A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(2L)TW50

General Information
SymbolDmel\Df(2L)TW50SpeciesD. melanogaster
NameDeficiency (2L) Ted WrightFlyBase IDFBab0001655
Feature typechromosomal_deletion
Also Known AsDf(2L)50
Computed Breakpoints include 36E4-36F1;38A6-38A7
Deleted segment36E4--38A7
Sequence coordinates
Member of large scale dataset(s)
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
atom feed
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Stathakis et al., 1995)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Wright et al., 1976, Pauli et al., 1995, Harbecke and Lengyel, 1995, Landecker et al., 1994, Boube et al., 1997, Pentz et al., 1990)
Breakpoints
36E4-36F1;38A6-38A7
(Wright et al., 1976, Pentz et al., 1990, Landecker et al., 1994, Pauli et al., 1995, Harbecke and Lengyel, 1995, Boube et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data kel << bk1 << fs(2)eo3 << Fs(2)Ket << bk2 << barr
Genetic mapping information
Comments
Distal DNA breakpoints given (Steward, McNally, and Schedl, 1984, Nature 311: 262-65)
 
hide Comments on Cytology
All limits from polytene analysis (FBrf0028752)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Aats-asn
(Wright et al., 1976)
amd
(Wright et al., 1976, Wright et al., 1976, Wright et al., 1982)
amos
(Wright et al., 1976)
brat
(Spradling et al., 1999, Wright et al., 1976, Schupbach and Wieschaus, 1991, BDGP Project Members, 1994-1999)
Catsup
(Spradling et al., 1999, Wright et al., 1976, BDGP Project Members, 1994-1999)
Ddc
(Spradling et al., 1999, Wright et al., 1976, Wright et al., 1976, BDGP Project Members, 1994-1999)
esc
(Wright et al., 1976)
fs(2)38ABa
(Butler et al., 2001)
Fs(2)Ket
(Schupbach and Wieschaus, 1991)
fs(2)lto3
(Schupbach and Wieschaus, 1991)
fs(2)ltoPP43
(Spradling et al., 1999, Butler et al., 2001, Schupbach and Wieschaus, 1991, BDGP Project Members, 1994-1999)
fs(2)ltoRV64
(Schupbach and Wieschaus, 1991)
hk
(Wright et al., 1976)
huc2L-20
(Silva et al., 2006)
l(2)37Ad
(Doerig, 1999.8.9, Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)37Bb
(Wright et al., 1976)
l(2)37Cb
(Wright et al., 1976)
l(2)37CDa
(Wright et al., 1976)
l(2)37CDb
(Wright et al., 1976)
l(2)37CDc
(Wright et al., 1976)
l(2)37CDd
(Wright et al., 1976)
l(2)37CDe
(Wright et al., 1976)
l(2)37CDf
(Wright et al., 1976)
l(2)37Db
(Spradling et al., 1999, Wright et al., 1976, BDGP Project Members, 1994-1999)
l(2)37Dc
(Wright et al., 1976)
l(2)37De
(Wright et al., 1976)
l(2)37Di
(Wright et al., 1976)
l(2)37Dk
(Wright et al., 1976)
l(2)37Dl
(Wright et al., 1976)
l(2)37Dm
(Wright et al., 1976)
l(2)37Ea
(Butler et al., 2001)
l(2)37Fe
(Butler et al., 2001)
l(2)38ABa
(Butler et al., 2001)
l(2)k13805
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k14614
(BDGP Project Members, 1994-1999)
Lar
(Maurel-Zaffran et al., 2001)
ms(2)38ABa
(Butler et al., 2001)
msl-1
(Bevan et al., 1993)
pre
(Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991)
RpL30
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
RpS26
(Wright et al., 1976)
scw
(Butler et al., 2001, Nusslein-Volhard et al., 1984, Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995)
spi
(Spradling et al., 1999, Faucheux et al., 2001, BDGP Project Members, 1994-1999, Tio et al., 1994, Harbecke and Lengyel, 1995)
swm
(Wright et al., 1976)
γTub37C
(Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991)
Molecular Data
Completely deleted
CG10178
(Marygold, 2005.1.19)
CG10211
(Marygold, 2005.1.19)
Pde11
(Marygold, 2005.1.19)
hide Genes NOT Deleted / Disrupted
Complementation Data
barr
(Butler et al., 2001, BDGP Project Members, 1994-1999, Bhat et al., 1996)
Bl
(Butler et al., 2001, Wright et al., 1976)
bun
(BDGP Project Members, 1994-1999)
CadN
(Brumby et al., 2004)
crc
(Wright et al., 1976)
crp
(BDGP Project Members, 1994-1999)
dia
(Butler et al., 2001)
esg
(BDGP Project Members, 1994-1999)
Fs(2)Ket
(Butler et al., 2001)
l(2)38Ab
(Butler et al., 2001)
l(2)38ABb
(Butler et al., 2001)
l(2)38Db
(Butler et al., 2001)
l(2)38EFd
(Spradling et al., 1999, Butler et al., 2001, BDGP Project Members, 1994-1999)
l(2)10206
(BDGP Project Members, 1994-1999)
l(2)k02501
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k03002a
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k07525
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k07713
(Butler, 2001)
l(2)k09005
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k09314b
(BDGP Project Members, 1994-1999)
l(2)k09601
(BDGP Project Members, 1994-1999)
l(2)k09613
(BDGP Project Members, 1994-1999)
l(2)k09927
(BDGP Project Members, 1994-1999)
l(2)k10239
(Spradling et al., 1999, Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k11537
(BDGP Project Members, 1994-1999)
l(2)k14810
(Butler, 2001)
l(2)k16703
(Butler, 2001)
lt
(Wright et al., 1976)
lwr
(Butler, 2001, BDGP Project Members, 1994-1999)
M(2)39F
(Wright et al., 1976)
mat(2)cell-G
(Butler, 2001)
mat(2)ea-H
(Butler, 2001)
ncm
(Marygold, 2005.1.19, Coelho et al., 2005)
neb
(BDGP Project Members, 1994-1999, Bhat et al., 1996, Ohkura et al., 1997)
pr
(Butler et al., 2001)
RpS26
(Marygold, 2005.1.19)
spir
(Butler et al., 2001)
squ
(Butler, 2001)
tyr1
(Pentz et al., 1990)
vls
(Butler et al., 2001, Schupbach and Wieschaus, 1986)
Molecular Data
Acp36DE
(Marygold, 2005.1.19)
bsf
(Marygold, 2005.1.19)
CG10176
(Marygold, 2005.1.19)
CG10283
(Marygold, 2005.1.19)
CG31749
(Marygold, 2005.1.19)
Fas3
(Marygold, 2005.1.19)
kon
(Marygold, 2005.1.19)
ncm
(Marygold, 2005.1.19)
RpS26
(Marygold, 2005.1.19)
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Df(2L)MN-6 is semi-lethal in combination with Df(2L)TW50. Surviving females have reduced fertility (male adults are not recovered).
(Levine et al., 2007)
Df(2L)MN-casspr shows reduced viability in combination with Df(2L)TW50.
(Levine et al., 2007)
Df(2L)T317/Df(2L)TW50 animals are viable and fertile.
(Levine et al., 2007)
Df(2L)TW50 is semi-lethal in combination with Df(2L)cact-255rv64.
(Levine et al., 2007)
Inferred to overlap with: Df(2L)TW137.
(Marygold, 2005.1.19)
Viable and fertile in combination with Df(2L)pr2b. Viable and fertile in combination with Df(2L)pr37. Semilethal, male fertile and female subfertile in combination with Df(2L)pr11163. Semilethal and fertile in combination with Df(2L)pr-M1. Viable, male fertile and female subfertile in combination with Df(2L)pr49. Viable, male sterile and female subfertile in combination with Df(2L)pr8311. Male sterile in combination with Df(2L)pr1122. Semilethal and male and female sterile in combination with Df(2L)TW1. Semilethal in combination with Df(2L)TW161.
(Butler et al., 2001)
No effect on In(1)wm4h position-effect variegation.
(Wustmann et al., 1989)
NOT in combination with other aberrations
Intermediate second site non-complementing phenotype with zipEbr and zipmhc-c6.1: malformed phenotype penetrance 25-75%.
(Halsell and Kiehart, 1998)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
Shows a dose-sensitive interaction with pbhs.PB.
(Boube et al., 1997)
Deficient embryos show an uninterpretable mutant midgut phenotype.
(Bilder and Scott, 1995)
Mutation does not affect the level of w expression in ph-plac+3 flies.
(Fauvarque et al., 1995)
Homozygous embryos are very abnormal compared to wild-type. The Malpighian tubule primordium forms but individual tubules do not bud out.
(Harbecke and Lengyel, 1995)
Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.
(Pauli et al., 1995)
Severe morphological defect.
(Smith et al., 1993)
Associated with a dominant very weak Minute phenotype.
(Wright et al., 1976)
hide Stocks ( 2 )
Bloomington
3189
Df(2L)TW50, cn1/CyO, Dp(2;2)M(2)m+
Kyoto
106903
Df(2L)TW50, cn1/CyO, Dp(2;2)M(2)m+
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
hide Separable Components
hide Other Comments
The Df(2L)TW50 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.
(Mason et al., 2004)
hide Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym
Df(2L)50
(Wright et al., 1982, Wright et al., 1976, Wright et al., 1976, Takano and McKee, 1995, Nusslein-Volhard et al., 1984, )
Df(2L)TW50
(Marygold, 2005.1.19, Crest et al., 2007, Casso et al., 2008, Silva et al., 2006, Levine et al., 2007)
Df(2L)TW50
(Tully et al., 1992)
Df(2R)TW50
(Sonnenfeld et al., 2004)
TW50
(Hirose et al., 2001)
Name Synonym
Deficiency (2L) Ted Wright
 
Secondary FlyBase IDs
hide References ( 69 )
Generate a list of
List References by type
hide Recent research papers (0)
All research papers listed in FlyBase were published before 2011
Show research papers ...