Aberration Dmel\Df(2L)VA23

General Information
Symbol	Dmel\Df(2L)VA23	Species	D. melanogaster
Name		FlyBase ID	FBab0001677
Feature type	chromosomal_deletion

Computed Breakpoints include	37B9-37B10;37D5
Deleted segment	37B9--37D5
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	diepoxybutane (Stathakis et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Stathakis et al., 1995, Tavosanis et al., 1997)
Breakpoints	37B9-37C1;37D5 (Stathakis et al., 1995) 37B9--C1;[] (Tavosanis et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)37Bi << bk1 << hk << l(2)37Db << bk2 << l(2)37Dc
Genetic mapping information
Comments
Comments on Cytology
	Ref: Nolan et al., 1991, Potmesil, Kohn, 1991: 23--40. (Stathakis et al., 1995) Left limit of break 1 from polytene analysis (FBrf0084402) Right limit of break 1 from inclusion of Catsup (FBrf0084402) Limits of break 2 from polytene analysis (FBrf0084402)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aats-asn (Stathakis et al., 1995) Acn (Stathakis et al., 1995) amd (Stathakis et al., 1995) brat (Stathakis et al., 1995) Catsup (Stathakis et al., 1995) cub (Stathakis et al., 1995) Ddc (Stathakis et al., 1995) hk (Stathakis et al., 1995) l(2)37Bb (Stathakis et al., 1995) l(2)37Cb (Stathakis et al., 1995) l(2)37Cc (Stathakis et al., 1995) l(2)37Cd (Stathakis et al., 1995) l(2)37Ce (Stathakis et al., 1995) l(2)37Cg (Stathakis et al., 1995) Lim3 (Stathakis et al., 1995) mib2 (Stathakis et al., 1995) Rpn3 (Stathakis et al., 1995) γTub37C (Stathakis et al., 1995, Tavosanis et al., 1997, Hallen et al., 2008)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(2L)VA23/Df(2L)TW203 viable. Df(2L)VA23/Df(2L)TW203 'hook' phenotype.
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	3786 Df(2L)VA23, sna^Sco pr¹/CyO
Kyoto	107234 Df(2L)VA23, sna^Sco pr¹/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)VA23 chromosome acts as a weak dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004) 37D5 breakpoint is between position +16.2 and +17.0 on the Ddc map relative to the HpaI restriction site near the 3' end of Ddc. (Stathakis et al., 1995)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2L)VA23 (Hallen et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Hallen et al., 2008, Biophys. J. 95(6): 3048--3058 Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle. [FBrf0207345] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] De Luca et al., 2003, Nat. Genet. 34(4): 429--433 Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. [FBrf0162261] Presgraves, 2003, Genetics 163(3): 955--972 A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. [FBrf0158988] Endow and Komma, 1998, J. Cell Sci. 111(17): 2487--2495 Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. [FBrf0104747] Tavosanis et al., 1997, EMBO J. 16(8): 1809--1819 Essential role for -tubulin in the acentriolar female meiotic spindle of Drosophila. [FBrf0093749] Stathakis et al., 1995, Genetics 141(2): 629--655 The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. [FBrf0084402] Gay and Contamine, 1993, Mol. Gen. Genet. 239(3): 361--370 Study of the ref(2)P locus of Drosophila melanogaster. [FBrf0059083] Nolan et al., 1991, Potmesil, Kohn, 1991: 23--40 Analyses of the Top2 gene from Drosophila melanogaster: structure, mapping and expression. [FBrf0085666]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]