Aberration Dmel\Df(2L)Sco7

General Information
Symbol	Dmel\Df(2L)Sco7	Species	D. melanogaster
Name	Deficiency (2L) Scutoid	FlyBase ID	FBab0001554
Feature type	chromosomal_deletion

Computed Breakpoints include	34D4;35E1
Deleted segment	34D4--35E1
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	2L:13,810,408..13,816,406 [+] (Df(2L)Sco7:bk1) (Simon et al., 1991)
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Tp(2;2)Sco (Ashburner et al., 1981, Ashburner and Harrington, 1984)
Mutagen	X ray (Ashburner et al., 1981)
Class of aberration (relative to progenitor)	chromosomal_deletion (Ashburner and Harrington, 1984, Ashburner et al., 1981)
Breakpoints	34D4;35D5-35D7 (Ashburner and Harrington, 1984) 34D5;35D5-35D7 (Ashburner et al., 1981)
Causes alleles	Sos^Sco7 (Bonfini et al., 1992)
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)34Db << bk1 << Sos << fs(2)35Ec << bk2 << BicC
Genetic mapping information
Comments
Comments on Cytology
	Deficient for P{w^bcd.2.5}b to rd. (Ashburner et al., 1981) Left limit of break 1 from polytene analysis (FBrf0040522) Right limit of break 1 from inclusion of Sos (FBrf0057637) Left limit of break 2 from inclusion of ms(2)35Eb (FBrf0051973) Right limit of break 2 from non-inclusion of BicC (FBrf0051973)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Adh (Ashburner et al., 1983) b (Ashburner et al., 1981) ck (Ashburner et al., 1990) Cul-3 (Ashburner et al., 1983, Ashburner et al., 1990) CycE (Ashburner et al., 1983, Ashburner et al., 1990) elA (Ashburner et al., 1983) esg (Ashburner et al., 1990) fs(2)35Ec (Roote, 1997.6.6) fs(2)35Ed (Roote, 1997.6.6) Gli (Ashburner et al., 1990) l(2)35Cc (Ashburner et al., 1990) l(2)35De (Ashburner et al., 1990) l(2)35Df (Ashburner et al., 1990) l(2)35Di (Ashburner et al., 1990) lace (Ashburner et al., 1983, Ashburner et al., 1990) mol (Ashburner et al., 1983) ms(2)35Eb (Ashburner et al., 1990, Roote, 1996.8) nimC4 (Kurant et al., 2008) noc (Ashburner et al., 1983) osp (Ashburner et al., 1983) pu (Ashburner et al., 1983) rd (Ashburner et al., 1981, Ashburner et al., 1983, Ashburner et al., 1990) sna (Ashburner et al., 1983, Ashburner et al., 1990) Sos (Bonfini et al., 1992) stc (Ashburner et al., 1983, Ashburner et al., 1990) Su(H) (Ashburner et al., 1990) tam (Roote, 1996.8) TfIIS (Ashburner et al., 1990) vas (Ashburner et al., 1990) wek (Ashburner et al., 1990) wor (Ashburner et al., 1983, Ashburner et al., 1990)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	BicC (Ashburner et al., 1990, Roote, 1996.8) cact (Ashburner et al., 1990) Ca-α1D (Ashburner et al., 1990) chif (Ashburner et al., 1990) cni (Ashburner et al., 1990) crp (Ashburner et al., 1990) Cyp303a1 (Ashburner et al., 1990) dac (Ashburner et al., 1990) fzy (Ashburner et al., 1990) heix (Ashburner et al., 1990) kuz (Bonfini et al., 1992) l(2)34Db (Bonfini et al., 1992) l(2)36Aa (Ashburner et al., 1990) l(2)36Ab (Ashburner et al., 1990) l(2)36Ac (Ashburner et al., 1990) l(2)36Ad (Ashburner et al., 1990) mRpL4 (Ashburner et al., 1990) plo (Ashburner et al., 1990) Sos (Roote, 1996.8) Syx5 (Ashburner et al., 1990)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Heterozygotes with Df(2L)RM5 exhibit a leaky female sterile phenotype (uncovering fs(2)35Ec). Heterozygotes with Df(2L)RA5 are completely female sterile (uncovering fs(2)35Ec). (Roote, 1997.6.6)
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	6069 Df(2L)Sco7/CyO, Adh^nB
Kyoto	108583 Df(2L)Sco7/CyO, Adh^nB
Notes on Origin
Discoverer	E.H.Grell. E.H. Grell. (Ashburner et al., 1981)
	Revertant
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Not the same aberration as T(2;3)Sco^rv7; the potential for confusion is particularly great since T(2;3)Sco^rv7 is itself associated with a deficiency and has been termed Df(2L)ScoR+7.
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	41624 (Eriksen et al., 2000) Df(2L)Sco7 (Kurant et al., 2008) Df(2L)Sco^R+7 (Ashburner et al., 1982) Df(2L)Sco^R+ Df(2L)Sco^rev7 (Ashburner et al., 1981, Ashburner and Harrington, 1984) Df(2L)Sco^rv7 Df(2L)ScoRV7 (Bonfini et al., 1992) Df(2L)Scorv7 (Roote, 1996.8, ) Sco^rev7 (Ashburner et al., 1983) Scorv7 (Ashburner et al., 1990)
Name Synonym	Deficiency (2L) Scutoid
Secondary FlyBase IDs

References ( 16 )
Research paper	Kurant et al., 2008, Cell 133(3): 498--509 Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons. [FBrf0204720] Sawamura et al., 2004, Genetics 166(2): 789--796 Genetic complexity underlying hybrid male sterility in Drosophila. [FBrf0174711] Eriksen et al., 2000, Genome Res. 10(7): 924--938 Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster. [FBrf0128457] Bonfini et al., 1992, Science 255: 603--606 The Son of sevenless gene product: a putative activator of Ras. [FBrf0057637] Simon et al., 1991, Cell 67(23): 701--716 Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. [FBrf0053392] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973] McGill et al., 1988, Genetics 119: 647--661 The molecular analysis of an antimorphic mutation of Drosophila melanogaster, Scutoid. [FBrf0048235] Chia et al., 1985, J. molec. Biol. 186(2): 689--706 Molecular analysis of the Adh region of the genome of Drosophila melanogaster. [FBrf0043115] Ashburner and Harrington, 1984, Chromosoma 89: 329--337 A cytological analysis of the Scutoid mutation of Drosophila melanogaster, and its induced revertants. [FBrf0040522] Ashburner et al., 1983, Genetics 104: 405--431 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455] Ashburner et al., 1982, Genetics 102: 421--435 The genetics of a small autosomal region of Drosophila melanogaster, including the structural gene for alcohol dehydrogenase. [FBrf0038050] Ashburner et al., 1981, D. I. S. 56: 186--191 Report of New Mutants. [FBrf0036112]
Personal communication to FlyBase	Roote, 1997.6.6, Alleles and aberrations update. Alleles and aberrations update. [FBrf0093866] Roote, 1996.8, Aberration data. Aberration data. [FBrf0092813]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\Df(2L)Sco7

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