Aberration Dmel\Df(2L)ast4

General Information
Symbol	Dmel\Df(2L)ast4	Species	D. melanogaster
Name	Deficiency (2L) asteroid	FlyBase ID	FBab0001697
Feature type	chromosomal_deletion

Computed Breakpoints include	21D1-21D2;21E2
Deleted segment	21D1--21E2
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Roberts et al., 1985)
Class of aberration (relative to progenitor)	chromosomal_deletion (Roberts et al., 1985)
Breakpoints	21D1-21D2;21E1-21E2 (Roberts et al., 1985)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(2)21Dg << l(2)21Dd << bk2
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0042627) Left limit of break 2 from inclusion of ast (FBrf0042627) Right limit of break 2 from polytene analysis (FBrf0042627)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ast (Roberts et al., 1985) GluRIIC (Marrus et al., 2004) ninaA (Schneuwly et al., 1989)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(2L)ast4 heterozygotes have a missing-bract phenotype (17% of bracts in the tibia and 78% in the basitarsus of the second leg remain). (Held, 2002)
Stocks ( 2 )
Bloomington	6115 Df(2L)ast4/SM1
Kyoto	108615 Df(2L)ast4/SM1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)ast4 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl and deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248). (Mason et al., 2004)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	df(2L)ast4 (Marrus et al., 2004) Df(2L)ast-4 (Roberts et al., 1985, Schneuwly et al., 1989) Df(2L)ast4 Df(2R)ast4 (Artero et al., 2003)
Name Synonym	Deficiency (2L) asteroid
Secondary FlyBase IDs

References ( 9 )
Research paper	Marrus et al., 2004, J. Neurosci. 24(6): 1406--1415 Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. [FBrf0174850] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Artero et al., 2003, Development 130(25): 6257--6272 Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. [FBrf0167513] Held, 2002, Mech. Dev. 117(1-2): 225--234 Bristles induce bracts via the EGFR pathway on Drosophila legs. [FBrf0152194] Chan et al., 2001, Molec. Biol. Cell 12(5): 1409--1419 Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. [FBrf0137029] Schneuwly et al., 1989, Proc. Natl. Acad. Sci. USA 86: 5390--5394 Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). [FBrf0050847] Roberts et al., 1985, Genetics 109: 145--156 A genetic and cytogenetic analysis of the region surrounding the LSP-1 gene of Drosophila melanogaster. [FBrf0042627]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]