Aberration Dmel\Df(2L)S2

General Information
Symbol	Dmel\Df(2L)S2	Species	D. melanogaster
Name	Deficiency (2L) Star	FlyBase ID	FBab0001537
Feature type	chromosomal_deletion

Computed Breakpoints include	21C8-21D1;22A8-22B1
Deleted segment	21C8--22B1
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Clark et al., 1995, Lewis, 1945, Roberts et al., 1985)
Class of aberration (relative to progenitor)	chromosomal_deletion (Schupbach and Wieschaus, 1991, Kania et al., 1995, Pauli et al., 1995, de Belle et al., 1989, Duffy et al., 1996, Lewis, 1945, Harbecke and Lengyel, 1995, Roberts et al., 1985, Fostier et al., 1998)
Breakpoints	21C6-21D1;22A6-22B1 (Roberts et al., 1985, de Belle et al., 1989, Schupbach and Wieschaus, 1991, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Fostier et al., 1998) 21C8;22A8 (Lewis, 1945)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	Gsc << bk1 << lea << bk2 << Got2
Genetic mapping information
Comments
Comments on Cytology
	Ref: Lindsley and Zimm, 1992 (Kania et al., 1995) Left break appears to be just left of 21D1-21D2, right break appears to be just before 22B1-22B2, although the breaks may be in the middle of these two doublets. (Lewis, 1945) Left limit of break 1 from polytene analysis (FBrf0006343) Right limit of break 1 from polytene analysis (FBrf0042627) Left limit of break 2 from polytene analysis (FBrf0006343) Right limit of break 2 from polytene analysis (FBrf0042627)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ast (Roberts et al., 1985, Lewis, 1945) chinmo (Welte, 2000.2.23) cpb (Welte, 2000.2.23, Delalle et al., 2005) dock (BDGP Project Members, 1994-1999) ds (Lewis, 1945, Clark et al., 1995) frtz (Collier et al., 2005) l(2)22Af (Welte, 2000.2.23) l(2)22Ag (Welte, 2000.2.23) l(2)22Ah (Welte, 2000.2.23) l(2)22Ai (Welte, 2000.2.23) l(2)22Aj (Welte, 2000.2.23) l(2)22Ak (Welte, 2000.2.23) lea (Welte, 2000.2.23, Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995) RFeSP (Welte, 2000.2.23) S (Tearle and Nusslein-Volhard, 1987, Lewis, 1945, Harbecke and Lengyel, 1995) shr (Lewis, 1945)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	al (Lewis, 1945) dpp (Lewis, 1945) ex (Lewis, 1945) for (de Belle et al., 1989) Gsc (BDGP Project Members, 1994-1999) l(2)02321 (BDGP Project Members, 1994-1999) l(2)gl (Mason et al., 2004, Lewis, 1945) mbm (Heisenberg et al., 1985) net (Lewis, 1945) S (BDGP Project Members, 1994-1999, Kania et al., 1995) Su(dx) (Fostier et al., 1998)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	Heterozygosity for Df(2L)S2 results in 0.3% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Deficient embryos show a variably penetrant mutant midgut phenotype: incomplete constriction formation. (Bilder and Scott, 1995) Homozygous embryos have head defects and tracheae are disconnected. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 1 )
Bloomington	6697 Df(2L)S2/CyO
Notes on Origin
Discoverer	E.B. Lewis, 1940.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)S2 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Df(2)S2 (Golubovsky et al., 1978) Df(2L)S-2 (Tearle and Nusslein-Volhard, 1987) Df(2L)S2 (Crest et al., 2007) Df(2L)S2,S (Abrell et al., 2000) Df(2L)S² (Schupbach and Wieschaus, 1989, Wustmann et al., 1989) Df-S2 (Lewis, 1945) S^Df2
Name Synonym	Deficiency (2L) Star
Secondary FlyBase IDs

References ( 33 )

Generate a list of	All references relating to this aberration ( 33 )

List References by type	Research paper ( 28 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...