FlyBase Aberration Report: Dmel\Df(2L)S2

General Information

Symbol

Df(2L)S2

Species

D. melanogaster

Name

Deficiency (2L) Star

FlyBase ID

FBab0001537

Feature type

chromosomal_deletion

Also Known As

Df(2L)S²

Computed Breakpoints include

21C8-21D1;22A8-22B1

Features within 21C8--22B1

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Clark et al., 1995, Roberts et al., 1985, Lewis, 1945)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Fostier et al., 1998, Duffy et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Schupbach and Wieschaus, 1991, de Belle et al., 1989, Roberts et al., 1985, Lewis, 1945)

Breakpoints

21C8;22A8

(Lewis, 1945)

21C6-21D1;22A6-22B1

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Gsc << bk1 << lea << bk2 << Got2

Genetic mapping information

Comments

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left break appears to be just left of 21D1-21D2, right break appears to be just before 22B1-22B2, although the breaks may be in the middle of these two doublets.

(Lewis, 1945)

Left limit of break 1 from polytene analysis (FBrf0006343) Right limit of break 1 from polytene analysis (FBrf0042627) Left limit of break 2 from polytene analysis (FBrf0006343) Right limit of break 2 from polytene analysis (FBrf0042627)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

ast

(Roberts et al., 1985, Lewis, 1945)

chinmo

(Ma et al., 2014, Welte, 2000.2.23)

cpb

(Delalle et al., 2005, Welte, 2000.2.23)

dock

(BDGP Project Members, 1994-1999)

(Clark et al., 1995, Lewis, 1945)

frtz

(Collier et al., 2005)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23)

(Welte, 2000.2.23, Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987)

(Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987, Lewis, 1945)

shr

(Lewis, 1945)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Lewis, 1945)

dpp

(Lewis, 1945)

for

(de Belle et al., 1989)

Gsc

(BDGP Project Members, 1994-1999)

l(2)02321

(BDGP Project Members, 1994-1999)

l(2)gl

(Mason et al., 2004, Lewis, 1945)

mbm

(Heisenberg et al., 1985)

net

(Lewis, 1945)

(Kania et al., 1995, BDGP Project Members, 1994-1999)

Su(dx)

(Fostier et al., 1998)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

NOT in combination with other aberrations

Heterozygosity for Df(2L)S2 results in 0.3% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation.

(Bilder and Scott, 1995)

Homozygous embryos have head defects and tracheae are disconnected.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (1)

Bloomington

6697

Df(2L)S2/CyO

Notes on Origin

Discoverer

E.B. Lewis, 1940.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2L)S2 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt.

(Mason et al., 2004)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Df(2)S2

(Golubovsky et al., 1978)

Df(2L)S-2

(Tearle and Nusslein-Volhard, 1987)

Df(2L)S2

(Ma et al., 2014, Crest et al., 2007)

Df(2L)S2,S

(Abrell et al., 2000)

Df(2L)S²

(Schupbach and Wieschaus, 1989, Wustmann et al., 1989)

Df-S2

(Lewis, 1945)

S^Df2

Name Synonyms

Deficiency (2L) Star

Secondary FlyBase IDs

References (34)

Report Sections

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