Aberration Dmel\Df(2L)al

General Information
Symbol	Dmel\Df(2L)al	Species	D. melanogaster
Name	Deficiency (2L) aristaless	FlyBase ID	FBab0001692
Feature type	chromosomal_deletion

Computed Breakpoints include	21C1;21C7
Deleted segment	21C1--21C7
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	2L:300,574..303,911 [+] (Df(2L)al:bk1) (Weinkove et al., 1997)
Recent Updates
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FB2012_01	References Marygold et al., 2011, Fly 5(4): 291--303
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Lewis, 1945)
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, de Belle et al., 1989, Lewis, 1945, Huettner and Bryant, 1988, Harbecke and Lengyel, 1995, Chandrashekaran, 1995, Dornan et al., 1997, Adler et al., 1998, Korochkina and Golubovsky, 1978)
Breakpoints	21B7--21B8;[] (Alcedo et al., 1996) 21B8-21C1;21C7-21C8 (Huettner and Bryant, 1988) 21B8-21C1;21C8-21D1 (Lewis, 1945, de Belle et al., 1989, Pauli et al., 1995, Harbecke and Lengyel, 1995, Chandrashekaran, 1995, Adler et al., 1998) 21C1;21C7 (Dornan et al., 1997) 21C1;21C8 (Korochkina and Golubovsky, 1978)
Causes alleles
Carries alleles	ds^al (Couso, 2000.2.10)
Transposon Insertions
Formalized genetic data	U2af38 << bk1 << fs(2)al << bk2 << lwr
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Schneitz et al., 1993)
Comments on Cytology
	The distal breakpoint of Df(2L)al is about 300kb from the telomere. (Brentrup et al., 2000) Pi3K21B probably overlaps the distal breakpoint. (Weinkove et al., 1997) Left breakpoint is just before 21C1-21C2, right breakpoint is just before 21D1-21D2. (Lewis, 1945) Left limit of break 1 from polytene analysis (FBrf0031322) Right limit of break 1 from inclusion of al (FBrf0006343) Left limit of break 2 from polytene analysis (FBrf0047732) Right limit of break 2 from polytene analysis (FBrf0098232)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	al (Franc et al., 1999, Korochkina and Golubovsky, 1978, Schneitz and Noll, 1990, Lewis, 1945) crq (Franc et al., 1999) ds (BDGP Project Members, 1994-1999) ebi (Spradling et al., 1999, BDGP Project Members, 1994-1999, Dong et al., 1999, Marygold et al., 2011) ex (Franc et al., 1999, Spradling et al., 1999, Korochkina and Golubovsky, 1978, Huettner and Bryant, 1988, Lewis, 1945, BDGP Project Members, 1994-1999, Tyler et al., 2007) fs(2)al (Chandrashekaran, 1995) mbm (Heisenberg et al., 1985, Albert et al., 1993, Albert et al., 1995) oro (Epps et al., 1997) RpI135 (Spradling et al., 1999, BDGP Project Members, 1994-1999) RpLP1 (Fauvarque et al., 2001, Lewis, 1945) ush (Franc et al., 1999, Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995, Goldman-Levi et al., 1996) α-Adaptin (BDGP Project Members, 1994-1999, Gonzalez-Gaitan and Jackle, 1997, Spradling et al., 1999, Berdnik et al., 2002)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cpb (Delalle et al., 2005) ds (Couso, 2000.2.10) for (de Belle et al., 1989) Gsc (Spradling et al., 1999, BDGP Project Members, 1994-1999) Hop (BDGP Project Members, 1994-1999) ifm(2)RU5 (Nongthomba and Ramachandra, 1999) kis (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)gl (Brumby et al., 2004, Korochkina and Golubovsky, 1978, Lewis, 1945) l(2)k06506 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k07005 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k07308 (BDGP Project Members, 1994-1999) l(2)k08915 (Spradling et al., 1999, BDGP Project Members, 1994-1999) lwr (Spradling et al., 1999, BDGP Project Members, 1994-1999) net (Korochkina and Golubovsky, 1978, Lewis, 1945) Nle (Royet et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999) numb (BDGP Project Members, 1994-1999) Pph13 (Zelhof et al., 2003) rempA (Lee et al., 2008) S (Lewis, 1945) smo (Alcedo et al., 1996, van den Heuvel and Ingham, 1996) spen (Eun et al., 2007) U2af38 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Stated to delete or disrupt ds. Aspects of this conclusion subsequently challenged, see FBrf0125086. (Lewis, 1945, Adler et al., 1998, Korochkina and Golubovsky, 1978, Spradling et al., 1999)
Phenotypic Data
In combination with other aberrations	Df(2L)al dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. (Fauvarque et al., 2001) No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989) Viable in combination with In(2LR)al^v. (Lewis, 1945) Df(2L)al/In(2LR)al⁸ heterozygotes survive poorly; escapers have reduced aristae, broad thoraces, arched wings, incomplete veins and large eyes (Koroshkina and Golubovsky, 1978).
NOT in combination with other aberrations	The Df(2L)al chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2L)al results in 2.6% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Wild-type clones made in the ovaries of a mutant female, are significantly larger than clones of heterozygous mutant cells. This size difference is greater in clones initiated at 48 hours after egg laying (AEL) than 2 hours AEL. (Extavour and Garcia-Bellido, 2001) Homozygous Df(2L)al mutants show an increase in cardial and pericardial cells during embryonic development. (Fossett et al., 2000) Df(2L)al in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D Dsim\Int(2L)D produces fertile male flies. These flies are female sterile. (Sawamura et al., 2000) Macrophages in homozygotes remain very small and round with a much lower phagocytic index (PI) for apoptotic corpses than wild type (0.26 compared to 3.96). Heterozygotes show a PI of about 1.5. (Franc et al., 1999) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Does not act as a dominant suppressor of N^nd-1. (Royet et al., 1998) Strong enhancer of B. (Epps et al., 1997) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Maternal hemizygosity for Df(2L)al significantly increases post-fertilization embryonic mortality. Paternal hemizygosity has no effect. (Chandrashekaran, 1995) Homozygous embryos do not complete head involution and tracheae are disconnected. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygous lethal. (Korochkina and Golubovsky, 1978) Heterozygotes have an extreme Minute phenotype with rough eyes. (Lewis, 1945) Homozygous lethal heterozygous Minute phenotype
Stocks ( 4 )
Bloomington	3548 Df(2L)al, ds^al/In(2L)Cy, Cy¹
Kyoto	107090 Df(2L)al, ds^al/In(2L)Cy, Cy¹ 101423 Df(2L)al, al^* / In(2L)Cy, E(S)¹ Cy¹ 101424 Df(2L)al / CyO, Cy¹ dp^lv1 pr¹ cn² P{ry^+t7.2=ftz/lacC}
Notes on Origin
Discoverer	E.B. Lewis, 1940.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df(2)al (Korochkina and Golubovsky, 1978, Golubovsky et al., 1978, Hirose et al., 2001) Df(2L)a1 (Harris et al., 2003) Df(2L)al (Tyler et al., 2007, Crest et al., 2007, Eun et al., 2007, Raabe et al., 2004, Zelhof et al., 2003, Lee et al., 2008, Marygold et al., 2011) Dfal (Couso and Bishop, 1998) M(2)21C (Fauvarque et al., 2001)
Name Synonym	Deficiency (2L) aristaless
Secondary FlyBase IDs

References ( 74 )

Generate a list of	All references relating to this aberration ( 74 )

List References by type	Research paper ( 63 ) Supplementary material ( 1 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) Abstract ( 4 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Marygold et al., 2011, Fly 5(4): 291--303 Genetic characterization of ebi reveals its critical role in Drosophila wing growth. [FBrf0216882] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...

Aberration Dmel\Df(2L)al

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