1990, Roote, 1995.3.24) fzy (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1993, Dawson et al., 1995, Sigrist et al., 1995) heix (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) l(2)35Fg (Roote, 1995.3.24, Roote, 2010.1.4) mRpL4 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) Syx5 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) twe (Eberl et al., 1998, Ashburner et al., 1999, Courtot et al., 1992, White-Cooper et al., 1993, Dawson et al., 1995, Roote, 1997.12.2)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	BicC (Eberl et al., 1998, Ashburner et al., 1990) Ca-α1D (Eberl et al., 1998, Ashburner et al., 1990) ck (Ashburner et al., 1990) Cul-3 (Ashburner et al., 1990) CycE (Ashburner et al., 1990) esg (Ashburner et al., 1990) Gli (Ashburner et al., 1990) her (Li and Baker, 1998) l(2)35Cc (Ashburner et al., 1990) l(2)35De (Ashburner et al., 1990) l(2)35Df (Ashburner et al., 1990) l(2)35Di (Ashburner et al., 1990) l(2)36Aa (Ashburner et al., 1990) l(2)36Ab (Ashburner et al., 1990) l(2)36Ac (Ashburner et al., 1990) l(2)36Ad (Ashburner et al., 1990) lace (Ashburner et al., 1990) ms(2)35Eb (Eberl et al., 1998, Ashburner et al., 1990) plo (Ashburner et al., 1990) rd (Ashburner et al., 1990) sna (Ashburner et al., 1990) stc (Ashburner et al., 1990) Su(H) (Ashburner et al., 1990) TfIIS (Ashburner et al., 1990) vas (Ashburner et al., 1990) wek (Ashburner et al., 1990) wor (Ashburner et al., 1990)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Lethal in combination with In(2L)el18 or Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)DTD22. Inferred to overlap with: In(2L)el18. Inferred to overlap with: Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)DTD22. (Ashburner et al., 1999) Lethal in combination with Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)DTD22. (Ashburner et al., 1999.10.12)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer	Y. Hiromi. Y. Hiromi. (Roote, 1996.8) Roth. (Roote, 1995.3.24)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2L)RN2 (Roote, 2010.1.4) RN2 (Ashburner et al., 1999.10.12)
Name Synonym
Secondary FlyBase IDs

References ( 16 )
Research paper	Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Eberl et al., 1998, Genetics 148(3): 1159--1169 Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster. [FBrf0101896] Li and Baker, 1998, Development 125(2): 225--235 Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. [FBrf0100594] Dawson et al., 1995, J. Cell Biol. 129(3): 725--737 The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. [FBrf0081900] Sigrist et al., 1995, EMBO J. 14(19): 4827--4838 Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. [FBrf0084373] Dawson et al., 1993, Development 117(1): 359--376 Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. [FBrf0058082] White-Cooper et al., 1993, J. Cell Sci. 106(4): 1035--1044 The cdc25 homologue twine is required for only some aspects of the entry into meiosis in Drosophila. [FBrf0068733] Alphey et al., 1992, Cell 69(2): 977--988 twine, a cdc25 homolog that functions in the male and female germline of Drosophila. [FBrf0055587] Courtot et al., 1992, Development 116(2): 405--416 The Drosophila cdc25 homolog twine is required for meiosis. [FBrf0055870] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973]
Personal communication to FlyBase	Roote, 2010.1.4, Analysis of Zuker alleles. Analysis of Zuker alleles. [FBrf0209649] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Roote, 1997.12.2, l(2)35Fh. l(2)35Fh. [FBrf0099486] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813] Roote, 1995.3.24, Help FlyBase - Roote 2. Help FlyBase - Roote 2. [FBrf0077931]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]