Aberration Dmel\Df(2L)VA18

General Information
Symbol	Dmel\Df(2L)VA18	Species	D. melanogaster
Name		FlyBase ID	FBab0001671
Feature type	chromosomal_deletion

Computed Breakpoints include	36D1;37C2-37C5
Deleted segment	36D1--37C5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Gilbert et al., 1984, Stathakis et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gilbert et al., 1984, Steward and Nusslein-Volhard, 1986, Stathakis et al., 1995, Tavosanis et al., 1997, Whalen and Wilson, 1986)
Breakpoints	36C3-36D2;37C2-37D2 (Steward and Nusslein-Volhard, 1986) 36C4-36D1;37C2-37C5 (Stathakis et al., 1995) 36D1-36E1;37C1-37C5 (Gilbert et al., 1984, Whalen and Wilson, 1986) [];37C2--5 (Tavosanis et al., 1997)
Causes alleles	l(2)37Cc^VA18 (Black et al., 1987)
Carries alleles
Transposon Insertions
Formalized genetic data	qua << bk1 << AcpC << bk2 hits l(2)37Cc
Genetic mapping information
Comments	Proximal breakpoint is within the coding region of l(2)37Cc. Breakpoint(s) molecularly mapped (Black et al., 1987) Breakpoint(s) molecularly mapped (Pentz et al., 1986, Hirsh and Davidson, 1981, Gilbert et al., 1984, Stathakis, 1991) Ddc DNA coordinates from Gilbert, Hirsh and Wright, 1984, Genetics 106: 679-84: Proximal breakpoint between +5.1 and +5.6 kb
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0040975) Right limit of break 1 from polytene analysis (FBrf0084402) Left limit of break 2 from polytene analysis (FBrf0044468) Right limit of break 2 from polytene analysis (FBrf0040975)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Acn (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) AcpC (Whalen and Wilson, 1986) amd (Gilbert et al., 1984, Black et al., 1987, Stathakis et al., 1995, Wright, 1996) anon-37Ca (Black et al., 1987) CadN (Steward and Nusslein-Volhard, 1986) Catsup (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) CG10561 (Black et al., 1987) cub (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Ddc (Spradling et al., 1999, Gilbert et al., 1984, Black et al., 1987, Wright et al., 1982, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) hk (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) kel (Steward and Nusslein-Volhard, 1986) l(2)37Bb (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cc (Black et al., 1987, Stathakis et al., 1995) l(2)k13805 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Lim3 (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) mib2 (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) ninaD (Steward and Nusslein-Volhard, 1986) rdo (Steward and Nusslein-Volhard, 1986) RpL30 (BDGP Project Members, 1994-1999) Rpn3 (Pentz et al., 1986, Gilbert et al., 1984, Stathakis et al., 1995, Wright, 1996) RpS26 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Aac11 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Aats-asn (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) BicD (Steward and Nusslein-Volhard, 1986) brat (Gilbert et al., 1984, Pentz et al., 1986, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) dl (Steward and Nusslein-Volhard, 1986) l(2)36Aa (Steward and Nusslein-Volhard, 1986) l(2)36Ab (Steward and Nusslein-Volhard, 1986) l(2)36Ac (Steward and Nusslein-Volhard, 1986) l(2)36Ad (Steward and Nusslein-Volhard, 1986) l(2)36Ba (Steward and Nusslein-Volhard, 1986) l(2)36Bb (Steward and Nusslein-Volhard, 1986) l(2)36Bc (Steward and Nusslein-Volhard, 1986) l(2)36Bd (Steward and Nusslein-Volhard, 1986) l(2)36Ca (Steward and Nusslein-Volhard, 1986) l(2)37Cb (Pentz et al., 1986, Stathakis et al., 1995) l(2)37Cc (Pentz et al., 1986) l(2)37Cd (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Ce (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)37Cg (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) l(2)k09927 (BDGP Project Members, 1994-1999) l(2)k10816 (BDGP Project Members, 1994-1999) Mhc (Steward and Nusslein-Volhard, 1986) plo (Steward and Nusslein-Volhard, 1986) qua (Steward and Nusslein-Volhard, 1986) γTub37C (Stathakis et al., 1995, Wright, 1996, Tavosanis et al., 1997)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	6105 Df(2L)VA18, m¹ pr¹/CyO, Dp(2;2)M(2)m⁺
Kyoto	108608 Df(2L)VA18, m¹ pr¹/CyO, Dp(2;2)M(2)m⁺
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	37C2-37C5 breakpoint is between position +6.1 and +6.7 on the Ddc map relative to the HpaI restriction site near the 3' end of Ddc. (Stathakis et al., 1995) Proximal breakpoint is 2kb proximal to the 5' end of the Ddc coding region between coordinates +5.1 and +5.6, relative to the HpaI restriction site near the 3' end of Ddc. (Black et al., 1987)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2L)VA18 (Morris et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 18 )
Research paper	Morris et al., 2006, PLoS Genet. 2(11): e147 Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. [FBrf0194141] De Luca et al., 2003, Nat. Genet. 34(4): 429--433 Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. [FBrf0162261] Ward et al., 2003, Genetics 165(3): 1397--1415 Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. [FBrf0167639] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Tavosanis et al., 1997, EMBO J. 16(8): 1809--1819 Essential role for -tubulin in the acentriolar female meiotic spindle of Drosophila. [FBrf0093749] Wright, 1996, J. Hered. 87(3): 175--190 The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster. [FBrf0089206] Stathakis et al., 1995, Genetics 141(2): 629--655 The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. [FBrf0084402] Black et al., 1987, Mol. Gen. Genet. 209(2): 306--312 The alpha methyl dopa hypersensitive gene, l(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism. [FBrf0046993] Pentz et al., 1986, Genetics 112(2): 843--859 A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. [FBrf0044480] Steward and Nusslein-Volhard, 1986, Genetics 113: 665--678 The genetics of the dorsal-Bicaudal-D region of Drosophila melanogaster. [FBrf0044468] Whalen and Wilson, 1986, Genetics 114: 77--92 Variation and genomic localization of genes encoding Drosophila melanogaster male accessory gland proteins separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. [FBrf0044474] Gilbert et al., 1984, Genetics 106: 679--694 Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. [FBrf0040975] Wright et al., 1982, Mol. Gen. Genet. 188: 18--26 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0064843] Hirsh and Davidson, 1981, Mol. Cell. Biol. 1(6): 475--485 Isolation and characterization of the dopa decarboxylase gene of Drosophila melanogaster. [FBrf0037051]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338] Stathakis, 1991, [title not yet available] [title not yet available] [FBrf0075253]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]