Aberration Dmel\Df(2L)TW203

General Information
Symbol	Dmel\Df(2L)TW203	Species	D. melanogaster
Name	Deficiency (2L) Ted Wright	FlyBase ID	FBab0001652
Feature type	chromosomal_deletion

Computed Breakpoints include	36E-36E3;37B10
Deleted segment	36E--37B10
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	amos^Tft
Mutagen	gamma ray (Stathakis et al., 1995) X ray (Wright et al., 1981)
Class of aberration (relative to progenitor)	chromosomal_deletion (Steward and Nusslein-Volhard, 1986, Wright et al., 1981, Stathakis et al., 1995)
Breakpoints	36E3-36F2;37B9-37C2 (Wright et al., 1981) 36E4-36F1;37B9-37C1 (Stathakis et al., 1995) 36E4-36F2;37B9-37C2 (Steward and Nusslein-Volhard, 1986)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	CadN << bk1 << rdo << hk << bk2 << l(2)37Be
Genetic mapping information
Comments	Molecular biology: Proximal breakpoint distal to -59 kb (Ddc coordinates from Gilbert, Hirsh and Wright, 1984)
Comments on Cytology
	Left limit of break 1 from non-inclusion of CadN (FBrf0044468) Right limit of break 1 from inclusion of kel (FBrf0044468) Left limit of break 2 from inclusion of hk (FBrf0035993) Right limit of break 2 from non-inclusion of Catsup (FBrf0044480)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	amos (Chien, 1999.9.15, Wright et al., 1981) hk (Wright et al., 1981, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) kel (Steward and Nusslein-Volhard, 1986) ninaD (Steward and Nusslein-Volhard, 1986) rdo (Wright et al., 1981, Steward and Nusslein-Volhard, 1986) RpS26 (Wright et al., 1981)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Aats-asn (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Acn (Stathakis et al., 1995, Wright, 1996, Pentz et al., 1986) amd (Stathakis et al., 1995, Wright, 1996) BicD (Steward and Nusslein-Volhard, 1986) brat (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) CadN (Steward and Nusslein-Volhard, 1986) Catsup (Pentz et al., 1986, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) cub (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Ddc (Stathakis et al., 1995, Wright, 1996) dl (Steward and Nusslein-Volhard, 1986) l(2)36Aa (Steward and Nusslein-Volhard, 1986) l(2)36Ab (Steward and Nusslein-Volhard, 1986) l(2)36Ac (Steward and Nusslein-Volhard, 1986) l(2)36Ad (Steward and Nusslein-Volhard, 1986) l(2)36Ba (Steward and Nusslein-Volhard, 1986) l(2)36Bb (Steward and Nusslein-Volhard, 1986) l(2)36Bc (Steward and Nusslein-Volhard, 1986) l(2)36Bd (Steward and Nusslein-Volhard, 1986) l(2)36Ca (Steward and Nusslein-Volhard, 1986) l(2)37Bb (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cb (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cc (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cd (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Ce (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cg (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Lim3 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Mhc (Steward and Nusslein-Volhard, 1986) mib2 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) plo (Steward and Nusslein-Volhard, 1986) qua (Steward and Nusslein-Volhard, 1986) Rpn3 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) γTub37C (Stathakis et al., 1995, Wright, 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)TW203/Df(2L)M36F-S6 embryos show disorganisation of the peripheral nervous system. Dorsal bipolar neurons can not be seen. (Huang et al., 2000) Heterozygote with Df(2L)TW130 is viable and phenotypically hk. (Wright et al., 1981)
NOT in combination with other aberrations	Homozygous embryos show disorganisation of the peripheral nervous system. Dorsal bipolar neurons can not be seen. (Huang et al., 2000) Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22. (Burnette et al., 1999)
Stocks ( 1 )
Bloomington	8833 Df(2L)TW203/CyO, Dp(2;2)M(2)m⁺
Notes on Origin
Discoverer
	Revertant
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	37B9-37C1 breakpoint is between position -85.4 and -83.2 on the Ddc map relative to the HpaI restriction site near the 3' end of Ddc. (Stathakis et al., 1995)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)203 (Wright et al., 1981, ) Df(2L)TW203 TW203 (Chien, 1999.9.15)
Name Synonym	Deficiency (2L) Ted Wright
Secondary FlyBase IDs

References ( 11 )
Research paper	Huang et al., 2000, Neuron 25(1): 57--67 The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. [FBrf0126761] Burnette et al., 1999, Genetics 151(4): 1517--1529 Trans-acting factors required for inclusion of regulated exons in the Ultrabithorax mRNAs of Drosophila melanogaster. [FBrf0107631] Wright, 1996, J. Hered. 87(3): 175--190 The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster. [FBrf0089206] Stathakis et al., 1995, Genetics 141(2): 629--655 The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. [FBrf0084402] Pentz et al., 1986, Genetics 112(2): 843--859 A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. [FBrf0044480] Steward and Nusslein-Volhard, 1986, Genetics 113: 665--678 The genetics of the dorsal-Bicaudal-D region of Drosophila melanogaster. [FBrf0044468] Wright et al., 1981, Chromosoma 83(1): 45--58 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0035993]
Personal communication to FlyBase	Chien, 1999.9.15, EDRC99 - abstract ID65. EDRC99 - abstract ID65. [FBrf0111591] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]