Aberration Dmel\Df(2L)TE21A

General Information
Symbol	Dmel\Df(2L)TE21A	Species	D. melanogaster
Name		FlyBase ID	FBab0001565
Feature type	chromosomal_deletion

Computed Breakpoints include	21A1;21B6
Deleted segment	21A1--21B6
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Tp(1;2)TE21Aa
Mutagen	gamma ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Caggese et al., 1988, Pauli et al., 1995, Frenz and Glover, 1996, Gellon et al., 1997)
Breakpoints	21A1-21B4;21B6 (Gellon et al., 1997) 21A1;21B4-21B6 (Caggese et al., 1988, Pauli et al., 1995, Frenz and Glover, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << spen << Gs1 << bk2 << kis
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0047556) Left limit of break 2 from polytene analysis (FBrf0098246) Right limit of break 2 from polytene analysis (FBrf0047556)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Gs1 (Caggese et al., 1988, Caggese et al., 1992, Caggese et al., 1994, Frenz and Glover, 1996) l(2)21Ba (Caggese et al., 1988, Caggese et al., 1994) l(2)21Ba1 (Caggese et al., 1994) l(2)21Bb (Caggese et al., 1988, Caggese et al., 1994) l(2)21Bd (Caggese et al., 1988, Caggese et al., 1994) l(2)gl (Caggese et al., 1994, Zarnescu et al., 2005) net (Caggese et al., 1988, Caggese et al., 1994) spen (Staehling-Hampton et al., 1999, Gellon et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	al (Caggese et al., 1988, Caggese et al., 1994) kis (Daubresse et al., 1999) l(2)21Be (Caggese et al., 1994)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Female sterile. (Caggese et al., 1992)
Stocks ( 3 )
Bloomington	3635 w^*; Df(2L)TE21A, w⁺/SM6a
Kyoto	107144 w^*; Df(2L)TE21A, w⁺/SM6a 101431 Df(2L)TE21A, w⁺ / SM6a, al² Cy¹ dp^lv1 cn² sp²
Notes on Origin
Discoverer	Ising.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)TE21A (Zarnescu et al., 2005) Df(2L)TE75 (Daubresse et al., 1999, Gellon et al., 1997, Frenz and Glover, 1996, Caggese et al., 1992, Caggese et al., 1988, ) Df(2L)TE75w+ (Pauli et al., 1995) DfnetTE75 (Caggese et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Zarnescu et al., 2005, Dev. Cell 8(1): 43--52 Fragile X protein functions with lgl and the par complex in flies and mice. [FBrf0183882] Daubresse et al., 1999, Development 126(6): 1175--1187 The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. [FBrf0107669] Staehling-Hampton et al., 1999, Genetics 153(1): 275--287 A genetic screen for modifiers of E2F in Drosophila melanogaster. [FBrf0111491] Wiellette et al., 1999, Development 126(23): 5373--5385 spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. [FBrf0112078] Gellon et al., 1997, Development 124(17): 3321--3331 A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. [FBrf0098246] Frenz and Glover, 1996, J. Cell Sci. 109(11): 2649--2660 A maternal requirement for glutamine synthetase I for the mitotic cycles of syncytial Drosophila embryos. [FBrf0090559] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Caggese et al., 1992, Dev. Genet. 13(5): 359--366 Mutations in the glutamine synthetase I (GsI) gene produce embryo-lethal female sterility in Drosophila melanogaster. [FBrf0055830] Caggese et al., 1988, Biochem. Genet. 26(9--10): 571--584 Genetic determinants of glutamine synthetase in Drosophila melanogaster: a gene for glutamine synthetase I resides in the 21B3-6 region. [FBrf0047556] Ising and Block, 1981, Cold Spring Harbor Symp. Quant. Biol. 45: 527--544 Derivation-dependent distribution of insertion sites for a Drosophila transposon. [FBrf0036018]
Review	Caggese et al., 1994, Genetica 94(2-3): 275--281 Genetic, molecular and developmental analysis of the glutamine synthetase isozymes of Drosophila melanogaster. [FBrf0079921]
Abstract	Sakamoto et al., 2001, A. Dros. Res. Conf. 42: 745A spen/MINT negatively regulates transcription in Notch signaling pathway. [FBrf0133580]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]